Results 171 to 180 of about 255,779 (244)

Synergistic Anticancer Effects of Apatinib and PD-L1 Inhibition in Breast Cancer. [PDF]

J Mammary Gland Biol Neoplasia
Han D, Xu J, Guo C.
europepmc   +1 more source

Intrinsic PPG–ECG Coupling for Accurate and Low‐Power Blood Pressure Monitoring

Advanced Science, EarlyView.
A PPG–ECG coupling strategy for continuous blood pressure monitoring that intrinsically synchronizes signals within a single waveform is demonstrated, minimizing synchronization errors and hardware complexity. This approach halves power consumption while maintaining high accuracy, enabling compact, energy‐efficient wearable devices for personalized ...
Sitong Chen, Hua Luo, Zhentao Yao, Zhou Jiang, Xiaodong Wu, Hanmin Liu   +5 more
wiley   +1 more source

Targeting PD-L1-CMTM6 interactions in myeloid cells triggers PD-L1 degradation and enhances cytotoxic T-cell expansion. [PDF]

J Immunother Cancer
Hsu MA, Liu X, Barham W, Pavelko KD, Harrington SM, Lin C, Hirdler JB, Mao Z, Zhang W, Dellacecca ER, Ashton DS, Sun ND, Lancaster JN, Lucien F, Dong H.   +14 more
europepmc   +1 more source

Trackable Tolerogenic Macrophages Integrate PD‐L1 and Rapamycin Signaling to Suppress Alloimmune Responses in Transplantation

Advanced Science, EarlyView.
We developed a macrophage‐based therapeutic platform, termed trackable tolerogenic macrophages (TTM), for dual‐function immunomodulation and visualization in vivo. TTM cells were engineered to overexpress PD‐L1, incorporate bioorthogonal cell surface tags, and load rapamycin for sustained release.
Yihui Wang, Yuan Song, Yuji Xie, Junmin Zhang, Jing Liu, Wenyuan Wang, Ying Xu, Wenqian Wu, Wuqi Zhou, Qiaofeng Jin, Jing Wang, Yali Yang, Li Zhang, Tang Gao, Mingxing Xie   +14 more
wiley   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Prognostic significance of neuroendocrine differentiation and PD-L1 expression in treatment-naïve prostate cancer. [PDF]

BMC Urol
Tosun I, Sahin O, Bakkaloğlu İG, Şişik NM, Özçelik M.   +4 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Breast cancer microenvironment composition associated with high PD-L1 expression. [PDF]

BMC Cancer
Chekhun V, Lukianova Y, Mushii O, Zadvornyi T, Pavlova A, Burda T, Bazas V, Shepelenko I, Lukianova N.   +8 more
europepmc   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Expression and role of PD-L1 and SOX10 in hepatocellular carcinoma. [PDF]

Transl Cancer Res
So BC, Park HJ, Kim KM, Park HS, Jang KY, Chung MJ, Moon WS, Yang JD, Ahn AR.   +8 more
europepmc   +1 more source