Results 41 to 50 of about 14,518 (216)

Are fucoidan and alginate active substances affecting CYP7A1 and HMG CoA reductase in dyslipidemia condition? [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Dyslipidemia, characterized by abnormal plasma lipid levels, is commonly treated with statins, which may induce adverse effects. Fucoidan and alginate, bioactive marine polysaccharides, have emerged as potential natural modulators of lipid ...
Pertiwi Febriana Chandrawati, Loeki Enggar Fitri, Akhmad Sabarudin, Valentina Yurina, M. Izdad Irfani Fanada   +4 more
doaj   +1 more source

SIAH1 ubiquitination-modified HMGCR inhibits lung cancer progression and promotes drug sensitivity through cholesterol synthesis

Cancer Cell International, 2023
Backgrounds Lung cancer is one of the most frequently diagnosed cancers and the leading cause of cancer-related deaths worldwide. Deep understanding of chemoresistance will lead to remarkable progress in lung cancer treatment strategy.
Hongmei Yuan, Hongge Wu, Jing Cheng, Jie Xiong   +3 more
doaj   +1 more source

HMG-Coenzyme A Reductase as a Drug Target for the Prevention of Ankylosing Spondylitis

Frontiers in Cell and Developmental Biology, 2021
Statins are an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). Growing evidence indicates that statins may have an anti-inflammatory effect.
Zhenyu Zhong, Xiaojie Feng, Guannan Su, Liping Du, Weiting Liao, Shengyun Liu, Fuzhen Li, Xianbo Zuo, Peizeng Yang   +8 more
doaj   +1 more source

Statin-Induced Anti-HMGCR-Associated Myopathy

Journal of the American College of Cardiology, 2016
In addition to self-limited myotoxicity, statins have recently been shown to trigger an immune-mediated necrotizing myopathy (IMNM), which is distinguished from polymyositis (PM) and dermatomyositis (DM) by the absence of primary inflammation on muscle biopsy.
Pari, Basharat, Arash H, Lahouti, Julie J, Paik, Jemima, Albayda, Iago, Pinal-Fernandez, Tanmayee, Bichile, Thomas E, Lloyd, Sonye K, Danoff, Livia, Casciola-Rosen, Andrew L, Mammen, Lisa, Christopher-Stine   +10 more
openaire   +2 more sources

Targeted expression of the HMGCR in the corpus allatum rescues the hmgcr mutant phenotype.

, 2013
p[DI-3-GAL4] plus p[act-GAL4] in the same flies are sufficient to rescue the sexual dimorphism disrupted in hmgcr11635/hmgcr11635 flies (DI-3, act-GAL4; hmgcr11635/UAS-clb; hmgcr11635). This suggests a specific role for the HMGCR in the ca to control the
Jean-René Martin (23795), Yesser Hadj Belgacem (23794)   +1 more
core   +1 more source

Statin use, HMGCR expression, and breast cancer survival – The Malmö Diet and Cancer Study

, 2020
Statins, commonly used to treat hypercholesterolemia, have also been proposed as anti-cancer agents. The identification of a predictive marker is essential. The 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR), which is inhibited by statins, might
Feldt, Maria, Bjarnadottir, Olöf, Inasu, Maria, Kimbung, Siker, Elebro, Karin, Bendahl, Pär Ola, Borgquist, Signe   +6 more
core   +2 more sources

Mendelian Randomized Study of Protective Effect of Statins on Breast Cancer

Zhongliu Fangzhi Yanjiu
ObjectiveTo genetically investigate the protective effects of statins on breast cancer. MethodsInstrumental variables for the statin target gene HMGCR and five other cholesterol-regulated genes (LDLR, PCSK9, ABCG8, APOB, and NPC1L1) were obtained from ...
Di HU, Yifang SHUI, Keke MIAO, Mengquan LI   +3 more
doaj   +1 more source

Association of HMGCR inhibition with rheumatoid arthritis: a Mendelian randomization and colocalization study

Frontiers in Endocrinology, 2023
ObjectiveThe objective of this study was to investigate the association between hydroxymethylglutaryl coenzyme A reductase (HMGCR) inhibition and rheumatoid arthritis (RA) using drug-target Mendelian randomization (MR) and genetic colocalization analyses.
Li Ma, Li Ma, Yufei Du, Chao Ma, Ming Liu   +4 more
doaj   +1 more source

Therapeutic targets of hypercholesterolemia: HMGCR and LDLR.

Diabetes, metabolic syndrome and obesity : targets and therapy, 2019
Cholesterol homeostasis is critical and necessary for the body's functions. Hypercholesterolemia can lead to significant clinical problems, such as cardiovascular disease (CVD). 3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and low-density lipoprotein cholesterol receptor (LDLR) are major points of control in cholesterol homeostasis.
Ma,Shizhan, Sun,Wenxiu, Gao,Ling, Liu,Shudong   +3 more
openaire   +4 more sources

Directed expression of p[UAS-RNAi-HMGCR] specifically in the corpus allatum mimics the hmgcr mutation, by disrupting the sexual dimorphism.

, 2013
For all panels (a–g): immunostaining using a primary antibody raised against the human form of the HMGCR, revealed with a secondary antibody labeled with Cy3 (red).
Jean-René Martin (23795), Yesser Hadj Belgacem (23794)   +1 more
core   +1 more source