Results 81 to 90 of about 15,635 (172)

HMGCR is differentially expressed in central nervous system metastasis in human breast cancer.

, 2023
Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with ...
Shahan Mamoor
core   +1 more source

HMGCR: a malignancy hub - frontiers in cancer diagnosis and therapy

Frontiers in Oncology
Cholesterol metabolism is significantly activated during most tumor growth. As a key rate-limiting enzyme in cholesterol synthesis, HMG-CoA reductase (HMGCR) affects tumor metabolic reprogramming by upregulating cholesterol metabolism and promotes tumor ...
Yisong Yang, Yiting Liu, Teng Zou, Jiazhuo Liu, Xingzhi Zhou, Ran Tao, Shuangping Liu, Shuangping Liu   +7 more
doaj   +1 more source

GLP‐1R agonist semaglutide protects human forebrain organoids from cholesterol‐induced neurotoxicity

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Dysregulated cholesterol metabolism represents a critical metabolic stressor in the central nervous system, contributing to neuronal injury across multiple neurological conditions, including Alzheimer's disease (AD). While glucagon‐like peptide‐1 receptor (GLP‐1R) agonists show neuroprotective potential, their capacity to directly
Feifei Yu, Jiani Xu, Yibo Hou, Honghui Zheng, Lingyi Guo, Davit Khutsishvili, Cheng Hai, Wenxin Xu, Bailing Chen, Zitian Wang, Shaohua Ma   +10 more
wiley   +1 more source

AMPK‐Mediated Lipid Metabolic Reprogramming in Cancer: From Mechanisms to Targeted Therapies

Cell Biochemistry and Function, Volume 44, Issue 10, October 2026.
ABSTRACT AMP‐activated protein kinase (AMPK), a key regulator of cellular energy metabolism, is activated under conditions of energy stress to restore metabolic homeostasis by promoting catabolic pathways and inhibiting anabolic processes such as lipid synthesis. Multiple key molecules involved in lipid metabolism are regulated by AMPK, and its role in
Yuying Chen, Wen Liu, Bing Luo
wiley   +1 more source

Accumulation of HMGCR protein in tissues of Ubiad1^G184R/+ mice.

, 2019
(A) Regulation of HMGCR in mouse embryonic fibroblasts (MEFs) from WT and Ubiad1G184R/+ embryo. MEF cells were isolated and depleted of sterols in medium containing 10% LPDS, 1 μM lovastatin, 50 μM mevalonate for 16 hr, then indicated concentrations of ...
Shi-You Jiang (395689), Chao Jiang (122046), Suqian Wu (3944753), Wei Qi (132539), Jiaxu Hong (768460), Jing-Jie Tang (666252), Bao-Liang Song (666256), Xu Xiao (314389), Jianjiang Xu (647147), Jie Luo (95251)   +9 more
core   +1 more source

Gallstone formation and hepatobiliary tumour risk: Clinical implications of the bile acid–gut microbiota axis

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
1. Irregular dietary patterns (e.g., late breakfast, reduced meal frequency) upregulate the bai gene cluster by disrupting cholecystokinin (CCK) release rhythms and gut microbiota circadian rhythms, leading to increased production of secondary bile acids, particularly DCA. High‐carbohydrate dietary patterns increase gallstone risk (OR = 1.329).
Rui Li, Yong Zhang, Kaishuang Cai, Shaojun Deng, Chaofeng Tan, Yunjie Li, Wenjin Liang   +6 more
wiley   +1 more source

Inhibiting HMGCR represses stemness and metastasis of hepatocellular carcinoma via Hedgehog signaling

Genes and Diseases
Cancer stem cells (CSCs) play a crucial role in tumor initiation, recurrence, metastasis, and drug resistance. However, the current understanding of CSCs in hepatocellular carcinoma (HCC) remains incomplete.
Zhirong Zhang, Jiayao Yang, Rui Liu, Jing Ma, Kai Wang, Xiaojun Wang, Ni Tang   +6 more
doaj   +1 more source

Glycoproteomic Signatures of IgG Subclass N‐Glycosylation Reveal Molecular Endotypes in Idiopathic Inflammatory Myopathies

MedComm, Volume 7, Issue 10, October 2026.
• EThcD‐sceHCD‐MS/MS and updated PANDA software decode IgG N‐glycosylation in IIMs. • Unsupervised clustering reveals three novel glyco‐endotypes matching clinical phenotypes. • A seven‐glycopeptide model enables robust endotype prediction beyond conventional subtypes.
Tong Wu, Yanhong Li, Yingying Ling, Yinlan Wu, Jing Zhao, Lu Cheng, Chunyu Tan, Yi Zhang, Yong Zhang, Yi Liu   +9 more
wiley   +1 more source

Emerging roles of the metabolic regulator 3-hydroxy-3-methylglutaryl coenzyme-CoA reductase in human cancers: From biology to therapeutics

Genes and Diseases
Tumor cells alter several critical metabolic pathways to satisfy their demands for rapid proliferation and survival. Maladjustment of cholesterol metabolism is present in diverse types of tumor cells.
Wenfang Li, Jianxiong Xu, Yuxuan Long, Han Zhang, Xiaojuan Rong, Zhengding Su   +5 more
doaj   +1 more source

Cholesterol 25‐Hydroxylase Deficiency Provides an Optimal and Durable Protective T Helper 1 Immunity via Interleukin‐12–Interleukin‐2 Axis in BCG‐Vaccinated Mice

MedComm, Volume 7, Issue 10, October 2026.
CH25H deficiency permits optimal dendritic cell activation following BCG exposure, characterized by increased IL‐12p70 production. In vivo, CH25H deficiency promotes enhanced BCG‐mediated protection and sustained IL‐2 producing T cell response. ABSTRACT Bacillus Calmette‐Guérin (BCG) remains the only licensed vaccine for tuberculosis (TB), yet its ...
Hagyu Kim, Eunsol Choi, Kee Woong Kwon, Hong‐Hee Choi, Kyungmin Kim, WeonSeok Jung, Sung Jae Shin   +6 more
wiley   +1 more source