Results 71 to 80 of about 14,518 (216)
Anti-HMGCR myopathy may resemble limb-girdle muscular dystrophy
, 2018 International audienceObjective To determine the prevalence and clinical features of anti-HMGCR myopathy among patients with presumed limb-girdle muscular dystrophy (LGMD) in whom genetic testing has failed to elucidate causative mutations.
Fequiere, Pierre +24 more
core +1 more source
Navigating the Shallows and Rapids of Cholesterol Synthesis Downstream of HMGCR
Journal of Nutritional Science and Vitaminology, 2015 Cholesterol is vital for human life, but its levels must be tightly regulated. Too little cholesterol leads to developmental disorders, but too much is widely appreciated as contributing to heart disease. Levels are regulated through the coordinated control of cholesterol synthesis, uptake and efflux. Here, we focus on cholesterol synthesis.
SHARPE, Laura J. +4 more
openaire +3 more sources
Anti-HMGCR myopathy: clinical and histopathological features, and prognosis
Current Opinion in Rheumatology, 2021 Purpose of review This review aims to describe clinical and pathological features, prognosis and treatment in patients with anti-HMGCR antibody positive immune-mediated necrotizing myopathy (HMGCR-IMNM) based on recent findings.
openaire +3 more sources
Plant Biotechnology Journal, Volume 24, Issue 7, Page 4528-4545, July 2026.ABSTRACT Protoberberine alkaloids are a characteristic group of natural products in Coptis plants known for their notable pharmacological activities. However, the structural similarity and the substrate promiscuity of their biosynthetic enzymes have left the precise synthetic pathways remain unclarified, posing challenges to regulate product formation.
Jun Song +14 more
wiley +1 more source
AMPK-mediated HMGCR regulation of cholesterol metabolism in macrophages
, 2017 Atherosclerosis, the accumulation of cholesterol-loaded macrophages (foam cells) in the arteries, leads to cardiovascular disease, which is the leading cause of mortality in the developed world.
LeBlond, Nicholas D. +4 more
core +1 more source
Understanding the Regulation of HMGCR
, 2013 Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), the rate limiting enzyme of the mevalonate (MVA) pathway, and are also known to possess tumour-specific apoptotic effects.
Hassanabad, Ali Fatehi
core +1 more source
APOE and Cerebral Microbleeds: Insights Into Causal Proteins and Therapeutic Targets
Brain and Behavior, Volume 16, Issue 6, June 2026.This study identifies APOE as a key causal protein for cerebral microbleeds (CMBs). By integrating Mendelian randomization (MR) and colocalization analysis of the plasma proteome from UKB‐PPP and deCODE datasets, we provide genetic evidence that circulating APOE levels are causally linked to CMB susceptibility. Furthermore, protein–protein interaction (
Lei Yang +8 more
wiley +1 more source
Thrombosis Journal, 2022 Objective Long non-coding RNA (lncRNA) essentially controls many physiological and pathological processes of deep vein thrombosis (DVT). Based on that, lncRNA taurine upregulated gene 1 (TUG1)-involved angiogenesis of endothelial progenitor cells (EPCs ...
Yaping Feng +6 more
doaj +1 more source
HSP90 interacts with HMGCR and promotes the progression of hepatocellular carcinoma
Molecular Medicine Reports, 2018 Heat shock protein 90 (HSP90) has been reported to promote the growth and inhibit apoptosis of hepatocellular carcinoma (HCC) cells. However, the underlying mechanisms are not fully understood. Immunostaining of the tissue array demonstrated that HSP90 was upregulated in HCC clinical samples and was associated with clinical features.
Li, Dong +5 more
openaire +3 more sources
Disease Models & Mechanisms, 2013 SUMMARY Lipid disorders pose therapeutic challenges. Previously we discovered that mutation of the hepatocyte β-hydroxybutyrate transporter Slc16a6a in zebrafish causes hepatic steatosis during fasting, marked by increased hepatic triacylglycerol, but ...
Santhosh Karanth +3 more
doaj +1 more source