Results 91 to 100 of about 15,635 (172)

Peroxisomal Localization of a Truncated HMG-CoA Reductase under Low Cholesterol Conditions

Biomolecules
3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase, HMGCR) is one of the rate-limiting enzymes in the mevalonate pathway required for cholesterol biosynthesis.
Jianqiu Wang, Markus Kunze, Andrea Villoria-González, Isabelle Weinhofer, Johannes Berger   +4 more
doaj   +1 more source

Circulating citrate as a mediator in the relationship between HMGCR inhibitors and chronic hepatitis B: a Mendelian randomization study

Scientific Reports
Observational studies have found that HMGCR inhibitors can be used to treat chronic viral hepatitis. In this study, to explore the potential mechanism of HMGCR inhibitors in treating Chronic hepatitis B (CHB), two-sample and two-step Mendelian ...
Lili Zhang, Yuming Li, Ying Li
doaj   +1 more source

UBIAD1 (G186R) blocks the ubiquitination and degradation of HMGCR.

, 2019
(A) Effects of human wild-type (WT) UBIAD1 and mutated UBIAD1 (G186R) (equivalent to mouse G184R) on HMGCR protein level. HEK-293 cells stably expressing human (homo sapiens, Hs) WT UBIAD1-TAP and UBIAD1 (G186R)-TAP, respectively, were depleted of ...
Shi-You Jiang (395689), Chao Jiang (122046), Suqian Wu (3944753), Wei Qi (132539), Jiaxu Hong (768460), Jing-Jie Tang (666252), Bao-Liang Song (666256), Xu Xiao (314389), Jianjiang Xu (647147), Jie Luo (95251)   +9 more
core   +1 more source

Variation in PCSK9 and HMGCR and Risk of Cardiovascular Disease and Diabetes [PDF]

, 2016
Background: Pharmacologic inhibitors of the proprotein convertase subtilisin-kexin type 9 (PCSK9) are in clinical trials for the treatment of coronary artery disease.
Brook, Robert, S. Fazio, Sabatine, Marc S, Catapano, Alberico L., Fazio, Sergio, Giugliano, Robert, R. D. Brook, A.L. Catapano, J. G. Robinson, R. P. Giugliano, Voros, Szilard, S. Voros, Neff, David, Davey Smith, George, M. J. Chapman, Robinson, Jennifer, Chapman, John, Ference, Brian, G. D. Smith, B. A. Ference, D. R. Neff, M. S. Sabatine   +21 more
core   +1 more source

Anti-HMGCR Autoantibodies in Juvenile Idiopathic Inflammatory Myopathies Identify a Rare but Clinically Important Subset of Patients [PDF]

, 2017
OBJECTIVE: We aimed to establish the prevalence and clinical associations of anti-HMG-CoA-reductase (anti-HMGCR) in a large UK cohort with juvenile myositis.METHODS: There were 381 patients investigated for anti-HMGCR using ELISA.RESULTS: Anti-HMGCR ...
Wood, Mark, Warrier, Kishore, Thomas S. Jacques, Tansley, Sarah L, Lucy R. Wedderburn, Sarah L. Tansley, Jacques, Thomas S, Stefania Simou, Simou, Stefania, McHugh, Neil J, Mark Wood, Kishore Warrier, Neil J. McHugh, Pilkington, Clarissa, Clarissa Pilkington, Betteridge, Zoe E, Wedderburn, Lucy R, Zoe E. Betteridge   +17 more
core   +1 more source

Regulation of HMGCR in the mevalonte pathway

, 2012
A pathway diagram describing the regulation of HMGCR and its impact on the cholesterol synthesis pathway, obtained from a review of the published literature as part of the project work for our MSc in Genomics and Pathway Biology. The pathway is presented
Eleana Pappa (101053), Douglas Roy (101052), Steven Watterson (100045), Alexander Mazein (100093), Peter Ghazal (100084)   +4 more
core   +1 more source

Virtual screening and evaluation of bioactive peptides from Haliotis discus hannai as potential HMGCR inhibitors for hyperlipidemia treatment

Frontiers in Nutrition
IntroductionHyperlipidemia remains a major disease threatening global public health. The morbidity and mortality associated with cardiovascular diseases have been increasing.
Kun Qiao, Lina Liu, Yihui Chen, Qiongmei Huang, Bei Chen, Jingna Wu, Wenmei Huang, Zhiyu Liu   +7 more
doaj   +1 more source

Human hydroxymethylglutaryl-coenzyme A reductase (HMGCR) and statin sensitivity

, 2010
331-339While statins, hydroxymethylglutaryl-coenzyme A reductase (HMGCR) inhibitors, are clinically proven to reduce plasma cholesterol levels, a wide variation in inter-individual response to statin therapy has been observed.
Seidle, Heather, Jawaid, Safdar, Gertz, Monica, Couch, Robin D, Corsino, Carlin, Cheung, Jamie   +5 more
core  

Schnyder corneal dystrophy-associated UBIAD1 mutations cause corneal cholesterol accumulation by stabilizing HMG-CoA reductase.

PLoS Genetics, 2019
Schnyder corneal dystrophy (SCD) is a rare genetic eye disease characterized by corneal opacification resulted from deposition of excess free cholesterol. UbiA prenyltransferase domain-containing protein-1 (UBIAD1) is an enzyme catalyzing biosynthesis of
Shi-You Jiang, Jing-Jie Tang, Xu Xiao, Wei Qi, Suqian Wu, Chao Jiang, Jiaxu Hong, Jianjiang Xu, Bao-Liang Song, Jie Luo   +9 more
doaj   +1 more source

Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis

, 2017
Objective-The cellular demand for cholesterol requires control of its biosynthesis by the mevalonate pathway. Regulation of HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase), a rate-limiting enzyme in this pathway and the target of statins, is a ...
Marlene van den Berg, Elmer Stickel, Martina Moeton, van den Berg, Marlene, Joseph Roitelman, Zelcer, Noam, Gelberg-Etel, Hila, Noam Zelcer, Anke Loregger, Thijn Brummelkamp, Tan, Josephine, Roitelman, Joseph, Raaben, Matthijs, Loregger, Anke, Scheij, Saskia, Brummelkamp, Thijn, Hila Gelberg-Etel, Stickel, Elmer, Saskia Scheij, Josephine Tan, Moeton, Martina, Matthijs Raaben   +21 more
core   +1 more source