Results 51 to 60 of about 14,518 (216)

Table_1_Association of HMGCR inhibition with rheumatoid arthritis: a Mendelian randomization and colocalization study.docx

, 2023
ObjectiveThe objective of this study was to investigate the association between hydroxymethylglutaryl coenzyme A reductase (HMGCR) inhibition and rheumatoid arthritis (RA) using drug-target Mendelian randomization (MR) and genetic colocalization analyses.
Ming Liu (105953), Yufei Du (9657818), Chao Ma (207385), Li Ma (46633)   +3 more
core   +1 more source

Analysis of Autoantibodies to 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Using Different Technologies

Journal of Immunology Research, 2014
Diagnostic tests are needed to aid in the diagnosis of necrotizing myopathies associated with statin use. This study aimed to compare different technologies for the detection of anti-HMGCR antibodies and analyze the clinical phenotype and autoantibody ...
Lucile Musset, Makoto Miyara, Olivier Benveniste, Jean-Luc Charuel, Alexander Shikhman, Olivier Boyer, Richard Fowler, Andrew Mammen, Joe Phillips, Michael Mahler   +9 more
doaj   +1 more source

Thyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activated protein kinase in the liver

Journal of Lipid Research, 2015
Cholesterol homeostasis is strictly regulated through the modulation of HMG-CoA reductase (HMGCR), the rate-limiting enzyme of cholesterol synthesis. Phosphorylation of HMGCR inactivates it and dephosphorylation activates it. AMP-activated protein kinase
Xiujuan Zhang, Yongfeng Song, Mei Feng, Xinli Zhou, Yingli Lu, Ling Gao, Chunxiao Yu, Xiuyun Jiang, Jiajun Zhao   +8 more
doaj   +1 more source

Screening for Anti-HMGCR Antibodies in a Large Single Myositis Center Reveals Infrequent Exposure to Statins and Diversiform Presentation of the Disease

Frontiers in Immunology, 2022
BackgroundThe objective of this study is to assess the frequency of autoantibodies against 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) in a single center myositis cohort and to analyze associations with statin exposure, clinical features ...
Piotr Szczesny, Simone Barsotti, Simone Barsotti, Inger Nennesmo, Olof Danielsson, Maryam Dastmalchi, Maryam Dastmalchi, Maryam Dastmalchi   +7 more
doaj   +1 more source

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis. [PDF]

Adv Sci (Weinh)
Aberrant lipid metabolism characterizes the progression of breast cancer. Statins, the canonical agents for modulating this pathway, have been associated with improved overall survival in patients with triple‐negative breast cancer (TNBC). However, their
Su T, Li G, Guan Y, Tian Q, Qi Y, Zhang Y, Wei W, Duan X, Rui J, Zhu H, Lin Z, Xie C, Xu Z, Wu Y, Peng X, Wang Z, Chen K, Xin X, Zhang B.   +18 more
europepmc   +2 more sources

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Synthesis, function, and regulation of sterol and nonsterol isoprenoids

Frontiers in Molecular Biosciences, 2022
Cholesterol, the bulk end-product of the mevalonate pathway, is a key component of cellular membranes and lipoproteins that transport lipids throughout the body. It is also a precursor of steroid hormones, vitamin D, and bile acids.
Rebecca Faulkner, Youngah Jo
doaj   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Insulin signaling pathway controls the sexual dimorphism via HMGCR.

, 2013
a) Immunostaining using primary antibodies against the InR and/or HMGCR, revealed by secondary antibodies labeled with FITC (green) or Cy3 (red) respectively. HMGCR and InR are colocalized in the same cells of the ca. Blocking the expression of the HMGCR
Jean-René Martin (23795), Yesser Hadj Belgacem (23794)   +1 more
core   +1 more source

Association of Common and Rare Genetic Variation in the 3‐Hydroxy‐3‐Methylglutaryl Coenzyme A Reductase Gene and Cataract Risk

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Results from animal models and observational studies have raised concerns regarding the potential cataractogenic effects of statin treatment.
Jonas Ghouse, Gustav Ahlberg, Anne Guldhammer Skov, Henning Bundgaard, Morten S. Olesen   +4 more
doaj   +1 more source