Results 101 to 110 of about 15,635 (172)

Hmgcr ryšio su acetilcholino sistema charakterizavimas, aiškinanant Drosophila Melanogaster judėjimą. [PDF]

, 2020
Statins are inhibitors of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). This group of drugs is used to lower low-density lipoprotein cholesterol (LDL-C) and is one of the most effective drugs in decreasing the incidence of ...
Vasionis, Lukas,
core  

Causal relationship between lipid-lowering drugs and ovarian cancer, cervical cancer: a drug target mendelian randomization study

BMC Cancer
Background The causal impact of lipid-lowering drugs on ovarian cancer (OC) and cervical cancer (CC) has received considerable attention, but its causal relationship is still a subject of debate.
Jinshuai Li, Zixian Yang, Tao Wang, Mengqi Li, Xiangjian Wu, Xiaoyan Fu, Chunfeng Yang, Yangpu Li, Ximing Wang, Zhiming Lan, Minfang Li, Sheng Chen   +11 more
doaj   +1 more source

The simultaneous targeted Inhibition of ISG15 and HMGCR disrupts cancer stemness through metabolic collapse and induces synthetic lethality in pancreatic ductal adenocarcinoma

Journal of Experimental & Clinical Cancer Research
Precision oncology, a transformative paradigm in cancer therapeutics, leverages molecular profiling to design personalized interventions. Building on our prior discovery of ISG15’s role in pancreatic cancer stem cell (CSC) generation, we identified co ...
Jia Sun, Jia-Mei Wang, Qi Zhang, Wen-Ying Lin, Lin Tang, Shi-Yang Lu, Bai-Qiang Li, Zhen-Xian Du, Hua-Qin Wang   +8 more
doaj   +1 more source

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Aberrant lipid metabolism characterizes the progression of breast cancer. Statins, the canonical agents for modulating this pathway, have been associated with improved overall survival in patients with triple‐negative breast cancer (TNBC). However, their
Guang Li, Yanqiu Zhang, Zheni Xu, Xin Peng, Youzhi Qi, Kun Chen, Xinxin Duan, Xiaoyan Xin, Changchuan Xie, Hongyan Zhu, Zengping Lin, Bing Zhang, Wenqian Wei, Jiaxin Rui, Yaying Wu, Qi Tian, Zhenjie Wang, Tong Su, Yudong Guan   +18 more
core   +1 more source

Pathogénicité des auto-anticorps anti-SRP et anti-HMGCR au cours des myopathies nécrosantes auto-immunes

, 2017
Autoimmune myopathies (AIM), classically called myositis or idiopathic inflammatory myopathies, represent a group of diseases characterized by clinical, histopathologic and biologic properties.
Bergua, Cecile
core  

Reduced <i>HMGCR</i> Expression in Clear Cell Renal Cell Carcinoma Is Associated With Poor Patient Prognosis. [PDF]

Cancer Diagn Progn
Akitaya E, Nakamura Y, Kato S, Kikuta H, Endoh T, Kuramitsu Y, Takahashi Y.   +6 more
europepmc   +1 more source

Pathogenicity of autoantibodies anti-SRP and anti-HMGCR in autoimmune necrotizing myopathies

, 2017
Les myopathies auto-immunes (MAI), classiquement appelées myosites ou myopathies inflammatoires idiopathiques, représentent un groupe de maladies définies par des caractéristiques cliniques, histopathologiques et biologiques. Une des caractéristiques les
Bergua, Cecile
core  

Immunopathogenesis of Immune-Mediated Necrotizing Myopathy: Insights Drawn from Pathological Phenotypes and Mechanistic Elaboration. [PDF]

Biomedicines
Wu X, Qian J, Wang X, Ji N, Li Y, Chen S, Li Q, Liu M, Fang Q.   +8 more
europepmc   +1 more source

SIRT6 Mediates Sterol-Dependent Feedback Regulation of Cholesterol Biosynthetic Genes in Hepatocytes. [PDF]

Biomol Ther (Seoul)
Kim Y, Cho YE, Lim H, Park Y, Hwang S.
europepmc   +1 more source

NUCB2/Nesfatin-1 Couples Cholesterol Biosynthesis to Keratinocyte Migration to Accelerate Re-Epithelialisation in Cutaneous Wound Repair. [PDF]

Wound Repair Regen
Lin J, Zeng L, Wang K, Xu M, Li M.
europepmc   +1 more source