Results 31 to 40 of about 790,730 (234)

CTLA-4 and PD-1 ligand gene expression in epithelial thyroid cancers [PDF]

, 2018
The dysregulation of PD-1 ligands (PD-L1 and PD-L2) and CTLA-4 ligands (CD80 and CD86) represents a tumor strategy to escape the immune surveillance. Here, the expression of PD-L1, PD-L2, CD80 and CD86 was evaluated at mRNA level in 94 patients affected ...
Antonelli, Alessandro, Arcieri, Stefano, Baldini, Enke, Barollo, Susi, Carbotta, Giovanni, Catania, Antonio, Fallahi, Poupak, Mian, Caterina, Monti, Massimo, Palmieri, Andrea, Pironi, Daniele, Sorrenti, Salvatore, Tartaglia, Francesco, Tuccilli, Chiara, Ulisse, Salvatore, Vergine, Massimo   +15 more
core   +3 more sources

Machine and deep learning driven models for the design of heat exchangers with micro-finned tubes

Energy and AI
The design of micro-finned tube heat exchangers is a complex task due to intricate geometry, heat transfer goals, material selection, and manufacturing challenges. Nowadays, mathematical models provide valuable insights, aid in optimization, and allow us
Emad Efatinasab, Nima Irannezhad, Mirco Rampazzo, Andrea Diani   +3 more
doaj   +1 more source

Diagnostic Performance of PD-L1 versus PD-1 Expression in Circulating CD20 Cells in Diffuse Large B-Cell Lymphoma

Antibodies, 2022
This study aimed to investigate PD-L1 and PD-1 expression in circulating CD20+ cells in diffuse larger B-cell lymphoma (DLBCL) and to evaluate the predictive and diagnostic performance of PD-L1 versus PD-1 expression in circulating CD20+ cells in DLBCL ...
Manal Mohamed Saber
doaj   +1 more source

Combination Therapies of Guadecitabine and Immune Checkpoint Inhibitors in a Murine Triple-Negative Breast Cancer Model [PDF]

, 2020
Combination Therapies of Guadecitabine and Immune Checkpoint Inhibitors in a Murine Triple-Negative Breast Cancer Model Jamie-Jean Gilmer, Depts. of Biology and Chemistry, with Dr. Sarah Golding, Dept.
Gilmer, Jamie-Jean
core   +1 more source

Immunotherapy protocols in lung cancer

Cancer Research, Statistics, and Treatment, 2018
Immunotherapy has emerged as a valuable treatment option in many advanced malignancies (especially lung cancer). The PD-1 inhibitors (nivolumab and pembrolizumab) and the PD-L1 inhibitors (durvalumab and atezolizumab) have been approved for use in ...
Nandini Menon, Sharada Mailankody
doaj   +1 more source

Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes. [PDF]

, 2016
Low-dose antithymocyte globulin (ATG) plus pegylated granulocyte colony-stimulating factor (G-CSF) preserves β-cell function for at least 12 months in type 1 diabetes.
Atkinson, Mark A, Brusko, Todd M, Gitelman, Stephen E, Gottlieb, Peter A, Haller, Michael J, Hulme, Maigan A, Mathews, Clayton E, Michels, Aaron W, Perry, Daniel J, Posgai, Amanda L, Schatz, Desmond A, Schultz, Andrew R, Shuster, Jonathan J, Wasserfall, Clive H, Zou, Baiming   +14 more
core   +3 more sources

Heterogeneity‐induced NGF‐NGFR communication inefficiency promotes mitotic spindle disorganization in exhausted T cells through PREX1 suppression to impair the anti‐tumor immunotherapy with PD‐1 mAb in hepatocellular carcinoma

Cancer Medicine
Background The mechanism of decreased T cells infiltrating tumor tissues in hepatocellular carcinoma is poorly understood. Methods Cells were separated from the single‐cell RNA‐sequence dataset of hepatocellular carcinoma patients (GSE149614) for cell ...
Xin Wang, Tongwang Yang, Shangheng Shi, Chuanshen Xu, Feng Wang, Deshu Dai, Ge Guan, Yong Zhang, Shuxian Wang, Jianhong Wang, Bingliang Zhang, Peng Liu, Xiaoshuai Bai, Yan Jin, Xinqiang Li, Cunle Zhu, Dexi Chen, Qingguo Xu, Yuan Guo   +18 more
doaj   +1 more source

A Review of Mechanical Design Approaches for Balanced Robotic Manipulation

Robotics
Robot manipulators are suitable for many industrial tasks, such as assembly and pick-and-place operations. However, high-acceleration motions result in shaking forces and moments to the base, which can cause vibration of the manipulator and instability ...
Yash J. Vyas, Volkert van der Wijk, Silvio Cocuzza   +2 more
doaj   +1 more source

Bioinformatic analysis of PD-1 checkpoint blockade response in influenza infection

BMC Genomic Data, 2022
Background The programmed cell death 1 (PD-1)/PD-1 ligand 1 (PD-L1) signaling pathway is significantly upregulated in influenza virus infection, which impairs the antiviral response.
Huilin Ou, Keda Chen, Linfang Chen, Hongcheng Wu   +3 more
doaj   +1 more source

PD-1/PD-L1 axis in organ fibrosis

Frontiers in Immunology, 2023
Fibrosis is a pathological tissue repair activity in which many myofibroblasts are activated and extracellular matrix are excessively accumulated, leading to the formation of permanent scars and finally organ failure.
Youliang Zhao, Yaqian Qu, Changfu Hao, Wu Yao   +3 more
doaj   +1 more source