Results 1 to 10 of about 14,518 (216)
Anti-HMGCR Specificity of HALIP: A Confirmatory Study [PDF]
Journal of Immunology Research, 2020 A distinctive new indirect immunofluorescence pattern in liver tissue has been associated with anti-HMGCR autoantibodies. It is known as HALIP (HMGCR Associated Liver Immunofluorescence Pattern).
Andrés Baucells +6 more
doaj +8 more sources
HMGCR: a malignancy hub - frontiers in cancer diagnosis and therapy [PDF]
Frontiers in OncologyCholesterol metabolism is significantly activated during most tumor growth. As a key rate-limiting enzyme in cholesterol synthesis, HMG-CoA reductase (HMGCR) affects tumor metabolic reprogramming by upregulating cholesterol metabolism and promotes tumor ...
Yisong Yang +7 more
doaj +4 more sources
Viruses, 2019 Porcine circovirus type 2 (PCV2) is the etiological agent of porcine circovirus diseases and porcine circovirus-associated diseases (PCVDs/PCVADs). However, the pathogenesis of PCV2 is not fully understood.
Hongsheng Ouyang +2 more
exaly +4 more sources
Biomedicines, 2022 Introduction: immune-mediated necrotising myopathy (IMNM) is associated with pathogenic anti-signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) antibodies, at least partly through activation of the classical pathway of ...
Marion Carrette +2 more
exaly +4 more sources
Acta Pharmaceutica Sinica B, 2021 HMG-CoA reductase (HMGCR) protein is usually upregulated after statin (HMGCR inhibitor) treatment, which inevitably diminishes its therapeutic efficacy, provoking the need for higher doses associated with adverse effects.
Guoshun Luo, Xin Lin, Lizhe Zhu
exaly +3 more sources
Emerging roles of the metabolic regulator 3-hydroxy-3-methylglutaryl coenzyme-CoA reductase in human cancers: From biology to therapeutics [PDF]
Genes and DiseasesTumor cells alter several critical metabolic pathways to satisfy their demands for rapid proliferation and survival. Maladjustment of cholesterol metabolism is present in diverse types of tumor cells.
Wenfang Li +5 more
doaj +2 more sources
BRCC36 Deubiquitinates HMGCR to Regulate the Interplay Between Ferroptosis and Pyroptosis
Advanced ScienceAbstractVarious forms of programmed cell death (PCD) exhibit distinct characteristics depending on their specific molecular mechanisms, and there are interactions among these different forms. Ferroptosis, which is related to autophagy and apoptosis, has an unknown potential interaction with pyroptosis.
Long Shu, Yao Long, Yongguang Tao
exaly +4 more sources
The simultaneous targeted Inhibition of ISG15 and HMGCR disrupts cancer stemness through metabolic collapse and induces synthetic lethality in pancreatic ductal adenocarcinoma [PDF]
Journal of Experimental & Clinical Cancer ResearchPrecision oncology, a transformative paradigm in cancer therapeutics, leverages molecular profiling to design personalized interventions. Building on our prior discovery of ISG15’s role in pancreatic cancer stem cell (CSC) generation, we identified co ...
Jia Sun +8 more
doaj +2 more sources
On the Hypolipidemic Activity of Elicited Soybeans: Evidences Based on Computational Analysis
Indonesian Journal of Chemistry, 2022 Dietary intervention plays a significant role in regulating hyperlipidemia. Besides, elicited soybean has greater bioactive contents with numerous health benefits potential. However, there is no evidence of the hypolipidemic activity of elicited soybean.
Feri Eko Hermanto +3 more
doaj +1 more source
Frontiers in Ecology and Evolution, 2022 Comprising a major clade of Anura, toads produce and secrete numerous toxins from both the parotoid glands behind their eyes and their dorsal skin. These toxins, made of various proteins and compounds, possess pharmacological potential to be repurposed ...
Yunyun Lv +4 more
doaj +1 more source