Results 1 to 10 of about 13,266 (116)
HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence [PDF]
Advanced ScienceDysregulated cholesterol metabolism has been implicated in several aging‐associated disorders, including osteoarthritis (OA). 3‐Hydroxy‐3‐methylglutaryl‐CoA reductase (HMGCR) is the key enzyme in cholesterol biosynthesis, but the role of HMGCR in OA and ...
Xiaoqi Zhang +19 more
doaj +2 more sources
Viruses, 2019 Porcine circovirus type 2 (PCV2) is the etiological agent of porcine circovirus diseases and porcine circovirus-associated diseases (PCVDs/PCVADs). However, the pathogenesis of PCV2 is not fully understood.
Hongsheng Ouyang, Linzhu Ren, Guyu Niu
exaly +3 more sources
AntioxidantsThis review explores the therapeutic promise of natural compounds in modulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), a key enzyme in cholesterol synthesis. HMGCR dysregulation is implicated in dyslipidemia, cardiovascular disease, and
Yu-Ning Teng
exaly +3 more sources
On the Hypolipidemic Activity of Elicited Soybeans: Evidences Based on Computational Analysis
Indonesian Journal of Chemistry, 2022 Dietary intervention plays a significant role in regulating hyperlipidemia. Besides, elicited soybean has greater bioactive contents with numerous health benefits potential. However, there is no evidence of the hypolipidemic activity of elicited soybean.
Feri Eko Hermanto +3 more
doaj +1 more source
Frontiers in Ecology and Evolution, 2022 Comprising a major clade of Anura, toads produce and secrete numerous toxins from both the parotoid glands behind their eyes and their dorsal skin. These toxins, made of various proteins and compounds, possess pharmacological potential to be repurposed ...
Yunyun Lv +4 more
doaj +1 more source
RNA-binding protein hnRNPR reduces neuronal cholesterol levels by binding to and suppressing HMGCR [PDF]
Journal of Integrative Neuroscience, 2021 Recent studies have identified multiple RNA-binding proteins tightly associated with lipid and neuronal cholesterol metabolism and cardiovascular disorders.
John Agbo +7 more
doaj +1 more source
The Statin Target HMG-Coenzyme a Reductase (Hmgcr) Regulates Sleep Homeostasis in Drosophila
Pharmaceuticals, 2022 Statins, HMG Coenzyme A Reductase (HMGCR) inhibitors, are a first-line therapy, used to reduce hypercholesterolemia and the risk for cardiovascular events.
Ahmed M. Alsehli +8 more
doaj +1 more source
Crocetin and crocin decreased cholesterol and triglyceride content of both breast cancer tumors and cell lines [PDF]
Avicenna Journal of Phytomedicine, 2020 Objective: Inhibition of lipid metabolism in breast cancer has been suggested as an effective approach for cancer therapy. Saffron-derived crocetin (Crt) and crocin (Cro) with the known anticancer activity, have shown hypolipidemic effect in diabetes and
Seyed Ali Hashemi +2 more
doaj +1 more source
Marine Drugs, 2020 Chitooligosaccharides (COS) have a variety of biological activities due to their positively charged amino groups. Studies have shown that COS have antidiabetic effects, but their molecular mechanism has not been fully elucidated.
Qiutong Wang +7 more
doaj +1 more source
The Statin Target Hmgcr Regulates Energy Metabolism and Food Intake through Central Mechanisms
Cells, 2022 The statin drug target, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), is strongly linked to body mass index (BMI), yet how HMGCR influences BMI is not understood.
Michael J. Williams +15 more
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