Results 201 to 210 of about 626,377 (227)
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Third generation PCSK9-inhibitors
European Heart Journal, 2023Ulrich Laufs +2 more
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Expanded Indication for PCSK9 Inhibitors
The Medical Letter on Drugs and TherapeuticsThe FDA has approved changes to the wording of the cardiovascular risk reduction indications for the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors evolocumab (Repatha) and alirocumab (Praluent). Both drugs are now approved to reduce the risk of major adverse cardiovascular events (MACE) in adults at increased risk for these events ...
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PCSK9 inhibitors: clinical evidence and implementation
Nature Reviews Cardiology, 2018The gene encoding PCSK9 was first identified and linked to the phenotype of familial hypercholesterolaemia approximately 15 years ago. Soon after, studies uncovered the role of PCSK9 in the regulation of LDL-receptor recycling and identified loss-of-function variants of PCSK9 that were associated with low circulating levels of LDL cholesterol (LDL-C ...
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Evidence of an anti-inflammatory effect of PCSK9 inhibitors within the human atherosclerotic plaque
Atherosclerosis, 2023Celestino Sardu +2 more
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PCSK9 Inhibitors and Cardiovascular Events
New England Journal of Medicine, 2015Marc S, Sabatine +2 more
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Development of small-molecule PCSK9 inhibitors for the treatment of hypercholesterolemia
Drug Discovery Today, 2022Kishor Mohanan, Shakir Ahamad
exaly
The effect of PCSK9 inhibitors on brain stroke prevention: A systematic review and meta-analysis
Nutrition, Metabolism and Cardiovascular Diseases, 2021exaly
Ocular disorders associated with PCSK9 inhibitors: A pharmacovigilance disproportionality analysis
British Journal of Clinical Pharmacology, 2023Shenyin Zhu, Xiaofang Zhao
exaly