Results 11 to 20 of about 15,635 (172)

Anti-HMGCR Specificity of HALIP: A Confirmatory Study [PDF]

Journal of Immunology Research, 2020
A distinctive new indirect immunofluorescence pattern in liver tissue has been associated with anti-HMGCR autoantibodies. It is known as HALIP (HMGCR Associated Liver Immunofluorescence Pattern).
Andrés Baucells, Maria Angeles Martínez, Marcelo Alvarado-Cardenas, Anaís Mariscal, Laura Martinez-Martinez, Cándido Juárez, Albert Selva-O’Callaghan   +6 more
doaj   +2 more sources

Hmgcr in the corpus allatum controls sexual dimorphism of locomotor activity and body size via the insulin pathway in Drosophila. [PDF]

PLoS ONE, 2007
The insulin signaling pathway has been implicated in several physiological and developmental processes. In mammals, it controls expression of 3-Hydroxy-3-Methylglutaryl CoA Reductase (HMGCR), a key enzyme in cholesterol biosynthesis.
Yesser Hadj Belgacem, Jean-René Martin
doaj   +2 more sources

Oleanolic acid inhibits cholesterol synthesis by suppressing the expression and enzymatic activity of HMGCR

CyTA - Journal of Food
This study investigated the impact of Oleanolic Acid (OA) on cholesterol metabolism and. MTT assays demonstrated that OA had no cytotoxic effects on HepG2 cells at concentrations below 20 μM.
Fang Luo, WenLuer Meng, Ruo-Shi Hao, Xiangxuan Yang, Jinbo Yang, Ye-Wei Huang, Jun Sheng, Xuanjun Wang   +7 more
doaj   +2 more sources

Atypical skin conditions of the neck and back as a dermal manifestation of anti-HMGCR antibody-positive myopathy

BMC Immunology
Background Immune-mediated necrotizing myopathy (IMNM) is an idiopathic inflammatory myopathy (IIM). Though patients with IMNM were not considered to show skin rash, several reports have showed atypical skin conditions in patients with anti-3-hydroxy-3 ...
Takashi Kurashige, Rie Nakamura, Tomomi Murao, Naoko Mine, Mayu Sato, Riho Katsumata, Yuhei Kanaya, Yoriko Dodo, Tomohito Sugiura, Tomohiko Ohshita   +9 more
doaj   +2 more sources

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Reduced HMGCR expression in hPIV1-infected cells.

, 2021
(A) A549 cells were either mock- or hPIV1-infected at an MOI of 5 and expression levels of HMGCR, SQLE, viral NP and β-actin were assessed by immunoblotting. (B) HPBE cells were either mock- or hPIV1-infected at an MOI of 5 and expression levels of HMGCR,
Yuki Kurebayashi (11441957), Michael Lutz (11441963), Nicholas Lim (716671), Shringkhala Bajimaya (11441960), Masahiro Watanabe (480517), Megan Dunagan (6030191), Toru Takimoto (248125)   +6 more
core   +1 more source

Increased small extracellular vesicle secretion after chemotherapy via upregulation of cholesterol metabolism in acute myeloid leukaemia

Journal of Extracellular Vesicles, 2020
Most patients with acute myeloid leukaemia (AML) experience disease recurrence after chemotherapy largely due to the development of drug resistance. Small extracellular vesicles (sEVs) are known to play a significant role in leukaemia drug resistance by ...
Chang-Sook Hong, Emily Jeong, Michael Boyiadzis, Theresa L. Whiteside   +3 more
doaj   +1 more source

Anti-HMGCR myopathy: barriers to prompt recognition [PDF]

, 2022
Anti-HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase) myopathy is an immune-mediated necrotising myopathy. Atypical presentations hinder its recognition and its prompt treatment.
Barp, Andrea, Hanna, Michael G, Merve, Ashirwad, Bugiardini, Enrico, Shah, Sachit, Desikan, Mahalekshmi   +5 more
core   +1 more source

DENV up-regulates the HMG-CoA reductase activity through the impairment of AMPK phosphorylation: A potential antiviral target. [PDF]

PLoS Pathogens, 2017
Dengue is the most common mosquito-borne viral disease in humans. Changes of lipid-related metabolites in endoplasmic reticulum of dengue virus (DENV) infected cells have been associated with replicative complexes formation.
Rubén Soto-Acosta, Patricia Bautista-Carbajal, Margot Cervantes-Salazar, Antonio H Angel-Ambrocio, Rosa M Del Angel   +4 more
doaj   +1 more source

Defective AMPK regulation of cholesterol metabolism accelerates atherosclerosis by promoting HSPC mobilization and myelopoiesis

Molecular Metabolism, 2022
Objectives: Dysregulation of cholesterol metabolism in the liver and hematopoietic stem and progenitor cells (HSPCs) promotes atherosclerosis development.
Man K.S. Lee, Olivia D. Cooney, Xuzhu Lin, Shaktypreya Nadarajah, Dragana Dragoljevic, Kevin Huynh, Danise-Ann Onda, Sandra Galic, Peter J. Meikle, Thomas Edlund, Morgan D. Fullerton, Bruce E. Kemp, Andrew J. Murphy, Kim Loh   +13 more
doaj   +1 more source