Results 51 to 60 of about 389,587 (260)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Novel use of waste sawdust in green stormwater infrastructure (GSI)
Results in EngineeringAs urban populations grow, finding appropriate strategies for managing waste and stormwater is becoming increasingly more challenging. While the incorporation of waste materials into concrete has been studied for structural components, the use of waste ...
Ebru Özer, Berrin Tansel
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Electronic Journal of Plant BreedingAn Elite Spring Wheat Yield Trial (EWYT) was conducted with 50 diverse genotypes of Wheat (Triticum aestivum L.) and analyzed by multivariate analysis during 2018-19 rabi season. Correlation analysis revealed positive association of plant height, grains
Ponaganti Shiva Kishore1, Suvendu Kumar Roy1*, Saikat Das2, S. Vishnupriya1, Basid Ali1, Lakshmi Hijam1, Moumita Chakraborty1, Puspendu Dutta3, Rupsanatan Mandal4 and Sanghamitra Rout5
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Assessment of variation in rice maintainer lines using principal component analysis
Electronic Journal of Plant BreedingThe aim of this study was to explore the characteristics essential for a maintainer line to effectively complement the A lines in hybrid rice production.
B. Edukondalu1, V. Ram Reddy1, T. Shobha Rani1, CH. Aruna Kumari2 and B. Soundharya3
doaj +1 more source
Journal of Food and Pharmaceutical Sciences, 2019 Herein, this work aimed to develop and assess feasibility of multivariate model of partial least square analysis for specific quantification of pitavastatin (PVT)-loaded self-nano emulsion (SNE) formulation using UV Vis spectrophotometry. PVT loaded into
Kuncahyo I +4 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Czech Journal of Animal Science, 2020 The study estimated phenotypic correlations between reproductive traits in sows classified as maternal (Polish Large White, Polish Landrace, and Yorkshire) and paternal (Duroc, Berkshire, and Hampshire) components, kept on farms located in Poland and in ...
Błażej Nowak +3 more
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source