Results 41 to 50 of about 29,162 (220)
Developmental Cell, 2004 Pbx and Meis proteins act as cofactors to various transcription factors, but their exact functions have been unclear. A report by Berkes et al. in Molecular Cell now demonstrates that Pbx and Meis may penetrate repressive chromatin to mark specific genes for activation.
openaire +2 more sources
Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends
Med Research, EarlyView.The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley +1 more source
4 open, 2019 The attempt to restore homeostasis, once disrupted, such that complex signaling, crosstalk between ubiquitous proteins, and a diverse range of pathways gone awry is near impossible, especially in the presence of an ongoing pathogenic stimuli with ...
Brücher Björn L.D.M., Jamall Ijaz S.
doaj +1 more source
Online Learning of Noisy Data with Kernels [PDF]
, 2010 We study online learning when individual instances are corrupted by adversarially chosen random noise. We assume the noise distribution is unknown, and may change over time with no restriction other than having zero mean and bounded variance.
Cesa-Bianchi, Nicolò +2 more
core +4 more sources
Propellants, Explosives, Pyrotechnics, EarlyView.ABSTRACT Mechanical properties are a critical performance metric for many high explosive (HE) materials and tensile strength properties are particularly important. Direct tensile measurements using dogbone shaped samples are the gold standard but they have the disadvantage that they are fairly large and require samples machined from billets.
Paul B. Mirkarimi
wiley +1 more source
Asian Journal of Andrology, 2020 Intraductal carcinoma of the prostate (IDC-P) is an aggressive pathological pattern of prostate cancer (PCa). We investigated the association of IDC-P in prostate biopsy (PBx) with several pathological features after radical prostatectomy (RP) and its ...
Sha Zhu +9 more
doaj +1 more source
Ultrasound Characterization of Plastic Bonded Explosives With Varied Binder Content and Density
Propellants, Explosives, Pyrotechnics, EarlyView.ABSTRACT Advanced explosive formulations and methods of production require rapid characterization for both processes and materials. Here, we present results for ultrasound characterization of a plastic bonded explosive (PBX) formulation as a function of binder weight percent and pressing density using through‐transmission sound speed measurements.
Jordan S. Lum +6 more
wiley +1 more source
Consistent nonparametric Bayesian inference for discretely observed scalar diffusions [PDF]
, 2013 We study Bayes procedures for the problem of nonparametric drift estimation for one-dimensional, ergodic diffusion models from discrete-time, low-frequency data. We give conditions for posterior consistency and verify these conditions for concrete priors,
van der Meulen, Frank, van Zanten, Harry
core +3 more sources
Propellants, Explosives, Pyrotechnics, EarlyView.This study presents an alternative method to manufacture polymer‐bonded explosives by partially curing an HTPB‐based molding powder prior to compaction. The study shows that the length of partial cure time before compaction directly influenced the geometric fidelity, homogeneity, compressive strength, density, and internal microstructure.
Ismar L. Chew +4 more
wiley +1 more source
BJU International, EarlyView.Objective To refine prostate cancer (PCa) pathways by comparing micro‐ultrasonography‐targeted biopsy (micro‐US‐TBx) with magnetic resonance imaging (MRI)‐TBx for detecting clinically significant PCa (csPCa) and by evaluating diagnostic accuracy (sensitivity, specificity, positive predictive value, negative predictive value).
José Pedro Cassemiro Micheleto +12 more
wiley +1 more source