Results 91 to 100 of about 14,518 (216)

Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing[S]

Journal of Lipid Research, 2019
Sterol-regulated HMG-CoA reductase (HMGCR) degradation and SREBP-2 cleavage are two major feedback regulatory mechanisms governing cholesterol biosynthesis.
Liang Chen, Mei-Yan Ma, Ming Sun, Lu-Yi Jiang, Xue-Tong Zhao, Xian-Xiu Fang, Sin Man Lam, Guang-Hou Shui, Jie Luo, Xiong-Jie Shi, Bao-Liang Song   +10 more
doaj   +1 more source

Tumour‐Derived Extracellular Vesicles Induce Diffuse Large B‐Cell Lymphoma Progression Through Macrophage‐Mediated MDSC Accumulation

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Elevated peripheral myeloid‐derived suppressor cells (MDSCs) predicted suppressed anti‐tumour immunity and poor prognosis in diffuse large B‐cell lymphoma (DLBCL) patients. Here we demonstrated that tumour‐derived extracellular vesicles (EVs) served as a messenger, delivering cholesterol from lymphoma cells to macrophages.
Mengke Liu, YingYu Dong, Qixiao Guan, JianBiao Wang, Qing Shi, RongGui Lin, Muchen Zhang, Di Fu, Shu Cheng, Pengpeng Xu, Eurydice Angeli, Guilhem Bousquet, Wenguo Cui, Hongjing Dou, Wei‐Li Zhao, Li Wang   +15 more
wiley   +1 more source

Depletion of essential isoprenoids and ER stress induction following acute liver-specific deletion of HMG-CoA reductase

Journal of Lipid Research, 2020
HMG-CoA reductase (Hmgcr) is the rate-limiting enzyme in the mevalonate pathway and is inhibited by statins. In addition to cholesterol, Hmgcr activity is also required for synthesizing nonsterol isoprenoids, such as dolichol, ubiquinone, and ...
Marco De Giorgi, Kelsey E. Jarrett, Jason C. Burton, Alexandria M. Doerfler, Ayrea Hurley, Ang Li, Rachel H. Hsu, Mia Furgurson, Kalyani R. Patel, Jun Han, Christoph H. Borchers, William R. Lagor   +11 more
doaj   +1 more source

Status Epilepticus Alters the Function of Brain‐Derived Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Epilepsy is a neurological disorder characterised by recurrent spontaneous seizures. Approximately 30% of patients are unable to achieve adequate seizure control with available medications, highlighting the need to better understand disease mechanisms and develop improved treatments.
Samantha L. Reed, Yilin Wang, Yangping Li, Guoku Hu, Jingjing Yang, Bing Yao, Andrew Escayg   +6 more
wiley   +1 more source

Anti-HMGCR Autoantibodies in Juvenile Idiopathic Inflammatory Myopathies Identify a Rare but Clinically Important Subset of Patients [PDF]

, 2017
OBJECTIVE: We aimed to establish the prevalence and clinical associations of anti-HMG-CoA-reductase (anti-HMGCR) in a large UK cohort with juvenile myositis. METHODS: There were 381 patients investigated for anti-HMGCR using ELISA.
Simou, S, Wedderburn, LR, Juvenile Dermatomyositis Research Group, Pilkington, C, Jacques, TS, McHugh, NJ, Warrier, K, Betteridge, ZE, Tansley, SL, Wood, M   +9 more
core   +3 more sources

Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Dysregulated lipid metabolism facilitates hepatocellular carcinoma (HCC) development, progression, immunosuppressive tumor microenvironment (TME) formation, and therapeutic resistance. Notably, the patterns of lipid metabolism vary significantly among different types of HCC driven by various etiologies.
Yi Yi, Xi Liu, Xi Zhang, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

Anti-HMGCR myopathy with cardiac involvement

European Heart Journal - Cardiovascular Imaging, 2021
Franz Wegner, Sophie Biedermann, Ole Hudowenz   +2 more
openaire   +2 more sources

The Use of Statins in Parkinson's and Alzheimer's Disease: A 2021–2025 State‐of‐the‐Art Review of Clinical and Preclinical Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Statins, widely prescribed for cardiovascular prevention, have emerged as potential disease‐modifying agents in neurodegenerative disorders due to their pleiotropic effects on cholesterol metabolism, neuroinflammation, oxidative stress, and protein aggregation.
Luigi Maria Chiatto, Lucia Buccarello, Giuseppe Carota, Rocco Salvatore Calabrò, Carmela Rifici, Emanuela Esposito, Alessio Ardizzone, Giuseppe Caruso   +7 more
wiley   +1 more source

Variation in PCSK9 and HMGCR and Risk of Cardiovascular Disease and Diabetes [PDF]

, 2016
Background: Pharmacologic inhibitors of the proprotein convertase subtilisin-kexin type 9 (PCSK9) are in clinical trials for the treatment of coronary artery disease.
Brook, Robert, S. Fazio, Sabatine, Marc S, Catapano, Alberico L., Fazio, Sergio, Giugliano, Robert, R. D. Brook, A.L. Catapano, J. G. Robinson, R. P. Giugliano, Voros, Szilard, S. Voros, Neff, David, Davey Smith, George, M. J. Chapman, Robinson, Jennifer, Chapman, John, Ference, Brian, G. D. Smith, B. A. Ference, D. R. Neff, M. S. Sabatine   +21 more
core   +1 more source

Inhibiting HMGCR represses stemness and metastasis of hepatocellular carcinoma via Hedgehog signaling

Genes and Diseases
Cancer stem cells (CSCs) play a crucial role in tumor initiation, recurrence, metastasis, and drug resistance. However, the current understanding of CSCs in hepatocellular carcinoma (HCC) remains incomplete.
Zhirong Zhang, Jiayao Yang, Rui Liu, Jing Ma, Kai Wang, Xiaojun Wang, Ni Tang   +6 more
doaj   +1 more source