PCSK9 inhibitors - clinical applications.
The enzyme PCSK9 has an important role in regulating low-density lipoprotein (LDL) receptors and concentrations of LDL cholesterol. Inhibiting this enzyme could therefore reduce the incidence of ischaemic heart disease. The monoclonal antibodies alirocumab, evolocumab and bococizumab are directed against PCSK9 and inhibit its activity.
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Sustaining the Promise of PCSK9 Inhibitors: Lessons from Real-World Adherence in China. [PDF]
Nohara A.
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Effectiveness of PCSK9 inhibitors versus statins in type 2 diabetes and dyslipidemia: a propensity-matched study. [PDF]
Wu JY +8 more
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Translating the effect of dual lipid reduction with PCSK9 inhibitors on a mechanical vascular instrumental biomarker in familial hypercholesterolemia subjects. [PDF]
Bosco G +13 more
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PCSK9 inhibitors in the management of hypercholesterolaemia after heart transplantation in the UK, a single centre observational study. [PDF]
Akhtar W +6 more
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Paradoxical LDL-C Increase after Switching from PCSK9 Inhibitors to Inclisiran: A Real-World Case Series. [PDF]
Chua SK, Hung HF, Jong BH, Chen LC.
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Medical and Financial Consequences of Using PCSK9 Inhibitors for Managing Hypercholesterolemia in Saudi Arabia: A Historical Cohort Study. [PDF]
AlRuthia Y +7 more
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Hypercholesterolemia Successfully Treated With Two Different PCSK9 Inhibitors in a Patient With Glycogen Storage Disease IXd: Phosphorylase Kinase Deficiency. [PDF]
Huynh T, Nguyen H, Nguyen M.
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