Results 231 to 240 of about 601,144 (294)

Abstract Representation of Movement Parameters in Basal Ganglia Output

Advanced Science, EarlyView.
The basal ganglia output provides a scalable velocity/position signal across behavioral contexts, supporting the idea that these variables are represented in the brain as abstract entities rather than as fixed changes in joint angles or specific sets of body effectors.
Ana Silvia Báez‐Cordero, Diana I. Ortega‐Romero, Claudia I. Pérez‐Díaz, Pavel E. Rueda‐Orozco   +3 more
wiley   +1 more source

Hierarchical Flux‐Protection Engineering Stabilizes Oxidation‐Prone Metabolic Nodes for High‐Level Curcumin Biosynthesis

Advanced Science, EarlyView.
Flux‐protection engineering stabilizes an oxidation‐prone L‐DOPA node in engineered E. coli by combining acid‐adapted chassis evolution, respiratory‐chain modulation, enzyme‐level flux matching, and pH–DO control. Carbon is redirected from oxidative browning to productive biosynthesis, enabling 1075.2 mg/L curcumin and demonstrating transferability to ...
Jianbin Chen, Qihang Chen, Shurong Zhang, Yajuan Su, Xiaoyi Zou, Ke Wang, Shike Liu, Qian He, Liang Zhang, Weizhu Zeng, Jingwen Zhou   +10 more
wiley   +1 more source

Lipoprotein(a) and Prostate Cancer: A Systematic Review of Observational, Genetic and Mendelian Randomization Evidence. [PDF]

Int J Mol Sci
Kisiała M, Bajurny W, Karwacki J, Marcinkowska A, Litarski M, Tulski M, Zawadzki D, Patrzałek P, Gurwin A, Nowak Ł, Krajewski W, Szydełko T, Małkiewicz B.   +12 more
europepmc   +1 more source

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Advanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu   +12 more
wiley   +1 more source

Development and internal validation of a clinical model to increase the diagnostic probability of prostate cancer in patients with prostate-specific antigen levels of 4.0-10.0 ng/mL. [PDF]

Transl Androl Urol
Xu B, Jiang J, Zhang L, Ge Q, Liu J, Zhou J.   +5 more
europepmc   +1 more source

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source

The role of the p53 signaling pathway in prostate cancer. [PDF]

Transl Androl Urol
Shi R, Fu H, Wang X, Ye C, Ji X, Zhao H, Zhang Y, Fan D.   +7 more
europepmc   +1 more source

Impact of thrombectomy techniques on outcome in medium or distal vessel occlusion: subanalysis of the DISTAL Trial. [PDF]

J Neurointerv Surg
Schulze-Zachau V, Rommers N, Dobrocky T, Hajdu SD, Fiehler J, Fragata I, Gralla J, Machi P, Kirschke JS, van Es ACGM, Kaesmacher J, Buhk JH, Saver JL, Martínez-Galdámez M, Piechowiak EII, Kaiser DPO, Tancredi I, Van Den Bergh F, Hellstern V, Khanafer A, Volders D, Strbian D, Ribo M, Karwacki GM, Aebischer V, Brehm A, Fischer U, Psychogios MN, Collaborators D.   +28 more
europepmc   +1 more source