The Statin Target Hmgcr Regulates Energy Metabolism and Food Intake through Central Mechanisms
Cells, 2022 The statin drug target, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), is strongly linked to body mass index (BMI), yet how HMGCR influences BMI is not understood.
Michael J. Williams +15 more
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The Statin Target HMG-Coenzyme a Reductase (Hmgcr) Regulates Sleep Homeostasis in Drosophila
Pharmaceuticals, 2022 Statins, HMG Coenzyme A Reductase (HMGCR) inhibitors, are a first-line therapy, used to reduce hypercholesterolemia and the risk for cardiovascular events.
Ahmed M. Alsehli +8 more
doaj +2 more sources
Anti-HMGCR myopathy: barriers to prompt recognition [PDF]
Practical Neurology, 2022 Anti-HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase) myopathy is an immune-mediated necrotising myopathy. Atypical presentations hinder its recognition and its prompt treatment. We present two patients with atypical clinical or pathological features.
Andrea Barp +5 more
openaire +4 more sources
Hmgcr in the corpus allatum controls sexual dimorphism of locomotor activity and body size via the insulin pathway in Drosophila. [PDF]
PLoS ONE, 2007 The insulin signaling pathway has been implicated in several physiological and developmental processes. In mammals, it controls expression of 3-Hydroxy-3-Methylglutaryl CoA Reductase (HMGCR), a key enzyme in cholesterol biosynthesis.
Yesser Hadj Belgacem, Jean-René Martin
doaj +2 more sources
Regulation of HMGCR in the mevalonte pathway
, 2012 A pathway diagram describing the regulation of HMGCR and its impact on the cholesterol synthesis pathway, obtained from a review of the published literature as part of the project work for our MSc in Genomics and Pathway Biology. The pathway is presented in SBGN notation. This pathway diagram has not been peer reviewed.
Pappa, Eleana +4 more
openaire +2 more sources
CyTA - Journal of FoodThis study investigated the impact of Oleanolic Acid (OA) on cholesterol metabolism and. MTT assays demonstrated that OA had no cytotoxic effects on HepG2 cells at concentrations below 20 μM.
Fang Luo +7 more
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Diagnostic and Therapeutic Challenges in Statin-Induced Necrotizing Autoimmune Myopathy in an Elderly Patient: A Rare Case Report. [PDF]
Clin Case RepABSTRACT We present the case of a 78‐year‐old woman with metabolic syndrome and a history of multiple ischemic strokes who developed progressive symmetrical proximal muscle weakness, predominantly affecting the lower extremities, while on atorvastatin.
Shrestha N, Hassan A, Evans JA.
europepmc +2 more sources
BMC ImmunologyBackground Immune-mediated necrotizing myopathy (IMNM) is an idiopathic inflammatory myopathy (IIM). Though patients with IMNM were not considered to show skin rash, several reports have showed atypical skin conditions in patients with anti-3-hydroxy-3 ...
Takashi Kurashige +9 more
doaj +2 more sources
RNA-binding protein hnRNPR reduces neuronal cholesterol levels by binding to and suppressing HMGCR [PDF]
Journal of Integrative Neuroscience, 2021 Recent studies have identified multiple RNA-binding proteins tightly associated with lipid and neuronal cholesterol metabolism and cardiovascular disorders.
John Agbo +7 more
doaj +1 more source
Crocetin and crocin decreased cholesterol and triglyceride content of both breast cancer tumors and cell lines [PDF]
Avicenna Journal of Phytomedicine, 2020 Objective: Inhibition of lipid metabolism in breast cancer has been suggested as an effective approach for cancer therapy. Saffron-derived crocetin (Crt) and crocin (Cro) with the known anticancer activity, have shown hypolipidemic effect in diabetes and
Seyed Ali Hashemi +2 more
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