Results 61 to 70 of about 573,989 (290)

martaajarzyna/PCA-ForAnalysisOfBiodiversityChange: First release of PCA for biodiversity assessments (Jarzyna and Stagge)

, 2022
This is the code for using Principal Component Analysis (PCA) for assessments of change in multiple facets of biodiversity (manuscript in review by Jarzyna and Stagge)
Marta Jarzyna
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Dimensionality Reduction and Classification of Dermatological Images using PCA and Machine Learning [PDF]

EPJ Web of Conferences
Skin diseases pose grave diagnosis issues since they are highly similar among classes and have varied patterns over the various skin colors, particularly in Indian subjects. The current work proposes a mixed strategy using transfer learning-based feature
Surwadkar Tushar, Deshmukh Sujata
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Le fait du prince comme cause d’admission au régime de force majeure en droit minier congolais : notion, portée et implications [PDF]

Mouvements et Enjeux Sociaux
La succession d’évènements tragiques au cours des XX et XXIe siècles a mis en évidence l’importance de la gestion des risques avec notamment des risques industriels, financiers, sociétaux (les soulèvements), sanitaires (pandémie de covid-19), ou encore ...
Patrick BONDONGA LESAMBO , Kevin ESHIMATA NGIMBI   +1 more
doaj  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Efficient PCA-Exploration of High-Dimensional Datasets [PDF]

, 2020
Basic tools for exploration and interpretation of Principal Component Analysis (PCA) results are well- known and thoroughly described in many comprehensive tutorials. However, in the recent decade, several new tools have been developed. Some of them were
Oxana Ye., Rodionova, Alexey L., Pomerantsev, Sergey, Kucheryavskiy   +2 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Specificities and sensitivities (defined as TN / (TN + FP) and FN / (FN + TP), respectively) by changing thresholds of 2D-PCA MSM and B-2D-PCA-R MSM.

, 2021
Specificities and sensitivities (defined as TN / (TN + FP) and FN / (FN + TP), respectively) by changing thresholds of 2D-PCA MSM and B-2D-PCA-R MSM.
Yumi Iwashita (11261748), Ryo Kurazume (9529108), Adrian Stoica (9297896), Hitoshi Sakano (11261751)   +3 more
core   +1 more source