Results 121 to 130 of about 154,598 (309)
Modulation of apoptosis against P. falciparum by low dose radiation in human PBMCs
Journal of Infection in Developing Countries, 2009 Background: Implications of low dose radiation (LDR) have been well reported in cancer therapy but data is scanty on the therapeutic application of LDR in infectious diseases. Methodology: Human peripheral blood mononuclear cells (PBMCs) were cultured
Sompal Singh +2 more
doaj +1 more source
IL-6 production is higher in PBLs than in PBMCs.
, 2014 PBMCs and PBLs were prepared as described in the Materials and Methods, stimulated for 1, 3 or 6-12 (4 ng/mL), IL-15 (10 ng/mL), IL-18 (40 ng/mL), TL1A (100 ng/mL) and TL1AAb (1 µg/mL) and IL-6 was measured in the supernatants.
Kirsten Reichwald (507044) +3 more
core +1 more source
Advanced Science, EarlyView.SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu +8 more
wiley +1 more source
Correlation of FKBP51 with autophagy pathway components in human PBMCs.
, 2014 Protein levels of FKBP51 and Beclin1 (A), pAktS473/Akt (B), LC3B-II/I (C), and Atg12 (D) in PBMCs from healthy men (n = 21). Each dot represents the levels of FKBP51 and the respective protein in the PBMCs from one individual.
Jens Stepan (395842) +19 more
core +1 more source
AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint
Advanced Science, EarlyView.AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz +4 more
wiley +1 more source
Alexandria Journal of Medicine, 2014 Background: Hepatitis C virus (HCV) has been found to infect peripheral blood mononuclear cells (PBMCs), using them as a reservoir, which might contribute to the development of resistance to treatment.
Abdel Fatah Fahmy Hanno +3 more
doaj +1 more source
CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors
Advanced Science, EarlyView.Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen +12 more
wiley +1 more source
, 2017 Fluorescent exosomes (A) were incubated with PBMCs for 5 hours and the uptake by CD14+ monocytes, CD4+ or CD8+ T cells was measured by flow cytometric analysis in the bulk population.
Miran Skrap (659303) +10 more
core +1 more source
Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor
Advanced Science, EarlyView.The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao +11 more
wiley +1 more source
, 2013 PBMCs were isolated by density gradient from the blood of controls (n = 10), VL patients (n = 14) and treated VL patients (n = 12) and the activity of arginase was measured by enzymatic assay.
Ellen Closs (396015) +15 more
core +1 more source