Results 91 to 100 of about 35,703 (223)
Arteriosclerosis, Thrombosis, and Vascular Biology, 2004 Many of the most important breakthroughs in science do not come from hypothesis-driven experiments. Apart from serendipity, genetics is perhaps our best route to discoveries that elude our intuition. Genetics establishes a relationship between a gene and a phenotype, but does not necessarily provide mechanistic information. The emerging story of PCSK9 (
openaire +2 more sources
PCSK9 monoclonal antibodies: An overview
Heart Views, 2020 PCSK9 monoclonal antibodies are novel lipid-lowering therapy that have been extensively studied in patients with hypercholesterolemia either as monotherapy or as an add-on to other LLTs. PCSK9 monoclonal antibodies have significantly reduced the low-density lipoprotein cholesterol (LDL-C) plasma level resulting in a better LDL-C goal attainment.
Rasha Kaddoura +2 more
openaire +3 more sources
C/EBPα is Essential for Gonadal but Not Inguinal White Adipose Tissue Formation in Mice
Obesity, EarlyView.Human genetics has linked the gene CEBPA to waist to hip ratio and adipose distribution. We generated mice with AdipoQ‐Cre driven deletion of Cebpa and found these mice to have a specific reduction in gonadal white adipose tissue and myriad other metabolic phenotypes.
Krista Y. Hu +10 more
wiley +1 more source
Thrombosis Journal, 2021 Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is considered to have multiple roles in the development of atherosclerosis, which is recently reported to participate in the thrombotic process. We aimed to examine the relationship between
Jia Peng +9 more
doaj +1 more source
Outcome-based pricing for new pharmaceuticals via rebates [PDF]
, 2020 The price of new brand-name prescription drugs has been rising fast in the United States. For example, the Amgen cholesterol drug Repatha had an initial list price of $14,523 per year.
Adida, E
core
Molecular analysis and intestinal expression of SAR1 genes and proteins in Anderson's disease (Chylomicron retention disease). [PDF]
, 2011 International audienceBACKGROUND: Anderson's disease (AD) or chylomicron retention disease (CMRD) is a very rare hereditary lipid malabsorption syndrome.
Georges, Amandine +13 more
core +3 more sources
Precision Medical Sciences, EarlyView.This graphical summary highlights the clinical application of single‐nucleotide polymorphisms‐based risk stratification in coronary artery disease. By integrating polygenic risk with clinical assessment, imaging, and preventive strategies, genetic information enables earlier risk identification, optimized screening, and personalized lifestyle and ...
Li Dai +8 more
wiley +1 more source
International Journal of the Cardiovascular AcademyHypercholesterolemia, a major contributor to atherosclerotic cardiovascular disease, remains inadequately controlled despite widespread statin use, particularly in patients with familial hypercholesterolemia or statin intolerance.
Agung Cendekia Putra Nusantara +4 more
doaj +1 more source
Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
wiley +1 more source