Results 61 to 70 of about 40,773 (330)

PCSK9 Inhibition: From Current Advances to Evolving Future

Cells, 2022
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secretory serine protease synthesized primarily by the liver. It mainly promotes the degradation of low-density lipoprotein receptor (LDL-R) by binding LDL-R, reducing low-density lipoprotein ...
Chunping Liu, Jing Chen, Huiqi Chen, Tong Zhang, Dongyue He, Qiyuan Luo, Jiaxin Chi, Z. Hong, Yi-Jen Liao, Shihui Zhang, Qizhe Wu, Huan Cen, Guang-li Chen, Jinxin Li, Lei Wang   +14 more
semanticscholar   +1 more source

Markers of neutrophil mediated inflammation associate with disturbed continuous electroencephalogram after out of hospital cardiac arrest

Acta Anaesthesiologica Scandinavica, Volume 67, Issue 1, Page 94-103, January 2023., 2023
Abstract Background Achieving an acceptable neurological outcome in cardiac arrest survivors remains challenging. Ischemia‐reperfusion injury induces inflammation, which may cause secondary neurological damage. We studied the association of ICU admission levels of inflammatory biomarkers with disturbed 48‐hour continuous electroencephalogram (cEEG ...
Pirkka T. Pekkarinen, Federico Carbone, Silvia Minetti, Davide Ramoni, Giuseppe Ristagno, Roberto Latini, Lauri Wihersaari, Kaj Blennow, Henrik Zetterberg, Jussi Toppila, Pekka Jakkula, Matti Reinikainen, Fabrizio Montecucco, Markus B. Skrifvars   +13 more
wiley   +1 more source

Assessing the functional consequence of loss of function variants using electronic medical record & Large-Scale Genomics Consortium Efforts

Frontiers in Genetics, 2014
Estimates from large scale genome sequencing studies indicate that each human carries up to 20 genetic variants that are predicted to results in loss of function (LOF) of protein-coding genes.
Patrick eSleiman, Jonathan eBradfiled, Frank eMentch, Berta eAlmoguera, John eConnolly, Hakon eHakonarson   +5 more
doaj   +1 more source

Elevated circulating PCSK9 level is associated with 28-day mortality in patients with sepsis: a prospective cohort study

BMC Emergency Medicine, 2023
Objectives Pro-protein convertase subtilisin/kexin 9 (PCSK9) decreases the clearance of the pathogenic lipids, supporting the potential role of PCSK9 in the prognosis of sepsis.
Yuanlu Shu, Ziwei Deng, Ye Deng, Jianliang Zhou, Jin Wang, Zhenxing Duan, Tao Jiang, Xiang Zhao, Zhihua Shi, Chengfeng Qiu   +9 more
doaj   +1 more source

Effect of the proprotein convertase subtilisin/kexin type 9 inhibitor evolocumab on glycemia, body weight, and new-onset diabetes mellitus [PDF]

, 2017
Statin therapy modestly increases new-onset diabetes risk. The effect of proprotein convertase subtilisin/kexin type 9 inhibition on new-onset diabetes, glycemia, and weight remains unclear.
Blom, Dirk J., Cyrille, Marcoli, Elliott, Mary, Koren, Michael J., Preiss, David, Sattar, Naveed, Somaratne, Ransi, Soran, Handrean, Toth, Peter P., Uhart, Magdalena   +9 more
core   +1 more source

PCSK9 inhibition potentiates cancer immune checkpoint therapy

Nature, 2020
Despite its success in achieving the long-term survival of 10–30% of treated individuals, immune therapy is still ineffective for most patients with cancer1,2.
Xinjian Liu, Xuhui Bao, Mengjie Hu, Hanman Chang, Meng Jiao, Jin Cheng, Liyi Xie, Qian Huang, Fang Li, Chuan-Yuan Li   +9 more
semanticscholar   +1 more source

Expanding Biology of PCSK9: Roles in Atherosclerosis and Beyond

Current Atherosclerosis Reports, 2022
Since the discovery of PCSK9 in 2003, this proprotein convertase was shown to target specific receptors for degradation in endosomes/lysosomes, including LDLR and other family members and hence to enhance the levels of circulating LDL-cholesterol (LDLc).
N. Seidah, D. Garçon
semanticscholar   +1 more source

New approaches in detection and treatment of familial hypercholesterolemia [PDF]

, 2015
Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder that clinically leads to increased low density lipoprotein-cholesterol (LDL-C) levels. As a consequence, FH patients are at high risk for cardiovascular disease (CVD). Mutations
Hartgers, ML, Hovingh, GK, Ray, KK
core   +6 more sources

SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion. [PDF]

, 2013
The secretory pathway of eukaryotic cells packages cargo proteins into COPII-coated vesicles for transport from the endoplasmic reticulum (ER) to the Golgi.
Adams, Elizabeth, Bai, Yongsheng, Baines, Andrea, Bajaj, Kanika, Chen, Xiao-Wei, Ginsburg, David, Lin, Jiandie, Liu, Hui-Hui, Ma, Danjun, Meng, Zhuo-Xian, Sartor, Maureen A, Schekman, Randy, Wang, He, Yi, Zhengping, Young, Stephen G, Yu, Genggeng, Zhang, Bin, Zhang, Pengcheng   +17 more
core   +1 more source

PCSK9 Biology and Its Role in Atherothrombosis

International Journal of Molecular Sciences, 2021
It is now about 20 years since the first case of a gain-of-function mutation involving the as-yet-unknown actor in cholesterol homeostasis, proprotein convertase subtilisin/kexin type 9 (PCSK9), was described.
C. Barale, E. Melchionda, A. Morotti, I. Russo   +3 more
semanticscholar   +1 more source