Results 21 to 30 of about 684,663 (243)

Image_1_Differential Engraftment of Parental A20 PD-L1 WT and PD-L1 KO Leukemia Cells in Semiallogeneic Recipients in the Context of PD-L1/PD-1 Interaction and NK Cell-Mediated Hybrid Resistance.tif

, 2022
The contribution of natural killer (NK) cells to tumor rejection in the context of programmed death-ligand 1/programmed death 1 (PD-L1/PD-1) blockade is a matter of intense debate.
Maria-Luisa del Rio (12894632), Rodríguez-Barbosa, José Ignacio, Jose-Antonio Perez-Simon (12894635), Pérez-Simón, José A., Jose-Ignacio Rodriguez-Barbosa (12894638), Río, María Luisa del   +5 more
core   +1 more source

The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology. [PDF]

, 2012
The balance between pro-inflammatory and regulatory immune responses in determining optimal T cell activation is vital for the successful resolution of microbial infections.
Couper, Kevin N, Claser, C, Riley, Eleanor M, Julius Clemence R Hafalla, Eleanor M Riley, Kevin N Couper, de Souza, J Brian, de Souza, J. Brian, Claser Carla, Renia L., Kevin N. Couper (25399), Grau, GE, Hafalla Julius Clemence R., Laurent Renia (63769), Couper, KN, Hafalla, Julius Clemence R, Grau G.E., Couper Kevin N., Grau, Georges Emile, de Souza, JB, Riley Eleanor M., J. Brian de Souza (25406), Claser C., Renia Laurent, Riley E.M., Hafalla J.C.R., Julius Clemence R. Hafalla (185909), de Souza J.B., de Souza J. Brian, Hafalla, JC, Riley, Eleanor M., Couper K.N., Renia, Laurent, Carla Claser, Georges Emile Grau, Carla Claser (185910), Couper, Kevin N., Georges Emile Grau (185911), Renia, L, Riley, EM, J Brian de Souza, Eleanor M. Riley (25407), Grau Georges Emile, Laurent Renia, Claser, Carla   +44 more
core   +1 more source

Supporting data for "Immunophenotyping of anti-PD-L1-treated hepatocellular carcinoma"

, 2023
Hepatocellular carcinoma (HCC) is a deadly disease. The FDA recently approved the first immunotherapy, atezolizumab (anti-PD-L1) plus bevacizumab (anti-VEGF-A), for advanced HCC. Nonetheless, there are still patients not responding.
Fu Wan Sit (11211570)
core   +1 more source

Inhibition of tumor immune escape by blocking PD-1/PD-L1 engagement with dual-targeting molecularly imprinted polymer layer

Cancer Nanotechnology, 2023
Blocking the binding of PD-1/PD-L1 has become an effective strategy in inhibition of tumor immune escape. At present, it mainly depends on the employment of macromolecular antibodies, which target PD-1/PD-L1 protein through binding one of PD-1 or PD-L1 ...
Wenwen Ji, Bei Zhang, Xuetong Sun, Lijuan Ma, Xiangying Zhang, Wenhui Qian, Wenjuan Fu, Jianting Li, Dong Zhu   +8 more
doaj   +1 more source

Establishment of Human PD-1/PD-L1 Blockade Assay Based on Surface Plasmon Resonance (SPR) Biosensor

Bio-Protocol, 2023
Blockade of the programmed cell death protein 1 (PD-1)/PD-ligand 1 (PD-L1) axis is a promising strategy for cancer immunotherapy. Although antibody-based PD-1/PD-L1 inhibitors have shown remarkable results in clinical cancer studies, their inherent ...
Tess Puopolo, huifang Li, Justin Gutkowski, Ang Cai, Navindra Seeram, Hang Ma, Chang Liu   +6 more
doaj   +1 more source

PD-L1 expression on platelets.

, 2021
Whole Blood, a pure platelet pellet, and platelet poor plasma from two patients, one with positive platelet PD-L1 (A) and one with negative platelet PD-L1 (D), was processed through CellSearch® in parallel with PD-L1 staining in the 4th channel.
James M. Rae (7876037), Fang Fang (38179), Erin F. Cobain (11707746), Michael Holinstat (599203), Elizabeth P. Darga (10691311), Daniel F. Hayes (2436220), Steven Kregel (289217), Kelley M. Kidwell (8929835), Christina L. Gersch (11707740), Mark Connelly (9202863), Anoop Gill (11707743), Emily M. Dolce (10691310), Costanza Paoletti (10691308), Dafydd G. Thomas (2388385), Martha E. Brown (10691325), Steven Gross (4533598)   +15 more
core   +1 more source

Overexpression of PD‐L1 causes germ cells to slough from mouse seminiferous tubules via the PD‐L1/PD‐L1 interaction

Journal of Cellular and Molecular Medicine, 2022
AbstractSpermatogenesis is a cyclical process in which different generations of spermatids undergo a series of developmental steps at a fixed time and finally produce spermatids. Here, we report that overexpression of PD‐L1 (B7 homolog1) in the testis causes sperm developmental disorders and infertility in male mice, with severe malformation and ...
Lian Fang, Rui Feng, Weiye Liang, Fang‐Fang Liu, Gan‐lan Bian, Caiyong Yu, Hongmin Guo, Yihui Cao, Mingkai Liu, Jia Zuo, Yinglong Peng, Jie Zhao, Rui‐Xia Sun, Jiajie Shan, Jian Wang   +14 more
openaire   +2 more sources

Posttranslational Modifications in PD-L1 Turnover and Function: From Cradle to Grave

Biomedicines, 2021
Programmed death-ligand 1 (PD-L1) is one of the most classic immune checkpoint molecules. Cancer cells express PD-L1 to inhibit the activity of effector T cells’ cytotoxicity through programmed death 1 (PD-1) engagement in exposure to inflammatory ...
Xinfang Yu, Wei Li, Ken H. Young, Yong Li   +3 more
doaj   +1 more source

PD-L1 expression in lung cancer [PDF]

Journal of Thoracic Disease, 2016
It is with great interest that we read the recent manuscript written by Dr. Yu and colleagues in the Journal of Thoracic Oncology (1). In this manuscript Yu et al. describes different aspects of PD-L1 expression both at the protein and mRNA level in two cohorts of small cell lung cancer (SCLC) patients (1).
Chad, Tang, Joe Y, Chang
openaire   +5 more sources

Accumulation of blood-circulating PD-L1-expressing M-MDSCs and monocytes/macrophages in pretreatment ovarian cancer patients is associated with soluble PD-L1

Journal of Translational Medicine, 2020
Background Previous studies have shown clinical relevance of programmed death-ligand 1 (PD-L1) and soluble PD-L1 (sPD-L1) in human cancers. However, still contradictory results exist.
Karolina Okła, Alicja Rajtak, Arkadiusz Czerwonka, Marcin Bobiński, Anna Wawruszak, Rafał Tarkowski, Wiesława Bednarek, Justyna Szumiło, Jan Kotarski   +8 more
doaj   +1 more source