Results 101 to 110 of about 40,685 (224)

Conditional knockdown of hepatic PCSK9 ameliorates high-fat diet-induced liver inflammation in mice

Frontiers in Pharmacology
InstructionAccumulating evidence has shown that proprotein convertase subtilisin/kexin type 9 (PCSK9) is associated with inflammation in the vascular system. However, the roles of PCSK9 in hepatic inflammation remain unclear.
Xue-Ying Zhang, Qing-Qing Lu, Yan-Jie Li, Shan-Rui Shi, Chao-Nan Ma, Miao Miao, Shou-Dong Guo   +6 more
doaj   +1 more source

Traditsioonilised ja uued ravimid aterogeense düslipideemia ravis [PDF]

, 2016
Kardiovaskulaarse riski kahandamise põhialuseks on LDL-kolesterooli sisalduse vähendamine. Statiinid on näidanud hulgalistes juhuslikustatud kliinilistes uuringutes tõhusust ja ohutust ning on muutunud sellega aterogeense düslipideemia valikravimiks ...
Viigimaa, Margus
core   +2 more sources

Hepatic GCGR is required for the superior weight loss and metabolic effects of a structurally related analogue of the dual GCGR/GLP‐1R agonist survodutide in mice

Diabetes, Obesity and Metabolism, EarlyView.
Fen Long, Tenagne D. Challa, Vissarion Efthymiou, Manuel Klug, Thomas Klein, Heike Neubauer, Christian Wolfrum, Carla Horvath   +7 more
wiley   +1 more source

Ligase‐Catalyzed Transcription and Reverse Transcription of XNA by T3 DNA Ligase

Current Protocols, Volume 6, Issue 1, January 2026.
Abstract The growing utility of xeno‐nucleic acids (XNAs) lies in their ability to extend the reach of genetic chemistry beyond the limits imposed by natural polymers. XNAs, with their diverse chemical backbones, resist enzymatic degradation and yet retain the capacity for sequence‐defined information, and have found broad applications in biotechnology.
Natalie Khamissi, Luca Rustico, Ryan Hili   +2 more
wiley   +1 more source

Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway [PDF]

, 2019
Sea spray aerosols (SSAs) have profound effects on our climate and ecosystems. They also contain microbiota and biogenic molecules which could affect human health. Yet the exposure and effects of SSAs on human health remain poorly studied.
Asselman, Jana, De Rijcke, Maarten, De Schamphelaere, Karel, Janssen, Colin, Mees, Jan, Tilleman, Laurentijn, Van Acker, Emmanuel, Van Nieuwerburgh, Filip   +7 more
core   +3 more sources

Lipoprotein(a) and PCSK9 inhibition: clinical evidence [PDF]

, 2020
Massimiliano Ruscica, Maria Francesca Greco, Nicola Ferri, Alberto Corsini   +3 more
openalex   +1 more source

Long non‐coding RNA lncAPAT promotes atherosclerotic plaque instability by targeting ribosomal protein L22

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
LncAPAT interacted with the promoter region of RPL22 to inhibit RPL22 transcriptional activity and increase the expression of MCP‐1, thereby contributing to plaque instability. Abstract Background Long non‐coding RNAs (lncRNAs) regulate macrophage inflammation and atherosclerotic plaque stability, but mechanisms need comprehensive investigations ...
Rongxia Li, Qiyue Zhang, Yu Chen, Shuting Wang, Shuang Han, Adalaiti Kamili, Yixuan Zhong, Shujun Yang, Weili Zhang   +8 more
wiley   +1 more source

Characterization of the role of EGF-A of low density lipoprotein receptor in PCSK9 binding

Journal of Lipid Research, 2013
Proprotein convertase subtilisin kexin-like 9 (PCSK9) promotes the degradation of low density lipoprotein receptor (LDLR) and plays an important role in regulating plasma LDL-cholesterol levels.
Hong-mei Gu, Ayinuer Adijiang, Matthew Mah, Da-wei Zhang   +3 more
doaj   +1 more source

Beyond lipids: Systemic effects of lipoprotein apheresis

Transfusion, EarlyView.
Menatalla Nadim, Yamac Akgun
wiley   +1 more source

Astragalus membranaceus—Salvia miltiorrhiza Decoction Ameliorates Metabolic Syndrome and Gut Microbiota Dysbiosis Induced by High‐Fat Diet: A Comparative Study

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
The optimal pairing ratio of ASDs against hyperlipidemia was systematically investigated. ASD maintains intestinal homeostasis and improves the systemic inflammatory response. A new LC–MS/MS method for the determination of derivatized SCFAs was established. ASD regulates the gut microbiota and its metabolites (SCFAs and BAs).
Haiyin Zhang, Haofang Wan, Yihang Lu, Yu He, Haitong Wan, Chang Li   +5 more
wiley   +1 more source