Results 11 to 20 of about 2,658 (198)

FUT8 Is a Critical Driver of Prostate Tumour Growth and Can Be Targeted Using Fucosylation Inhibitors. [PDF]

Cancer Med
ABSTRACT Background An unmet clinical need requires the discovery of new treatments for men facing advanced prostate cancer. Aberrant glycosylation is a universal feature of cancer cells and plays a key role in tumour growth, immune evasion and metastasis.
Bastian K, Orozco-Moreno M, Thomas H, Hodgson K, Visser EA, Rossing E, Pijnenborg JFA, Eerden N, Wilson L, Saravannan H, Hanley O, Grimsley G, Frame F, Peng Z, Knight B, McCullagh P, McGrath J, Crundwell M, Harries L, Maitland NJ, Heer R, Wang N, Goddard-Borger ED, Guerrero RH, Boltje TJ, Drake RR, Scott E, Elliott DJ, Munkley J.   +28 more
europepmc   +2 more sources

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models. [PDF]

Mol Oncol
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Classon J, Stenudd M, Zamboni M, Alkass K, Eriksson CJ, Pedersen L, Schörling A, Thoss A, Bergh A, Wikström P, Adami HO, Sørensen HT, Druid H, Frisén J.   +13 more
europepmc   +2 more sources

ST6GAL1‐mediated aberrant sialylation promotes prostate cancer progression

The Journal of Pathology, Volume 261, Issue 1, Page 71-84, September 2023., 2023
Abstract Aberrant glycosylation is a universal feature of cancer cells, and cancer‐associated glycans have been detected in virtually every cancer type. A common change in tumour cell glycosylation is an increase in α2,6 sialylation of N‐glycans, a modification driven by the sialyltransferase ST6GAL1.
Emma Scott, Emily Archer Goode, Rebecca Garnham, Kirsty Hodgson, Margarita Orozco‐Moreno, Helen Turner, Karen Livermore, Kyla Putri Nangkana, Fiona M Frame, Abel Bermudez, Fernando Jose Garcia Marques, Urszula L McClurg, Laura Wilson, Huw Thomas, Adriana Buskin, Anastasia Hepburn, Adam Duxfield, Kayla Bastian, Hayley Pye, Hector M Arredondo, Gerald Hysenaj, Susan Heavey, Urszula Stopka‐Farooqui, Aiman Haider, Alex Freeman, Saurabh Singh, Edward W Johnston, Shonit Punwani, Bridget Knight, Paul McCullagh, John McGrath, Malcolm Crundwell, Lorna Harries, Rakesh Heer, Norman J Maitland, Hayley Whitaker, Sharon Pitteri, Dean A Troyer, Ning Wang, David J Elliott, Richard R Drake, Jennifer Munkley   +41 more
wiley   +1 more source

Turning SKD 11 Hardened Steel: An Experimental Study of Surface Roughness and Material Removal Rate Using Taguchi Method

Advances in Materials Science and Engineering, Volume 2023, Issue 1, 2023., 2023
Heat‐treated steel is widely used in industrial applications due to its high strength and other desirable mechanical qualities. Grinding, which requires a lot of power and is expensive, is typically used to harden machining. In recent times, hard machining has emerged as a viable alternative to grind in select applications.
Shah Ashiquzzaman Nipu, Rezaul Karim, Aquib Rahman, Mahjabin Moon, I. A. Choudhury, Junayed Bin Omar, Marsia Sultana Khushbu, Tomasz Trzepieciński   +7 more
wiley   +1 more source

Intermittent machining of hardened steels with different types of PcBN cutting tools [PDF]

FME Transactions, 2023
The paper discusses the results of the experimental investigation of the performance of several grades of PcBN cutting composites in conditions of the interrupted machining of hardened steel.
Sergiyovych Manokhin Andriy, Anatoliyovych Klymenko Sergii, Oleksiyovich Melniychuk Yuriy, Anatoliyovych Klymenko Sergii, Olegovich Pasichnyi Oleg, Li Xin, Kamchatnaya-Stepanova Kateryna Valeriivna, Sergiyovich Osipov Oleksandr   +7 more
doaj   +1 more source

