Results 61 to 70 of about 684,663 (243)

Standardization of PD-L1 immunohistochemistry [PDF]

Modern Pathology, 2022
Sandra Martinez-Morilla, Myrto Moutafi, David L. Rimm   +2 more
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Extracellular vesicles mediate intercellular transfer of PD-L1 and bystander T-cell suppression

Cellular and Molecular Life Sciences
Extracellular vesicles (EVs) carrying programmed death-ligand 1(PD-L1) on their membranes regulate immune responses. While membrane PD-L1 can be exchanged between tumor and immune cells through immune synapse, it remains unclear whether PD-L1 exchange ...
Amar Yeware, Callum Brown, Chih-Chun Chang, Andrea Pennati, Jacques Galipeau   +4 more
doaj   +1 more source

Prognostic perspectives of PD-L1 combined with tumor-infiltrating lymphocytes, Epstein-Barr virus, and microsatellite instability in gastric carcinomas

Diagnostic Pathology, 2020
Background The prognostic potential of PD-L1 is currently unclear in gastric carcinomas, although the immune checkpoint PD-1/PD-L1 inhibitors have produced promising results in clinical trials.
Euno Choi, Mee Soo Chang, Sun-ju Byeon, Heejin Jin, Kyeong Cheon Jung, Haeryoung Kim, Kook Lae Lee, Won Kim, Jin Hyun Park, Ki Hwan Kim, Jin-Soo Kim, In Sil Choi, Dong-Seok Han, Hye Seong Ahn, Seung Chul Heo   +14 more
doaj   +1 more source

Myeloid-derived suppressor cells regulate the immunosuppressive functions of PD-1−PD-L1+ Bregs through PD-L1/PI3K/AKT/NF-κB axis in breast cancer

Cell Death and Disease, 2021
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid cells that are closely related to tumor immune escape, but the mechanism by which MDSCs regulate B cells has not been elucidated.
Min Liu, Feng Wei, Jian Wang, Wenwen Yu, Meng Shen, Ting Liu, Dong Zhang, Yang Wang, Xiubao Ren, Qian Sun   +9 more
doaj   +1 more source

Deubiquitination and Stabilization of PD-L1 by USP21 [PDF]

, 2021
Abstract Background: The immunotherapy for different types of cancers that targeting programmed death protein-1 (PD-1) and programmed death ligand-1 (PD-L1) has highlighted the importance of suppressing specific T cell responses. Recently, several studies have shown that the expression level of PD-L1 in tumor cells is positively correlated with
Shuying Yang, Youqian Wu, Huanhuan Yan, Bing Shan, Dongheng Zhou, Xiaolan Liu, Xinli Mao, Shenkang Zhou, Qingwei Zhao, Hongguang Xia   +9 more
openaire   +2 more sources

PD-L1-expressing CD19⁺ correlated positively with PD-1-expressing CD8⁺ T cells in HIV-1⁺ individuals.

, 2018
(A) Correlation between frequencies of PD-L1 in CD19+ cells and PD-1 in CD4+ T cells and (B) Correlation between frequencies of PD-L1 in CD19+ cells and PD-1 in CD8+ T cells were determined in healthy individuals and in VL-HIV-1+ individuals ...
Marjorie Pion (153357), Adrián Prieto-Sánchez (5703779), Rafael Correa-Rocha (846632), Verónica Astrid Pérez-Fernández (5703776), Santiago Moreno-Guillen (5703782), Jacobo Lopez-Abente (5703770), Carolina Gutierrez (5703773), María-Ángeles Muñoz-Fernández (5703785)   +7 more
core   +1 more source

Western Blot PD-L1 expression after XVir-N-31-anti-PD-L1 infection.pdf

, 2022
PD-L1 expression of HEK cells after XVir-N-31-anti-PD-L1 infection.
Moritz Klawitter (13177230)
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cuproptosis and Disulfidptosis Converge to Empower PD‐L1 Checkpoint Therapy via Cadict‐Induced PD‐L1 Translation

Advanced Science
Immune checkpoint blockade (ICB) has emerged as a cornerstone of cancer therapy, yet its effectiveness remains restricted in PD‐L1‐low malignancies due to insufficient target expression.
Shaoqing Huang, Shiyao Song, Xinhua Zhang, Jialing Gao, Ruihan Pu, Jiatong Dai, Xiaoxue Wu, Lulu Chen, Qinghai Li, Xiaoting Liu, Qi Zhou, Mei Song, Weiling He   +12 more
doaj   +1 more source