Results 31 to 40 of about 15,635 (172)

Are fucoidan and alginate active substances affecting CYP7A1 and HMG CoA reductase in dyslipidemia condition? [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Dyslipidemia, characterized by abnormal plasma lipid levels, is commonly treated with statins, which may induce adverse effects. Fucoidan and alginate, bioactive marine polysaccharides, have emerged as potential natural modulators of lipid ...
Pertiwi Febriana Chandrawati, Loeki Enggar Fitri, Akhmad Sabarudin, Valentina Yurina, M. Izdad Irfani Fanada   +4 more
doaj   +1 more source

Evaluating the expression of HMGCR in HER2 negative and HER2 positive breast cancer [PDF]

, 2022
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) is the rate-limiting enzyme in cholesterol biosynthesis pathway that has been associated with cancer development. Although the connection between HMGCR and HER2 has been established, the function of
Drahman, Rosmaizan
core   +1 more source

HMG-Coenzyme A Reductase as a Drug Target for the Prevention of Ankylosing Spondylitis

Frontiers in Cell and Developmental Biology, 2021
Statins are an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). Growing evidence indicates that statins may have an anti-inflammatory effect.
Zhenyu Zhong, Xiaojie Feng, Guannan Su, Liping Du, Weiting Liao, Shengyun Liu, Fuzhen Li, Xianbo Zuo, Peizeng Yang   +8 more
doaj   +1 more source

Understanding the Regulation of HMGCR

, 2013
Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), the rate limiting enzyme of the mevalonate (MVA) pathway, and are also known to possess tumour-specific apoptotic effects.
Hassanabad, Ali Fatehi
core   +2 more sources

Mendelian Randomized Study of Protective Effect of Statins on Breast Cancer

Zhongliu Fangzhi Yanjiu
ObjectiveTo genetically investigate the protective effects of statins on breast cancer. MethodsInstrumental variables for the statin target gene HMGCR and five other cholesterol-regulated genes (LDLR, PCSK9, ABCG8, APOB, and NPC1L1) were obtained from ...
Di HU, Yifang SHUI, Keke MIAO, Mengquan LI   +3 more
doaj   +1 more source

SIAH1 ubiquitination-modified HMGCR inhibits lung cancer progression and promotes drug sensitivity through cholesterol synthesis

Cancer Cell International, 2023
Backgrounds Lung cancer is one of the most frequently diagnosed cancers and the leading cause of cancer-related deaths worldwide. Deep understanding of chemoresistance will lead to remarkable progress in lung cancer treatment strategy.
Hongmei Yuan, Hongge Wu, Jing Cheng, Jie Xiong   +3 more
doaj   +1 more source

Targeted expression of the HMGCR in the corpus allatum rescues the hmgcr mutant phenotype.

, 2013
p[DI-3-GAL4] plus p[act-GAL4] in the same flies are sufficient to rescue the sexual dimorphism disrupted in hmgcr11635/hmgcr11635 flies (DI-3, act-GAL4; hmgcr11635/UAS-clb; hmgcr11635). This suggests a specific role for the HMGCR in the ca to control the
Jean-René Martin (23795), Yesser Hadj Belgacem (23794)   +1 more
core   +1 more source

Thyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activated protein kinase in the liver

Journal of Lipid Research, 2015
Cholesterol homeostasis is strictly regulated through the modulation of HMG-CoA reductase (HMGCR), the rate-limiting enzyme of cholesterol synthesis. Phosphorylation of HMGCR inactivates it and dephosphorylation activates it. AMP-activated protein kinase
Xiujuan Zhang, Yongfeng Song, Mei Feng, Xinli Zhou, Yingli Lu, Ling Gao, Chunxiao Yu, Xiuyun Jiang, Jiajun Zhao   +8 more
doaj   +1 more source

Association of HMGCR inhibition with rheumatoid arthritis: a Mendelian randomization and colocalization study

Frontiers in Endocrinology, 2023
ObjectiveThe objective of this study was to investigate the association between hydroxymethylglutaryl coenzyme A reductase (HMGCR) inhibition and rheumatoid arthritis (RA) using drug-target Mendelian randomization (MR) and genetic colocalization analyses.
Li Ma, Li Ma, Yufei Du, Chao Ma, Ming Liu   +4 more
doaj   +1 more source

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source