Proceedings of the Sustainable Concrete Materials and Structures in Construction 2020 [PDF]

, 2020
Seminar on Sustainable Concrete Materials and Structures in Concrete Construction 2020 was held virtually for the first time on 24 August 2020. This event was organized by the Faculty of Civil Engineering and Built Environment (FKAAB), Universiti Tun ...
Mohd Zuki, Sharifah Salwa, Mokhatar, Shahrul Niza, Shahidan, Shahiron, Wan Ibrahim, Mohd Haziman   +3 more
core   +1 more source

Effect of ZrB2 Particles on Machining Parameters of AA7475 Alloy‐Based Composites by Optimization Technique

Advances in Materials Science and Engineering, Volume 2023, Issue 1, 2023., 2023
ZrB2 particle‐reinforced AA7475 is a potential material for high‐performance aeronautical engine blades because of its exceptional characteristics. The machinability of ZrB2/AA7475 metal matrix composites (MMC) is still a challenge because of the influence of ZrB2 particles.
C. R. Mahesha, R. Suprabha, R. Suresh Kumar, Chirumamill Mallika Chowdary, Viyat Varun Upadhyay, M. Soumya, Essam A. Al-Ammar, Sivasankar Palaniappan, Abdi Diriba, Pudhupalayam Muthukutti Gopal   +9 more
wiley   +1 more source

The effect of hydrogen on the fracture toughness of friction‐stir welded API 5L X70 pipeline steels

Fatigue &Fracture of Engineering Materials &Structures, Volume 45, Issue 10, Page 3009-3024, October 2022., 2022
Abstract The hydrogen embrittlement (HE) leads to severe steel degradation of mechanical properties. The hydrogen atoms diffuse into the steel and get positioned into reversible and irreversible trap sites. The pipe to transport oil and gas needs to be welded to construct long‐distance pipeline projects; thus, friction‐stir welding (FSW) has proven an ...
Joseane M. Giarola, Julian A. Avila, Osvaldo M. Cintho, Haroldo C. Pinto, Marcelo F. de Oliveira, Waldek W. Bose Filho   +5 more
wiley   +1 more source

The prostate tissue‐based telomere biomarker as a prognostic tool for metastasis and death from prostate cancer after prostatectomy

The Journal of Pathology: Clinical Research, Volume 8, Issue 5, Page 481-491, September 2022., 2022
Abstract Current biomarkers are inadequate prognostic predictors in localized prostate cancer making treatment decision‐making challenging. Previously, we observed that the combination of more variable telomere length among prostate cancer cells and shorter telomere length in prostate cancer‐associated stromal cells – the telomere biomarker – is ...
Christopher M Heaphy, Corinne E Joshu, John R Barber, Christine Davis, Jiayun Lu, Reza Zarinshenas, Edward Giovannucci, Lorelei A Mucci, Meir J Stampfer, Misop Han, Angelo M De Marzo, Tamara L Lotan, Elizabeth A Platz, Alan K Meeker   +13 more
wiley   +1 more source

A Contemporary Review on Friction Stir Welding of Circular Pipe Joints and the Influence of Fixtures on This Process

Advances in Materials Science and Engineering, Volume 2022, Issue 1, 2022., 2022
The permanent metal joining processes play a vital role in assembling the complex aluminium structures of the aerospace, automotive, marine, and oil industries. The invention of friction stir welding (FSW) redefined the mechanism of metal joining to produce high‐quality welds by eliminating the consumption of electrodes and shielding gases, resulting ...
S. M. Senthil, M. Bhuvanesh Kumar, Milon Selvam Dennison, Fuat Kara   +3 more
wiley   +1 more source