Results 11 to 20 of about 1,895,251 (293)

PD-1/PD-L1 blockade accelerates the progression of atherosclerosis in cancer patients

, 2022
PD-1(programed death-1)/PD-L1(programed death-1 ligand) blockade represents a major breakthrough of anti-cancer therapies, however, it may come with increased risk of cardiovascular morbidity, such as myocarditis, acute coronary syndrome, arrhythmias ...
Tse, Gary, Lin, Chen, Dong, Mei, Liu, Tong, Zhang, Nan, Lin, Zerun, Zhong, Lin, Yu, Ting, Wang, Rujian   +8 more
core   +2 more sources

PD-1/PD-L1 inhibitors [PDF]

Current Opinion in Pharmacology, 2015
Tumors may adopt normal physiologic checkpoints for immunomodulation leading to an imbalance between tumor growth and host surveillance. Antibodies targeting the PD-1/PD-L1 checkpoint have shown dynamic and durable tumor regressions, suggesting a rebalancing of the host-tumor interaction.
Joel, Sunshine, Janis M, Taube
openaire   +2 more sources

A snapshot of the PD-1/PD-L1 pathway [PDF]

Journal of Cancer, 2021
Cancer cells can evade the attack from host immune systems via hijacking the regulatory circuits mediated by immune checkpoints. Therefore, reactivating the antitumor immunity by blockade of immune checkpoints is considered as a promising strategy to treat cancer.
Ghosh, Chinmoy, Luong, Gary, Sun, Yue
openaire   +2 more sources

Connecting Binuclear Pd(III) and Mononuclear Pd(IV) Chemistry by Pd–Pd Bond Cleavage [PDF]

Journal of the American Chemical Society, 2012
Oxidation of binuclear Pd(II) complexes with PhICl(2) or PhI(OAc)(2) has previously been shown to afford binuclear Pd(III) complexes featuring a Pd-Pd bond. In contrast, oxidation of binuclear Pd(II) complexes with electrophilic trifluoromethylating ("CF(3)(+)") reagents has been reported to afford mononuclear Pd(IV) complexes.
Powers, DC, Lee, E, Ariafard, A, Sanford, MS, Yates, BF, Canty, AJ, Ritter, T   +6 more
openaire   +4 more sources

Novel nonalloyed thermally stable Pd/Sn and Pd/Sn/Au ohmic contacts for the fabrication of GaAs MESFETs [PDF]

, 2001
GaAs metal-semiconductor field-effect transistors (MESFETs) have been fabricated utilizing thermally stable Pd/Sn and Pd/Sn/Au ohmic contacts for the first time. MESFETs with Pd/Ge ohmic contacts are fabricated for comparison.
McNally, Patrick J., Islam, Md. Shafiqul
core   +2 more sources

HAXPES spectra of Pd

, 2021
This dataset consists of HAXPES spectra at Pd measured at SPring-8 BL46XU, and is a part of HAXPES database (MDR HAXPES DB, https://doi.org/10.48505/nims.3056) as a collection of ...
Industrial Application and Partnership Division, JASRI
core   +1 more source

The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology. [PDF]

, 2012
The balance between pro-inflammatory and regulatory immune responses in determining optimal T cell activation is vital for the successful resolution of microbial infections.
Couper, Kevin N, Claser, C, Riley, Eleanor M, Julius Clemence R Hafalla, Eleanor M Riley, Kevin N Couper, de Souza, J Brian, de Souza, J. Brian, Claser Carla, Renia L., Kevin N. Couper (25399), Grau, GE, Hafalla Julius Clemence R., Laurent Renia (63769), Couper, KN, Hafalla, Julius Clemence R, Grau G.E., Couper Kevin N., Grau, Georges Emile, de Souza, JB, Riley Eleanor M., J. Brian de Souza (25406), Claser C., Renia Laurent, Riley E.M., Hafalla J.C.R., Julius Clemence R. Hafalla (185909), de Souza J.B., de Souza J. Brian, Hafalla, JC, Riley, Eleanor M., Couper K.N., Renia, Laurent, Carla Claser, Georges Emile Grau, Carla Claser (185910), Couper, Kevin N., Georges Emile Grau (185911), Renia, L, Riley, EM, J Brian de Souza, Eleanor M. Riley (25407), Grau Georges Emile, Laurent Renia, Claser, Carla   +44 more
core   +1 more source

DataSheet_1_Resistance to anti-PD-1/anti-PD-L1: galectin-3 inhibition with GB1211 reverses galectin-3-induced blockade of pembrolizumab and atezolizumab binding to PD-1/PD-L1.pdf

, 2023
BackgroundGalectin-3 (Gal-3) is a β-galactoside-binding lectin that is highly expressed within the tumor microenvironment of aggressive cancers and has been suggested to predict a poor response to immune checkpoint therapy with the anti-PD-1 monoclonal ...
James A. Roper, Robert J. Slack, James A. Roper (7135268), Lynda Vuong (14940512), Lynda Vuong, Alison C. Mackinnon (11354112), Joseph Mabbitt, Fredrik R. Zetterberg, Ulf J. Nilsson (831832), Ian D. Holyer (11920195), Joseph Mabbitt (16890483), Fredrik R. Zetterberg (8217516), Ulf J. Nilsson, Anders Pedersen, Ian D. Holyer, Alison C. Mackinnon, Robert J. Slack (1981372), Anders Pedersen (249829)   +17 more
core   +1 more source

PD-1, PD-L1, PD-L2 expression in the chordoma microenvironment [PDF]

Journal of Neuro-Oncology, 2014
Chordomas are rare malignant tumors that are postulated to arise from remnants of the notochord. Currently, the interaction between chordomas and the host immune system is poorly understood. The checkpoint protein, PD-1 is expressed by circulating lymphocytes and is a marker of activation and exhaustion.
Dimitrios, Mathios, Jacob, Ruzevick, Christopher M, Jackson, Haiying, Xu, Sagar R, Shah, Janis M, Taube, Peter C, Burger, Edward F, McCarthy, Alfredo, Quinones-Hinojosa, Drew M, Pardoll, Michael, Lim   +10 more
openaire   +2 more sources

Simultaneous quantifications of four purine derivatives biomarkers in cow milk by SPE HPLC-DAD

Czech Journal of Food Sciences, 2021
In this study, simultaneous quantification of allantoin, uric acid, xanthine, and hypoxanthine in cow milk by solid phase extraction (SPE) and high performance liquid chromatography-diode array detection (HPLC-DAD) method was perform.
Mihaela Vlassa, Filip Miuța, Cătălin Dragomir   +2 more
doaj   +1 more source