Results 41 to 50 of about 642,659 (199)

Acute Effect of Evolocumab on Lipoprotein(a) Level and Inflammation in Patients with Coronary Artery Disease

Journal of Cardiovascular Development and Disease, 2022
Background: Several studies have shown that high plasma lipoprotein(a) concentrations are associated with an increased risk of arteriosclerotic cardiovascular disease. Thus, Lp(a) has emerged as a new therapeutic target. Circulating proprotein convertase
Seung Woo Choi, Joan Kim, Gyeong Won Jang, Young Shin Lee, Jin Sun Park, Jung Myung Lee, Hyung Oh Kim, Hyemoon Chung, Jong Shin Woo, Woo Shik Kim, Weon Kim   +10 more
doaj   +1 more source

Bioactive cyclization optimizes the affinity of a proprotein convertase subtilisin/kexin type 9 (PCSK9) peptide inhibitor

, 2021
Peptides are regarded as promising next-generation therapeutics. However, an analysis of over 1000 bioactive peptide candidates suggests that many have underdeveloped affinities and could benefit from cyclization using a bridging linker sequence.
Lammi C., Gilding E. K., Tombling B. J., Craik D. J., Wang C. K., Grazioso G., Lawrence N.   +6 more
core   +1 more source

Control of dyslipidemia in the prevention of recurrent ischemic cerebrovascular accidents (expert opinion)

Неврология, нейропсихиатрия, психосоматика, 2022
On July 6, 2022, an interdisciplinary meeting of the Expert Council was held on the topic "Control of dyslipidemia in the prevention of acute and recurrent ischemic cerebrovascular accidents".
M. M. Tanashyan, N. A. Shamalov, I. A. Voznyuk, S. N. Yanishevsky, O. I. Vinogradov, D. R. Khasanova, O. V. Tikhomirova, V. A. Parfenov, E. V. Oshchepkova, M. V. Ezhov, V. S. Gurevich, V. V. Arkhipov   +11 more
doaj   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Case Report: Neurological adverse events in subject with myasthenia gravis after PCSK9 inhibitor administration [PDF]

Frontiers in Cardiovascular Medicine
Jaroslav Hubacek, Vera Adamkova
exaly   +2 more sources

Role of PCSK9 on vascular calcification: study of an uremic mouse model

, 2022
reservedLa patologia cardiovascolare è la prima causa di morbilità e mortalità nei pazienti affetti da malattia renale cronica (CKD). Una funzione renale compromessa comporta un’alterazione del profilo lipidico e in associazione con elevati livelli ...
RIZZATO, MARTINA
core  

Beyond Simple Mimicry: Next‐Generation Geometric Architectures and Future Paradigms in Small‐Molecule and Macrocyclic Peptidomimetics

Angewandte Chemie, EarlyView.
Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee, Sumin Son, Jeong Yeon Yoo, Ji Hyae Lee, Meehyun Chun, Seung Bum Park   +5 more
wiley   +2 more sources

Circulating Rather Than Intestinal PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Regulates Postprandial Lipemia in Mice

, 2020
International audienceObjective: Increased postprandial lipemia (PPL) is an independent risk factor for atherosclerotic cardiovascular diseases. PCSK9 (Proprotein convertase subtilisin kexin type 9) is an endogenous inhibitor of the LDLR (low-density ...
Nabil Seidah, Lucie Arnaud, Ayer, Audrey, Prieur, Xavier, Arnaud, Lucie, Bertrand Cariou, Garçon, Damien, Prat, Annik, Annik Prat, Dijk, Wieneke, Cédric Le May, Anna Roubtsova, Damien Garçon, François Moreau, Seidah, Nabil, Cariou, Bertrand, Audrey Ayer, Moreau, François, Roubtsova, Anna, Wieneke Dijk, Xavier Prieur, Le May, Cedric   +21 more
core   +1 more source

L-methionine promotes CD8+ T cells killing hepatocellular carcinoma by inhibiting NR1I2/PCSK9 signaling

Neoplasia: An International Journal for Oncology Research
Background: Liver cancer has consistently high incidence and mortality rates among malignant tumors. PCSK9, a target for hypercholesterolemia therapy, has recently been identified as an inhibitor of anti-tumor immunity, and targeting PCSK9 effectively ...
Chengsha Yuan, Changpeng Hu, Huyue Zhou, Wuyi Liu, Wenjing Lai, Yafeng Liu, Yue Yin, Guobing Li, Rong Zhang   +8 more
doaj   +1 more source

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source