Results 161 to 170 of about 601,144 (294)

G Protein-Coupled Receptors in Prostate Cancer: Pathophysiological Implications and Potential for Innovative Therapeutics. [PDF]

Int J Mol Sci
Sarmento-Cabral A, Herrero-Aguayo V, Sáez-Martínez P, Alors-Pérez E, León-González AJ, López-Cánovas JL, Montero-Hidalgo AJ, Gahete MD, Jiménez-Vacas JM, Luque RM.   +9 more
europepmc   +1 more source

Deciphering Anti‐Cancer Drug Efficacy Through Nanomechanical Vibrations in Living Gastric Cancer Organoids

Advanced Science, EarlyView.
This study developed an efficacy assessment platform that integrates patient‐derived gastric cancer organoids, atomic force microscopy (AFM)‐based nanomechanical vibration detection, deep learning analysis, and organoid mechanical modeling. It detects picomolar drug effects within 0.1 s signal, achieves 97% classification accuracy, and offers non ...
Ting Zhang, Qiubo Chen, Shihai Lan, Liang Zhu, Shuaiyu Liu, Yan Xia, Yalu Zhang, Hanhui Yao, Yongman Liu, Shangquan Wu, Qingchuan Zhang   +10 more
wiley   +1 more source

<i>N</i>6-methyladenosine-dependent ARv7 translation couples lactate metabolism with enzalutamide resistance in prostate cancer. [PDF]

Sci Adv
Zhang M, Cheng B, Jia M, Li X, Huang Y, Li B, Wang X, Shao J, Deng Q, Yu W, Li M, Yang Z, Liang C, Li T, Dai R, Wang R.   +15 more
europepmc   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Racial Variations in PSA and PSA Density Among Men With Negative Prostate Biopsies: A Multicenter Comparative Study of Chinese, African American, and Caucasian American Populations. [PDF]

Cancer Med
Xiong Z, Zhou P, Xu A, Guo C, Xiong S, Tang P.   +5 more
europepmc   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Monitoring based on MIC-PCA and SVDD for industrial process

, 2017
Complex industrial processes are often non-linear and non-Gaussian, while the traditional principal component analysis (PCA) method assumes that the data are Gaussian and linear.
Wang ZW(王中伟), Zhou XF(周晓锋), Li S(李帅), Song H(宋宏)   +3 more
core  

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Prostate tissue microbiota dysbiosis associated with prostate cancer: results from the MICROPROSTK multicenter study. [PDF]

New Microbes New Infect
Lotte R, Gaudart A, Cruzel C, Droupy S, Lavigne JP, Bruyère F, Lanotte P, Lechevallier E, Dubourg G, Fournier PE, Haider R, Lotte L, Youssef K, Emery A, Madany R, Payen M, Pfauwadel L, Tibi B, Ahallal Y, Zouari S, Bentellis I, Fontas E, Durand M, Ruimy R.   +23 more
europepmc   +1 more source

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source