Results 21 to 30 of about 14,518 (216)
Hepatology, EarlyView., 2022 Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince +30 more
wiley +1 more source
Marine Drugs, 2020 Chitooligosaccharides (COS) have a variety of biological activities due to their positively charged amino groups. Studies have shown that COS have antidiabetic effects, but their molecular mechanism has not been fully elucidated.
Qiutong Wang +7 more
doaj +1 more source
Myopathy with anti-HMGCR antibodies [PDF]
Neurology Neuroimmunology & Neuroinflammation, 2015 To analyze clinical features and myopathology changes in muscle fibers, connective tissue, and vessels in 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibody-associated myopathies.Retrospective review of records and myopathologic features of 49 consecutive patients with myopathies and serum HMGCR antibodies.Clinical features included onset
Alshehri, Ali +3 more
openaire +3 more sources
Reduced HMGCR expression in hPIV1-infected cells.
, 2021 (A) A549 cells were either mock- or hPIV1-infected at an MOI of 5 and expression levels of HMGCR, SQLE, viral NP and β-actin were assessed by immunoblotting. (B) HPBE cells were either mock- or hPIV1-infected at an MOI of 5 and expression levels of HMGCR,
Yuki Kurebayashi (11441957) +6 more
core +1 more source
Journal of Extracellular Vesicles, 2020 Most patients with acute myeloid leukaemia (AML) experience disease recurrence after chemotherapy largely due to the development of drug resistance. Small extracellular vesicles (sEVs) are known to play a significant role in leukaemia drug resistance by ...
Chang-Sook Hong +3 more
doaj +1 more source
Journal of Neuromuscular Diseases, 2018 Anti-HMGCR myopathy was first recognized and characterized in patients with a history of statin exposure and immune-mediated necrotizing myopathy. After the discovery of anti-HMGCR autoantibodies, several international groups identified and characterized more patients, expanding the phenotypic spectrum of this disease to include pediatric patients and ...
Mohassel, Payam, Mammen, Andrew L.
openaire +3 more sources
Molecular Metabolism, 2022 Objectives: Dysregulation of cholesterol metabolism in the liver and hematopoietic stem and progenitor cells (HSPCs) promotes atherosclerosis development.
Man K.S. Lee +13 more
doaj +1 more source
DENV up-regulates the HMG-CoA reductase activity through the impairment of AMPK phosphorylation: A potential antiviral target. [PDF]
PLoS Pathogens, 2017 Dengue is the most common mosquito-borne viral disease in humans. Changes of lipid-related metabolites in endoplasmic reticulum of dengue virus (DENV) infected cells have been associated with replicative complexes formation.
Rubén Soto-Acosta +4 more
doaj +1 more source
Anti-HMGCR Immune-Mediated Necrotising Myopathy: Addressing the Remaining Issues
, 2023 The discovery of autoantibodies directed against the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) enzyme has defined a sub-set of immune-mediated necrotising myopathy (IMNM) which is strongly associated with exposure to statin medications.
Chinoy, Hector; id_orcid, Khoo, Thomas
core +1 more source
Electroacupuncture regulates hepatic cholesterol synthesis by HMGCR deubiquitination in rats
, 2023 This experiment was designed to explore the effect and mechanism of electroacupuncture (EA) for hyperlipidemia and hepatic cholesterol synthesis in rats.
Xiao-li Pan +3 more
core +1 more source