Results 51 to 60 of about 40,773 (330)

The Mystery of PCSK9 [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2004
Many of the most important breakthroughs in science do not come from hypothesis-driven experiments. Apart from serendipity, genetics is perhaps our best route to discoveries that elude our intuition. Genetics establishes a relationship between a gene and a phenotype, but does not necessarily provide mechanistic information. The emerging story of PCSK9 (
openaire   +3 more sources

Effect of a novel nutraceutical combination on serum lipoprotein functional profile and circulating PCSK9 [PDF]

, 2017
BACKGROUND: A beneficial effect on cardiovascular risk may be obtained by improving lipid-related serum lipoprotein functions such as high-density lipoproteins (HDLs) cholesterol efflux capacity (CEC) and serum cholesterol loading capacity (CLC) and by ...
Adorni, Maria Pia, Bernini, Franco, Ferri, Nicola, Izzo, Raffaele, Marchiano, Silvia, Rozza, Francesco, Trimarco, Valentina, Zimetti, Francesca   +7 more
core   +3 more sources

Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance

Nature Communications, 2022
Evidence suggests that caffeine (CF) reduces cardiovascular disease (CVD) risk. However, the mechanism by which this occurs has not yet been uncovered.
P. Lebeau, J. Byun, Khrystyna Platko, P. Saliba, Matthew Sguazzin, Melissa E. MacDonald, G. Paré, G. Steinberg, L. Janssen, Suleiman A. Igdoura, M. Tarnopolsky, S. R. Wayne Chen, N. Seidah, Jakob Magolan, R. Austin   +14 more
semanticscholar   +1 more source

PCSK9 is not secreted from mature differentiated intestinal cells

Journal of Lipid Research, 2021
Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes lysosomal degradation of the LDL receptor and is a key regulator of cholesterol metabolism. After the liver, the small intestine is the second organ that highly expresses PCSK9.
Moreau François, Aurélie Thédrez, Damien Garçon, Audrey Ayer, Thibaud Sotin, Wieneke Dijk, Claire Blanchard, Gilliane Chadeuf, Lucie Arnaud, Mikael Croyal, Laurianne Van Landeghem, Melissa Touvron, Xavier Prieur, Anna Roubtsova, Nabil Seidah, Annik Prat, Bertrand Cariou, Cedric Le May   +17 more
doaj  

Increased serum PCSK9 levels are associated with renal function impairment in patients with type 2 diabetes mellitus

Renal Failure, 2023
Purpose The purpose of this study was to investigate the association between serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels and renal function impairment in type 2 diabetes mellitus (T2DM) patients.Methods PCSK9 levels were measured ...
Zhicai Feng, Xiangyu Liao, Hao Zhang, Juan Peng, Zhijun Huang, Bin Yi   +5 more
doaj   +1 more source

A Comprehensive Review of PCSK9 Inhibitors

Journal of Cardiovascular Pharmacology and Therapeutics, 2022
Cardiovascular disease (CVD) is the leading cause of death in the United States and worldwide. A major risk factor for this condition is increased serum low-density lipoprotein cholesterol (LDL-C) levels for which statins have been successful in reducing
Caroline Coppinger, M. Movahed, Veronica Azemawah, Lee Peyton, J. Gregory, Mehrnoosh Hashemzadeh   +5 more
semanticscholar   +1 more source

Naturally Occurring PCSK9 Inhibitors [PDF]

Nutrients, 2020
Genetic, epidemiological and pharmacological data have led to the conclusion that antagonizing or inhibiting Proprotein convertase subtilisin/kexin type 9 (PCSK9) reduces cardiovascular events. This clinical outcome is mainly related to the pivotal role of PCSK9 in controlling low-density lipoprotein (LDL) cholesterol levels.
Maria Pia Adorni, Francesca Zimetti, Maria Giovanna Lupo, Massimiliano Ruscica, Nicola Ferri   +4 more
openaire   +6 more sources

PCSK9 deficiency alters brain lipid composition without affecting brain development and function

Frontiers in Molecular Neuroscience, 2023
PCSK9 induces lysosomal degradation of the low-density lipoprotein (LDL) receptor (LDLR) in the liver, hereby preventing removal of LDL cholesterol from the circulation.
Angela Pärn, Ditte Olsen, Jürgen Tuvikene, Jürgen Tuvikene, Mathias Kaas, Ekaterina Borisova, Ekaterina Borisova, Mesut Bilgin, Mie Elhauge, Joachim Vilstrup, Joachim Vilstrup, Peder Madsen, Peder Madsen, Mateusz C. Ambrozkiewicz, Roman U. Goz, Tõnis Timmusk, Tõnis Timmusk, Victor Tarabykin, Victor Tarabykin, Camilla Gustafsen, Camilla Gustafsen, Simon Glerup, Simon Glerup   +22 more
doaj   +1 more source

Circulating Levels of Proprotein Convertase Subtilisin/Kexin Type 9 and Arterial Stiffness in a Large Population Sample: Data From the Brisighella Heart Study [PDF]

, 2017
Proprotein convertase subtilisin/kexin type 9 (PCSK9) circulating levels are significantly associated with an increased risk of cardiovascular events.
Borghi, Claudio, Botta, Margherita, Cicero, Arrigo F. G., D'Addato, Sergio, Ferri, Nicola, Fogacci, Federica, Giovannini, Marina, Magni, Paolo, Marchiano, Silvia, Rosticci, Martina, Ruscica, Massimiliano   +10 more
core   +2 more sources

Gene Expression and Methylation Levels of PCSK9 Gene in Iraqi Patients with Coronary Artery Disease [PDF]

, 2023
يرتبط التعبير الجيني لجين  PCSK9ارتباطًا وثيقًا بمستويات الدهون وخطر الإصابة بمرض تصلب الشرايين التاجية. تهدف الدراسة الحالية إلى قياس كمية التعبير الجيني للجين PCSK9 وتأثير المثيلة على مستوى تعبيره الذي يساهم في التسبب في اضطراب الشريان التاجي الحاد ...
Abdulfattah, Shaimaa Y., Al-Attar, Marwa M., Al-Awadi, Salwa J. Al-Awadi   +2 more
core   +2 more sources