Results 21 to 30 of about 40,773 (330)

PCSK9 Inhibitors in Cancer Patients Treated with Immune-Checkpoint Inhibitors to Reduce Cardiovascular Events: New Frontiers in Cardioncology

Cancers, 2023
Simple Summary Atherosclerosis is a critical cardiovascular disease associated with the use of immune checkpoint inhibitors (ICIs). Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key orchestrator of atherosclerotic process and it is also ...
V. Quagliariello, I. Bisceglia, M. Berretta, M. Iovine, M. Canale, C. Maurea, Vienna Giordano, A. Paccone, A. Inno, N. Maurea   +9 more
semanticscholar   +1 more source

PCSK9 function and physiology [PDF]

Journal of Lipid Research, 2008
PCSK9 has exploded onto center stage plasma cholesterol metabolism, raising hopes for a new strategy to treat hypercholesterolemia. PCSK9 in a plasma protein that triggers increased degradation of the LDL receptor. Gain-of-function mutations in PCSK9 reduce LDL receptor levels in the liver, resulting in high levels of LDL cholesterol in the plasma and ...
Andrew S. Peterson, Loren G. Fong, Stephen G. Young   +2 more
openaire   +4 more sources

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in the treatment of dyslipidemia

Медицинский совет, 2021
Dyslipidemia makes a substantial contribution to the mortality as one of the leading pathogenetic factors for cardiovascular diseases. The nature and degree of the effect on the blood lipid spectrum may vary in the lipid-lowering drugs from different ...
A. A. Shikaleva, M. L. Maximov, N. M. Kiseleva   +2 more
doaj   +1 more source

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

Nature Biotechnology, 2021
Most known pathogenic point mutations in humans are C•G to T•A substitutions, which can be directly repaired by adenine base editors (ABEs). In this study, we investigated the efficacy and safety of ABEs in the livers of mice and cynomolgus macaques for ...
Tanja Rothgangl, Melissa K Dennis, Paulo J. C. Lin, Rurika Oka, D. Witzigmann, L. Villiger, W. Qi, M. Hrůzová, Lucas Kissling, Daniela Lenggenhager, Costanza Borrelli, S. Egli, Nina Frey, Noëlle Bakker, John A. Walker, A. Kadina, D. Victorov, Martin Pacesa, Susanne Kreutzer, Zacharias Kontarakis, A. Moor, M. Jinek, D. Weissman, M. Stoffel, R. van Boxtel, K. Holden, N. Pardi, B. Thöny, J. Häberle, Ying K. Tam, S. Semple, Gerald Schwank   +31 more
semanticscholar   +1 more source

PCSK9 attenuates efferocytosis in endothelial cells and promotes vascular aging

Theranostics, 2023
Aims: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that binds to low-density lipoprotein receptors. Efferocytosis is the process by which phagocytes remove apoptotic cells.
Shijie Liu, Jinzi Wu, Amanda Stolarz, Huiliang Zhang, Marjan Boerma, Stephanie D. Byrum, Nancy J Rusch, Zufeng Ding   +7 more
semanticscholar   +1 more source

Cholesterol metabolism is altered in Rett syndrome: A study on plasma and primary cultured fibroblasts derived from patients [PDF]

, 2014
Rett (RTT) syndrome is a severe neurological disorder that affects almost exclusively females. Several detectable mutations in the X-linked methyl-CpG-binding protein 2 gene (MECP2) are responsible for the onset of the disease.
Di Tunno, Ilenia, Hayek, Joussef, Pallottini, Valentina, Segatto, Marco, Sticozzi, Claudia, Trapani, Laura, Valacchi, Giuseppe   +6 more
core   +13 more sources

PCSK9 facilitates melanoma pathogenesis via a network regulating tumor immunity

Journal of experimental & clinical cancer research : CR, 2023
Background PCSK9 regulates cholesterol homeostasis and promotes tumorigenesis. However, the relevance of these two actions and the mechanisms underlying PCSK9’s oncogenic roles in melanoma and other cancers remain unclear.
Yan Gu, Xiaozeng Lin, Ying Dong, G. Wood, N. Seidah, G. Werstuck, Pierre Major, M. Bonert, Anil Kapoor, D. Tang   +9 more
semanticscholar   +1 more source

Polymorphic Variant rs11206510 in PCSK9 and Risk of Coronary Artery Disease in Bulgarians

Acta Medica Bulgarica, 2023
The aim of this study was to investigate the potential association of rs11206510 in PCSK9 gene with coronary artery disease (CAD) and myocardial infarction (MI) in Bulgarians.
Tzveova R., Yaneva-Sirakova T., Naydenova G., Vandeva S., Pendicheva-Duhlenska D., Atanasov P., Mitev V., Kaneva R.   +7 more
doaj   +1 more source

A cVLP-Based Vaccine Displaying Full-Length PCSK9 Elicits a Higher Reduction in Plasma PCSK9 Than Similar Peptide-Based cVLP Vaccines

Vaccines, 2022
Administration of PCSK9-specific monoclonal antibodies, as well as peptide-based PCSK9 vaccines, can lower plasma LDL cholesterol by blocking PCSK9. However, these treatments also cause an increase in plasma PCSK9 levels, presumably due to the formation ...
Louise Goksøyr, Magdalena Skrzypczak, Maureen Sampson, Morten A. Nielsen, Ali Salanti, Thor G. Theander, Alan T. Remaley, Willem A. De Jongh, Adam F. Sander   +8 more
doaj   +1 more source

Efficacy and Safety of an Investigational Single-Course CRISPR Base-Editing Therapy Targeting PCSK9 in Nonhuman Primate and Mouse Models

Circulation, 2022
Background: VERVE-101 is an investigational in vivo CRISPR base-editing medicine designed to alter a single DNA base in the PCSK9 gene, permanently turn off hepatic protein production, and thereby durably lower low-density lipoprotein cholesterol.
Richard G. Lee, A. Mazzola, Maurine C. Braun, Colin Platt, Scott B Vafai, S. Kathiresan, E. Rohde, Andrew M Bellinger, A. Khera   +8 more
semanticscholar   +1 more source