Results 21 to 30 of about 15,635 (172)
Anti-HMGCR Immune-Mediated Necrotising Myopathy: Addressing the Remaining Issues
, 2023 The discovery of autoantibodies directed against the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) enzyme has defined a sub-set of immune-mediated necrotising myopathy (IMNM) which is strongly associated with exposure to statin medications.
Chinoy, Hector; id_orcid, Khoo, Thomas
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Animals, 2023 This study aimed to investigate the effect of HMGCR inhibitors on egg yolk cholesterol content and its biological mechanisms. Four groups of 180-day-old laying hens (n = 8 cages/group, 6 laying hens/cage) were fed a corn/soybean-based diet (control) and ...
Huanbin Wang +4 more
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Anti-HMGCR antibodies and asymptomatic hyperCKemia. A case report
, 2021 Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) related myositis is a form of immune-mediated necrotizing myopathy (IMNM). Anti-HMGCR autoantibodies target HMGCR, a glycoprotein linked to the endoplasmic reticulum implied in the cholesterol ...
Ali G. +4 more
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Open Life Sciences, 2020 LINC00202 is a newly identified long noncoding RNA (lncRNA) and has been demonstrated to involve in the progression of retinoblastoma (RB). Here, we further explored the role and the underlying molecular mechanism of LINC00202 on RB malignant properties ...
Wu Aimin +3 more
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Ubiquitination and proteasomal degradation of HMGCR in hPIV1 infected cells.
, 2021 (A) A549 cells were infected with hPIV1 or hPIV3 at an MOI of 5 for 2 days. Cells were then labeled with 35S-Met/Cys for 30 min and chased for either 2 or 4 h. HMGCR stability was analyzed by radio-immunoprecipitation.
Yuki Kurebayashi (11441957) +6 more
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eLife, 2018 Mammalian HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the cholesterol biosynthetic pathway and the therapeutic target of statins, is post-transcriptionally regulated by sterol-accelerated degradation.
Sam A Menzies +6 more
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Cancer Management and Research, 2021 Xueyao Huang,1,2 Xuan Wei,1 Sijing Qiao,1,2 Xue Zhang,1,2 Rui Li,1 Shunxue Hu,3 Hongluan Mao,1,2 Peishu Liu1,2 1Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, People’s Republic of China; 2Shandong ...
Huang X +7 more
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Clinical Characteristics of Anti-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Antibodies in Chinese Patients with Idiopathic Inflammatory Myopathies. [PDF]
PLoS ONE, 2015 The objective of this study was to detect the prevalence of anti-3-hydroxyl-3- methylglutaryl coenzyme A reductase (anti-HMGCR) antibodies in Chinese patients with idiopathic inflammatory myopathies (IIMs), and to analyze the clinical features of the ...
Yongpeng Ge +4 more
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Electroacupuncture regulates hepatic cholesterol synthesis by HMGCR deubiquitination in rats
, 2023 This experiment was designed to explore the effect and mechanism of electroacupuncture (EA) for hyperlipidemia and hepatic cholesterol synthesis in rats.
Xiao-li Pan +3 more
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Association between GPX4 and HMGCR gene expression and cell proliferation in atypical hyperplasia of the breast [PDF]
Exploration of MedicineAim: Using a dataset available from the NCBI Gene Expression Omnibus Repository, this in silico study investigated the differential expression of GPX4, the gene coding for the detoxifying enzyme glutathione peroxidase paired samples of AH (atypical ...
Danila Coradini
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