Results 51 to 60 of about 75,408 (291)

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

Comportamiento de la oclusión dentaria en pacientes operados de cirugía ortognática

Revista Médica Electrónica
Introducción: la cirugía ortognática corrige las alteraciones del componente esquelético en las anomalías dentomaxilofaciales. Estas deformidades provocan deficiente relación de los huesos maxilares, afectando la oclusión dentaria y sus funciones ...
Félix Manuel Blanco Mederos, Kenia Blanco Ramos, Mario Arturo Pichardo Valiente, Doris Soto Caballero, Evelio Garcia Pulido, Rene Rodríguez Sarduy   +5 more
doaj  

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

DNA Nanoflower LYTACs Enable Efficient VEGF Degradation and Verteporfin Loading for Combined Therapy of Wet Age‐Related Macular Degeneration

Advanced Science, EarlyView.
An integrated approach that combines a DNA nanoflower VEGF degrader with photodynamic therapy is developed for the treatment of wet age‐related macular degeneration, which reduces the risk of VEGF reactivation‐induced CNV recurrence and minimizes the systemic side effects associated with photodynamic therapy.
Mengxuan Li, Yan Yue, Sijin Wu, Xinyu He, Jiayi Song, Shuwen Ma, Haokun Zhang, Chenyu Xu, Song Chen, Yanming Huang, Songbo Xie, Hua Yan   +11 more
wiley   +1 more source

A metáfora no discurso do trasgressor

Forma y Función, 2010
A metáfora se materializa nos discursos através de múltiplas regras específicas de aparecimento. Este trabalho tem como objetivo verificar quais são os mecanismos, através dos quais, a metáfora funciona no discurso transgressor.
Barbosa de Souza Jefferson, Lescano Guerra Vânia Maria   +1 more
doaj   +2 more sources

Comportamiento de pacientes tratados con sobredentaduras implantomucosoportadas en la consulta de Implantología Bucal de la Clínica Estomatológica Docente III Congreso del PCC. Matanzas

Revista Médica Electrónica
Una de las modalidades terapéuticas de la prótesis bucal es la sobredentadura implantomucosoportada, la cual rehabilita al edente total con la posibilidad de una unión directa de la prótesis a los implantes osteointegrados.
Félix M Blanco Mederos, Eddy Abreu Pérez   +1 more
doaj  

Disulfide‐Bridged Ru Complex–Mediated Photo‐Disulfidptosis for Colorectal Cancer Therapy

Advanced Science, EarlyView.
In this work, a binuclear ruthenium complex, RuSSRu was developed for efficient colorectal cancer (CRC) treatment. The synergistic interaction between disulfidptosis and lysosomal damage‐induced apoptosis induced by RuSSRu amplified tumor cell death. This innovative approach offers a potent therapeutic strategy for CRC.
Simeng He, Wendong Jin, Jiaojiao Pang, Xiaoting Gong, Shixian Cao, Duo Mao, Yuguo Chen, Kang‐Nan Wang, Bin Liu   +8 more
wiley   +1 more source

Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits

Advanced Science, EarlyView.
A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao, Hanpeng Luo, Dailu Guan, Xuefeng Fu, Feng Wang, Guoming Zhang, Shanglai Li, Hua Yang, Yanli Zhang   +8 more
wiley   +1 more source

Láser helio-neón combinado con clorhexidina al 0,2 %.: Efectos clínicos y microbiológicos en el tratamiento de la gingivitis crónica

Revista Cubana de Estomatología
La gingivitis crónica constituye una de las formas más frecuentes de enfermedad periodontal, caracterizada por la inflamación crónica de la encías, tumefacción, enrojecimiento y sangramiento.
Tatiana Peña Ruiz, Ariel Delgado Ramos, Ariadna González Lorenzo   +2 more
doaj  

Generating Dynamic Structures Through Physics‐Based Sampling of Predicted Inter‐Residue Geometries

Advanced Science, EarlyView.
While static structure prediction has been revolutionized, modeling protein dynamics remains elusive. trRosettaX2‐Dynamics is presented to address this challenge. This framework leverages a Transformer‐based network to predict inter‐residue geometric constraints, guiding conformation generation via physics‐based iterative sampling. The resulting method
Chenxiao Xiang, Wenkai Wang, Zhenling Peng, Jianyi Yang   +3 more
wiley   +1 more source