Results 101 to 110 of about 35,703 (223)

Plasma PCSK9 levels are significantly modified by statins and fibrates in humans

Lipids in Health and Disease, 2008
Background Proprotein convertase subtilisin kexin-like 9 (PCSK9) is a secreted glycoprotein that is transcriptionally regulated by cholesterol status. It modulates levels of circulating low density lipoprotein cholesterol (LDLC) by negatively regulating ...
Mbikay Majambu, LaHaye Stephen A, Lahey Karen A, Chaplin Anna, Cousins Marion, Raymond Angela, Dewpura Thilina, Mayne Janice, Ooi Teik, Chrétien Michel   +9 more
doaj   +1 more source

Shared genetic contribution of type 2 diabetes and cardiovascular disease: Implications for prognosis and treatment [PDF]

, 2018
Purpose of Review: The increased cardiovascular disease (CVD) risk in subjects with type 2 diabetes (T2D) is well established. This review collates the available evidence and assesses the shared genetic background between T2D and CVD: the causal ...
Strawbridge, Rona J., van Zuydam, Natalie R.   +1 more
core   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

The associations between proprotein convertase subtilisin/kexin type 9 E670G polymorphism and the risk of coronary artery disease and serum lipid levels: a meta-analysis [PDF]

, 2015
BACKGROUND: Studies had investigated the associations between proprotein convertase subtilisin/kexin type 9 (PCSK9) E670G polymorphism and coronary artery disease (CAD) and lipid levels, but the results were controversial.
Bifeng Zhang, Chunyan Ma, Ganwei Shi, Gaojun Cai, Ji Zhang, Weijin Weng, Yanbin Song   +6 more
core   +2 more sources

Impact of specialised endocrinology care on metabolic control and healthcare utilisation outcomes after kidney transplantation in patients with diabetes: A 12‐month observational cohort study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims To evaluate whether an endocrinology‐integrated transplant clinic and differing healthcare delivery models are associated with metabolic outcomes during the first year after kidney transplantation in recipients with pre‐existing diabetes.
Joaquin Lado‐Abeal, Francisco Gude, Maria Jose Ginzo‐Villamayor, Khalid Al‐Zubaidi, Jacqueline C. Stocking, Gemma Rodriguez‐Carnero, Aili Guo, Prasanth Surampudi, Caroline Lenaerts, Vedesh K. Babu, Deborah Plante, Yihung Huang, Antia Fernandez‐Pombo   +12 more
wiley   +1 more source

Neuronal PCSK9 regulates cognitive performances via the modulation of ApoER2 synaptic localization

Pharmacological Research
PCSK9 promotes the degradation of the low-density lipoprotein receptors and its inhibition by monoclonal antibodies or gene silencing approaches results in the reduction of plasma cholesterol levels coupled to that of cardiovascular events.
Silvia Pelucchi, Lorenzo Da Dalt, Giulia De Cesare, Ramona Stringhi, Laura D’Andrea, Filippo La Greca, Clara Cambria, Lina Vandermeulen, Elisa Zianni, Stefano Musardo, Silvia Roda, Fabrizia Bonacina, Sofia Nasini, Maria Giovanna Lupo, Nicola Ferri, Stefano Comai, Fabrizio Gardoni, Flavia Antonucci, Diego Scheggia, Monica Di Luca, Giuseppe Danilo Norata, Elena Marcello   +21 more
doaj   +1 more source

Traditsioonilised ja uued ravimid aterogeense düslipideemia ravis [PDF]

, 2016
Kardiovaskulaarse riski kahandamise põhialuseks on LDL-kolesterooli sisalduse vähendamine. Statiinid on näidanud hulgalistes juhuslikustatud kliinilistes uuringutes tõhusust ja ohutust ning on muutunud sellega aterogeense düslipideemia valikravimiks ...
Viigimaa, Margus
core   +2 more sources

High levels of serum cholesterol increase the risk of developing vessel co‐opting tumors in colorectal cancer liver metastases

The FEBS Journal, EarlyView.
High serum cholesterol is linked to colorectal cancer liver metastases (CRCLM) subtypes with poor survival (replacement pattern). Levels of cholesterol under 4 mmol·L−1 correlated with better survival and a desmoplastic pattern subtype. Furthermore, in vivo PCSK9 inhibitor evolocumab, which lowers cholesterol, reduced liver metastases.
Amatzia Gantz, Audrey Kapelanski‐Lamoureux, Miran Rada, Lucyna Krzywon, Migmar Tsamchoe, Anastasia Tsatoumas, Stephanie K. Petrillo, Nabil G. Seidah, Anthoula Lazaris, Peter Metrakos   +9 more
wiley   +1 more source

Proprotein convertase subtilisin/kexin type 9 deficiency in extrahepatic tissues: emerging considerations

Frontiers in Pharmacology
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is primarily secreted by hepatocytes. PCSK9 is critical in liver low-density lipoprotein receptors (LDLRs) metabolism.
Fengyuan Lu, En Li, Xiaoyu Yang, Xiaoyu Yang   +3 more
doaj   +1 more source

Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 (ANXA2) gene. [PDF]

, 2017
BACKGROUND AND AIMS: Annexin-A2 (AnxA2) is an endogenous inhibitor of proprotein convertase subtilisin/kexin type-9 (PCSK9). The repeat-one (R1) domain of AnxA2 binds to PCSK9, blocking its ability to promote degradation of low-density lipoprotein ...
Anastasia Z. Kalea, Anders Franco-Cereceda, Andrew Wong, Aroon Hingorani, Barbara J. Jefferis, Bernstein, Bharadwaj, Boardman-Pretty, Bresnick, Bulger, Cariou, Cartharius, Claudia Giambartolomei, Decker, Diana Kuh, Fairoozy, Gerke, Global Lipids Genetics C, Grewal, Grewal, Hedhli, J.P. Casas, Jackie Cooper, Jackie F. Price, Jon White, Kim, Ko, Kotowski, Kwon, Lang, Lasse Folkersen, Liu, Ly, Mayer, McDowell, Meena Kumari, Mika Kivimaki, Nassoury, Nikolaev, Peter Whincup, Pierce, Poirier, Rebecca Hardy, Reva, Roaa Hani Fairoozy, S. Goya Wannamethee, Seidah, Seidah, Spano, Stela McLachlan, Steve E. Humphries, Thomas Grewal, Tom R. Gaunt, Turley, Ward, Ward, Westra, Yoav Ben-Shlomo, Yusufzai, Zweig   +59 more
core   +5 more sources