Results 31 to 40 of about 14,518 (216)
Animals, 2023 This study aimed to investigate the effect of HMGCR inhibitors on egg yolk cholesterol content and its biological mechanisms. Four groups of 180-day-old laying hens (n = 8 cages/group, 6 laying hens/cage) were fed a corn/soybean-based diet (control) and ...
Huanbin Wang +4 more
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The Role of HMGCR Alternative Splicing in Statin Efficacy [PDF]
Trends in Cardiovascular Medicine, 2009 Statins, or 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) inhibitors, are widely prescribed to lower plasma cholesterol levels and reduce cardiovascular disease risk. Despite the well-documented efficacy of statins, there is large interindividual variation in response.
Marisa Wong, Medina, Ronald M, Krauss
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Anti-HMGCR antibodies in systemic sclerosis
Medicine, 2016 The objective of this study was to investigate the frequency of autoantibodies to hydroxymethylglutaryl coenzyme A reductase (HMGCR) in systemic sclerosis (SSc) and associations with inflammatory myositis and statin exposure.This was a cross-sectional, multicenter study of 306 subjects from the Canadian Scleroderma Research Group cohort who had ...
Hudson, Marie +6 more
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Ubiquitination and proteasomal degradation of HMGCR in hPIV1 infected cells.
, 2021 (A) A549 cells were infected with hPIV1 or hPIV3 at an MOI of 5 for 2 days. Cells were then labeled with 35S-Met/Cys for 30 min and chased for either 2 or 4 h. HMGCR stability was analyzed by radio-immunoprecipitation.
Yuki Kurebayashi (11441957) +6 more
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Open Life Sciences, 2020 LINC00202 is a newly identified long noncoding RNA (lncRNA) and has been demonstrated to involve in the progression of retinoblastoma (RB). Here, we further explored the role and the underlying molecular mechanism of LINC00202 on RB malignant properties ...
Wu Aimin +3 more
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Clinical Characteristics of Anti-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Antibodies in Chinese Patients with Idiopathic Inflammatory Myopathies. [PDF]
PLoS ONE, 2015 The objective of this study was to detect the prevalence of anti-3-hydroxyl-3- methylglutaryl coenzyme A reductase (anti-HMGCR) antibodies in Chinese patients with idiopathic inflammatory myopathies (IIMs), and to analyze the clinical features of the ...
Yongpeng Ge +4 more
doaj +1 more source
eLife, 2018 Mammalian HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the cholesterol biosynthetic pathway and the therapeutic target of statins, is post-transcriptionally regulated by sterol-accelerated degradation.
Sam A Menzies +6 more
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Cancer Management and Research, 2021 Xueyao Huang,1,2 Xuan Wei,1 Sijing Qiao,1,2 Xue Zhang,1,2 Rui Li,1 Shunxue Hu,3 Hongluan Mao,1,2 Peishu Liu1,2 1Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, People’s Republic of China; 2Shandong ...
Huang X +7 more
doaj
Association between GPX4 and HMGCR gene expression and cell proliferation in atypical hyperplasia of the breast [PDF]
Exploration of MedicineAim: Using a dataset available from the NCBI Gene Expression Omnibus Repository, this in silico study investigated the differential expression of GPX4, the gene coding for the detoxifying enzyme glutathione peroxidase paired samples of AH (atypical ...
Danila Coradini
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Development of a Microminipig Model of Atherosclerosis for the Evaluation of a HMGCR Inhibitor
In Vivo, 2023 Atherosclerosis is known as a major risk factor for cardiovascular disease, and development of an animal model of atherosclerosis is required to investigate its clinical pathogenesis. We studied the optimal amount of cholesterol in the diet and the optimal experimental period for development of a Microminipig model of atherosclerosis for the evaluation
Tomonobu, Yamada +6 more
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