Results 71 to 80 of about 15,635 (172)
CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems
The FEBS Journal, EarlyView.Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén +11 more
wiley +1 more source
Schematic illustration of the role of UBIAD1 in sterol-accelerated degradation of HMGCR.
, 2019 Sterols induce ER-anchored Insig to bind HMGCR, which is ubiquitinated by Insig-associated E3 ubiquitin ligase (gp78, Trc8, or RNF145), leading to the degradation of HMGCR. In contrast to WT UBIAD1 that is efficiently transported to Golgi from ER.
Shi-You Jiang (395689) +9 more
core +1 more source
Journal of Periodontal Research, EarlyView.This systematic review evaluated drug‐target Mendelian randomisation studies on periodontitis. Twelve studies identified host‐response‐related targets mainly involved in inflammatory, complement, and immune pathways. Although some targets were linked to existing drugs, the evidence remains preliminary and heterogeneous, requiring replication and ...
Luigi Nibali +4 more
wiley +1 more source
Autoimmune anti-HMGCR myopathy: a rare but disabling complication of statin therapy
, 2022 Presentation An 85-year-old farmer developed disabling progressive proximal limb weakness and dysphagia after 10 years of statin therapy. Diagnosis Creatine kinase was elevated, and electromyography demonstrated myopathic abnormalities.
Patrick Moloney (7948142) +6 more
core +3 more sources
Tzu Chi Medical JournalObjectives: 3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is a rate-limiting enzyme involved in cholesterol synthesis. The common HMGCR variants are associated with low-density lipoprotein cholesterol (LDL-C) levels.
Lung-An Hsu +5 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Therapies targeting the glucagon receptor are being explored for obesity treatment, yet most preclinical studies remain male biased. In this study, Merrild and Johansen et al. show that in diet‐induced obese wild‐type mice a long‐acting glucagon analogue (LA‐Gcg) elicits sexually dimorphic effects on weight loss, food intake ...
Christoffer Merrild +3 more
wiley +1 more source
The sexual dimorphism in locomotor activity is disrupted in hmgcr mutant.
, 2013 a) Flies homozygous for a P element inserted in the 3′ region of the hmgcr gene (hmgcr11635/hmgcr11635) do not exhibit a sexually dimorphic start/stop number.
Jean-René Martin (23795) +1 more
core +1 more source
A novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) splice variant with an alternative exon 1 potentially encoding an extended N-terminus [PDF]
, 2012 Background The major rate-limiting enzyme for de novo cholesterol synthesis is 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR).
Marianne K Kringen +9 more
core +1 more source
Journal of Lipid Research, 2019 Sterol-regulated HMG-CoA reductase (HMGCR) degradation and SREBP-2 cleavage are two major feedback regulatory mechanisms governing cholesterol biosynthesis.
Liang Chen +10 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Skeletal muscle wasting conditions are characterized by muscle fibre atrophy, mitochondrial respiratory dysfunction, mitochondrial depletion and fragmentation of acetylcholine receptor (AChR) cluster at the neuromuscular junction.
Maya Semel +10 more
wiley +1 more source