Results 101 to 110 of about 14,518 (216)

Anti-HMGCR myopathy mimicking facioscapulohumeral muscular dystrophy

Open Medicine
Abstract Introduction Statin use can lead to various muscle-related issues, including benign creatine kinase (CK) elevations, myalgias, toxic myopathies, rhabdomyolysis, and immune-mediated necrotizing myositis (IMNM), which primarily affects older males.
Braun, Andreas Albert, Atiya, Monika, Göhner, Katja, Hortobagyi, Tibor, Burkhardt, Tobias, Schreiner, Bettina   +5 more
openaire   +3 more sources

Calpain‐4 Knockdown Modulates Cholesterol Metabolism and LXRα Nuclear Localization in Experimental Alcohol‐Related Liver Disease

Alcohol, Clinical and Experimental Research, Volume 50, Issue 6, June 2026.
Calpain‐4 knockdown in alcohol‐related liver disease promotes LXRα nuclear translocation and HMGCR cleavage, enhancing cholesterol efflux via upregulation of ABCA1/ABCG1 and CPT‐1. This mechanism reduces hepatic cholesterol accumulation and microvesicular steatosis without affecting triglycerides or inflammatory markers, identifying calpain‐4 as a ...
Noriko Kitano, Jiang Li, Sam Taborski, Charis‐Marie Vanderpuye, Pooja Muddasani, Sudrishti Chaudhary, Jia‐Jun Liu, Silvia Liu, Juliane I. Beier, Josepmaria Argemi, Ramon Bataller, Gavin E. Arteel   +11 more
wiley   +1 more source

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, Volume 183, Issue 12, Page 3173-3194, June 2026.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source

The NF‐κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Nuclear Factor‐kappa B (NF‐κB) is a master transcriptional regulator orchestrating critical cellular processes, predominantly immunity and inflammation. However, its aberrant constitutive activation has emerged as a unifying pathogenetic hallmark across diverse malignancies, autoimmune disorders, and chronic inflammatory diseases.
Bherouz Pourdad, Arash Pourdad
wiley   +1 more source

Accumulation of HMGCR protein in tissues of Ubiad1^G184R/+ mice.

, 2019
(A) Regulation of HMGCR in mouse embryonic fibroblasts (MEFs) from WT and Ubiad1G184R/+ embryo. MEF cells were isolated and depleted of sterols in medium containing 10% LPDS, 1 μM lovastatin, 50 μM mevalonate for 16 hr, then indicated concentrations of ...
Shi-You Jiang (395689), Chao Jiang (122046), Suqian Wu (3944753), Wei Qi (132539), Jiaxu Hong (768460), Jing-Jie Tang (666252), Bao-Liang Song (666256), Xu Xiao (314389), Jianjiang Xu (647147), Jie Luo (95251)   +9 more
core   +1 more source

Autoimmune anti-HMGCR myopathy: a rare but disabling complication of statin therapy

, 2022
Presentation  An 85-year-old farmer developed disabling progressive proximal limb weakness and dysphagia after 10 years of statin therapy.  Diagnosis  Creatine kinase was elevated, and electromyography demonstrated myopathic abnormalities.
Patrick Moloney (7948142), Y Banaga (14001949), J Cryan (12709166), K O'Rourke (13685812), T Lynch (14001952), I O’Dea (13992867), J Corrigan (13396956)   +6 more
core   +1 more source

Circulating citrate as a mediator in the relationship between HMGCR inhibitors and chronic hepatitis B: a Mendelian randomization study

Scientific Reports
Observational studies have found that HMGCR inhibitors can be used to treat chronic viral hepatitis. In this study, to explore the potential mechanism of HMGCR inhibitors in treating Chronic hepatitis B (CHB), two-sample and two-step Mendelian ...
Lili Zhang, Yuming Li, Ying Li
doaj   +1 more source

Peroxisomal Localization of a Truncated HMG-CoA Reductase under Low Cholesterol Conditions

Biomolecules
3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase, HMGCR) is one of the rate-limiting enzymes in the mevalonate pathway required for cholesterol biosynthesis.
Jianqiu Wang, Markus Kunze, Andrea Villoria-González, Isabelle Weinhofer, Johannes Berger   +4 more
doaj   +1 more source

FTO‐Catalysed Demethylation of LUR1 mRNA Suppresses Macrophage Lipid Accumulation and Aortic Atherosclerosis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Lipid deposition and foam cell formation drive atherogenesis. Lipid uptake regulator 1 (LUR1) and N6‐methyladenosine (m6A) modification play key roles in systemic lipid homeostasis. Bioinformatic analyses revealed a negative correlation between fat mass and obesity‐associated protein (FTO) and LUR1 expression and abundant m6A sites within the ...
Xiang‐Yang Tang, Le Zhou, Shu‐Jun Li, Shao‐Xiang Zhang, Yue‐Ying Yuan, Yun‐Cheng Lv   +5 more
wiley   +1 more source

UBIAD1 (G186R) blocks the ubiquitination and degradation of HMGCR.

, 2019
(A) Effects of human wild-type (WT) UBIAD1 and mutated UBIAD1 (G186R) (equivalent to mouse G184R) on HMGCR protein level. HEK-293 cells stably expressing human (homo sapiens, Hs) WT UBIAD1-TAP and UBIAD1 (G186R)-TAP, respectively, were depleted of ...
Shi-You Jiang (395689), Chao Jiang (122046), Suqian Wu (3944753), Wei Qi (132539), Jiaxu Hong (768460), Jing-Jie Tang (666252), Bao-Liang Song (666256), Xu Xiao (314389), Jianjiang Xu (647147), Jie Luo (95251)   +9 more
core   +1 more source