Results 111 to 120 of about 14,518 (216)

Targeting Brain Cholesterol Homeostasis in Alzheimer's Disease: Mechanisms and Therapeutic Perspectives

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Brain cholesterol homeostasis is tightly regulated and largely independent of peripheral cholesterol. This review proposes a unifying framework in which aging, sex, and related biological stressors, including hypercholesterolemia, neurodegeneration, inflammation, and oxidative stress, converge to disrupt cholesterol homeostasis in the brain ...
Myuri Ruthirakuhan, Ameer Y. Taha, Walter Swardfager   +2 more
wiley   +1 more source

A novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) splice variant with an alternative exon 1 potentially encoding an extended N-terminus

, 2012
Background The major rate-limiting enzyme for de novo cholesterol synthesis is 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR).
Marianne K Kringen, Camilla Stormo, Berg, Jens P, Stormo, Camilla, Armin P Piehler, Piehler, Armin P, Jens P Berg, Kringen, Marianne K, Grimholt, Runa M, Runa M Grimholt   +9 more
core   +1 more source

The Potential Therapeutic Applications of Natural Products in the Oxidative Stress-Related MVA Pathway: Focus on HMGCR

Antioxidants
This review explores the therapeutic promise of natural compounds in modulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), a key enzyme in cholesterol synthesis. HMGCR dysregulation is implicated in dyslipidemia, cardiovascular disease, and
Yu-Ning Teng
doaj   +1 more source

HgiAI polymorphism near the HMGCR promoter [PDF]

Nucleic Acids Research, 1990
E, Leitersdorf, K L, Luskey
openaire   +2 more sources

Virtual screening and evaluation of bioactive peptides from Haliotis discus hannai as potential HMGCR inhibitors for hyperlipidemia treatment

Frontiers in Nutrition
IntroductionHyperlipidemia remains a major disease threatening global public health. The morbidity and mortality associated with cardiovascular diseases have been increasing.
Kun Qiao, Lina Liu, Yihui Chen, Qiongmei Huang, Bei Chen, Jingna Wu, Wenmei Huang, Zhiyu Liu   +7 more
doaj   +1 more source

Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis

, 2017
Objective-The cellular demand for cholesterol requires control of its biosynthesis by the mevalonate pathway. Regulation of HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase), a rate-limiting enzyme in this pathway and the target of statins, is a ...
Marlene van den Berg, Elmer Stickel, Martina Moeton, van den Berg, Marlene, Joseph Roitelman, Zelcer, Noam, Gelberg-Etel, Hila, Noam Zelcer, Anke Loregger, Thijn Brummelkamp, Tan, Josephine, Roitelman, Joseph, Raaben, Matthijs, Loregger, Anke, Scheij, Saskia, Brummelkamp, Thijn, Hila Gelberg-Etel, Stickel, Elmer, Saskia Scheij, Josephine Tan, Moeton, Martina, Matthijs Raaben   +21 more
core   +1 more source

Human hydroxymethylglutaryl-coenzyme A reductase (HMGCR) and statin sensitivity

, 2010
331-339While statins, hydroxymethylglutaryl-coenzyme A reductase (HMGCR) inhibitors, are clinically proven to reduce plasma cholesterol levels, a wide variation in inter-individual response to statin therapy has been observed.
Seidle, Heather, Jawaid, Safdar, Gertz, Monica, Couch, Robin D, Corsino, Carlin, Cheung, Jamie   +5 more
core  

Schnyder corneal dystrophy-associated UBIAD1 mutations cause corneal cholesterol accumulation by stabilizing HMG-CoA reductase.

PLoS Genetics, 2019
Schnyder corneal dystrophy (SCD) is a rare genetic eye disease characterized by corneal opacification resulted from deposition of excess free cholesterol. UbiA prenyltransferase domain-containing protein-1 (UBIAD1) is an enzyme catalyzing biosynthesis of
Shi-You Jiang, Jing-Jie Tang, Xu Xiao, Wei Qi, Suqian Wu, Chao Jiang, Jiaxu Hong, Jianjiang Xu, Bao-Liang Song, Jie Luo   +9 more
doaj   +1 more source

Precise identification and tracking of HMGCR-reactive CD4+ T cells in the target tissue of patients with anti-HMGCR immune-mediated necrotising myopathy

Annals of the Rheumatic Diseases
Anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR)-positive immune-mediated necrotising myopathy (IMNM) is characterised by the presence of IgG autoantibodies against HMGCR and a strong association with specific HLA-DR alleles. Although these findings implicate HMGCR-specific CD4+T-cells in the disease's pathogenesis, no such cells have been ...
Eleni Tiniakou, Alex Girgis, Tiara N. Safaei, Jemima Albayda, Brittany Adler, Julie J. Paik, Christopher A. Mecoli, Alison Rebman, Mark J. Soloski, Lisa Christopher-Stine, Kellie N. Smith, Antony Rosen, Andrew Lee Mammen, Erika Darrah   +13 more
openaire   +3 more sources

Causal relationship between lipid-lowering drugs and ovarian cancer, cervical cancer: a drug target mendelian randomization study

BMC Cancer
Background The causal impact of lipid-lowering drugs on ovarian cancer (OC) and cervical cancer (CC) has received considerable attention, but its causal relationship is still a subject of debate.
Jinshuai Li, Zixian Yang, Tao Wang, Mengqi Li, Xiangjian Wu, Xiaoyan Fu, Chunfeng Yang, Yangpu Li, Ximing Wang, Zhiming Lan, Minfang Li, Sheng Chen   +11 more
doaj   +1 more source