Results 41 to 50 of about 40,685 (224)

PCSK9 deficiency alters brain lipid composition without affecting brain development and function

Frontiers in Molecular Neuroscience, 2023
PCSK9 induces lysosomal degradation of the low-density lipoprotein (LDL) receptor (LDLR) in the liver, hereby preventing removal of LDL cholesterol from the circulation.
Angela Pärn, Ditte Olsen, Jürgen Tuvikene, Jürgen Tuvikene, Mathias Kaas, Ekaterina Borisova, Ekaterina Borisova, Mesut Bilgin, Mie Elhauge, Joachim Vilstrup, Joachim Vilstrup, Peder Madsen, Peder Madsen, Mateusz C. Ambrozkiewicz, Roman U. Goz, Tõnis Timmusk, Tõnis Timmusk, Victor Tarabykin, Victor Tarabykin, Camilla Gustafsen, Camilla Gustafsen, Simon Glerup, Simon Glerup   +22 more
doaj   +1 more source

PCSK9: A Key Target for the Treatment of Cardiovascular Disease (CVD) [PDF]

Advanced Pharmaceutical Bulletin, 2020
Proprotein convertase subtilisin/kexin type 9 (PCSK9), as a vital modulator of low-density lipoprotein cholesterol (LDL-C) , is raised in hepatocytes and released into plasma where it binds to LDL receptors (LDLR), leading to their cleavage.
Saeideh Sobati, Amir Shakouri, Mahdi Edalati, Daryoush Mohammadnejad, Reza Parvan, Javad Masoumi, Jalal Abdolalizadeh   +6 more
doaj   +1 more source

Antioxidant Activity and Potential Cholesterol Modulating Effect of Punica granatum L. Peel Hydroethanolic Extract. [PDF]

Chem Biodivers
Punica granatum peel extract is rich in phenolic compounds, exhibits strong antioxidant activity, and modulates the expression of PCSK9 and LDL receptors. Collectively, these findings suggest a potential cardioprotective effect of the extract. ABSTRACT Lipoprotein metabolism is regulated by several key proteins, notably proprotein convertase subtilisin/
Chaaba R, Nakbi A, Rossi I, Jrah H, Amri Z, Ferri N, Hammami S, Dall'Acqua S, Hammami M, Mehri S.   +9 more
europepmc   +2 more sources

Association of Serum Anti-PCSK9 Antibody Levels with Favorable Postoperative Prognosis in Esophageal Cancer

Frontiers in Oncology, 2021
BackgroundEsophageal cancer often appears as postoperative metastasis or recurrence after radical surgery. Although we had previously reported that serum programmed cell death ligand 1 (PD-L1) level correlated with the prognosis of esophageal cancer ...
Masaaki Ito, Takaki Hiwasa, Takaki Hiwasa, Yoko Oshima, Satoshi Yajima, Takashi Suzuki, Tatsuki Nanami, Makoto Sumazaki, Fumiaki Shiratori, Kimihiko Funahashi, Shu-Yang Li, Yasuo Iwadate, Hiroki Yamagata, Byambasteren Jambaljav, Minoru Takemoto, Minoru Takemoto, Koutaro Yokote, Hirotaka Takizawa, Hideaki Shimada, Hideaki Shimada   +19 more
doaj   +1 more source

Epigenetic Regulation of ITGB7 Promotes Coronary Heart Disease via Immune and Metabolic Pathways: A Multimodal Mendelian Randomization Study. [PDF]

Cardiovasc Ther
Background Coronary heart disease (CHD) is a leading cause of cardiovascular mortality worldwide, with its pathogenesis being complex and not yet fully understood. The rapid development of genomics, especially in epigenetic research, has provided essential tools for identifying new pathogenic targets. This study is aimed at systematically exploring the
Guo J, Huang F, Lu P, Lu M.
europepmc   +2 more sources

Effect of alirocumab on lipids and lipoproteins in individuals with metabolic syndrome without diabetes: Pooled data from 10 phase 3 trials. [PDF]

, 2018
AimsThis analysis assessed the efficacy and safety of alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, in patients with or without metabolic syndrome (MetS) using pooled data from 10 phase 3 ODYSSEY trials.Materials and methodsData ...
Bujas-Bobanovic, Maja, Ginsberg, Henry N, Henry, Robert R, Letierce, Alexia, Louie, Michael J, Müller-Wieland, Dirk, Taub, Pam R   +6 more
core   +1 more source

Association of high proprotein convertase subtilisin/kexin type 9 antibody level with poor prognosis in patients with diabetes: a prospective study

Scientific Reports, 2023
In addition to pathogenic autoantibodies, polyclonal autoantibodies with unknown physiological roles and pathogenicity are produced in the body. Moreover, serum antibodies against the proprotein convertase subtilisin/kexin type 9 (PCSK9) protein, which ...
Hiroki Yamagata, Aiko Hayashi, Yoich Yoshida, Masaya Koshizaka, Shunichiro Onishi, Tomohiko Yoshida, Takaki Hiwasa, Minoru Takemoto   +7 more
doaj   +1 more source

Cholesterol metabolism is altered in Rett syndrome: A study on plasma and primary cultured fibroblasts derived from patients [PDF]

, 2014
Rett (RTT) syndrome is a severe neurological disorder that affects almost exclusively females. Several detectable mutations in the X-linked methyl-CpG-binding protein 2 gene (MECP2) are responsible for the onset of the disease.
Di Tunno, Ilenia, Hayek, Joussef, Pallottini, Valentina, Segatto, Marco, Sticozzi, Claudia, Trapani, Laura, Valacchi, Giuseppe   +6 more
core   +3 more sources

Circulating Levels of Proprotein Convertase Subtilisin/Kexin Type 9 and Arterial Stiffness in a Large Population Sample: Data From the Brisighella Heart Study [PDF]

, 2017
Proprotein convertase subtilisin/kexin type 9 (PCSK9) circulating levels are significantly associated with an increased risk of cardiovascular events.
Borghi, Claudio, Botta, Margherita, Cicero, Arrigo F. G., D'Addato, Sergio, Ferri, Nicola, Fogacci, Federica, Giovannini, Marina, Magni, Paolo, Marchiano, Silvia, Rosticci, Martina, Ruscica, Massimiliano   +10 more
core   +2 more sources

Roles of reconstituted high-density lipoprotein nanoparticles in cardiovascular disease: A new paradigm for drug discovery [PDF]

, 2020
Epidemiological results revealed that there is an inverse correlation between high-density lipoprotein (HDL) cholesterol levels and risks of atherosclerotic cardiovascular disease (ASCVD).
Huang, Hui, Huang, Jiansheng, Huang, Li-Hao, Wang, Dongdong   +3 more
core   +2 more sources