Results 41 to 50 of about 716,189 (248)

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Radiographic Evaluation of Defect Fill in Grade II Furcation Employing Guided Tissue Regeneration with Xenograft Alone and Mineral Trioxide Aggregate Combined with Xenograft. Randomized Control Trial

Journal of Pharmacy and Bioallied Sciences
Introduction: Guided tissue regeneration using bone grafts and barrier membranes has shown success, but newer materials like mineral trioxide aggregate (MTA) may enhance outcomes.
Pratiksha Neminath Patil, Yogita Kshirsagar, Sidharth Shrikant Joshi, Swapnil Pise, Neha Deepak Bisht, Varsha Jadhav   +5 more
doaj   +1 more source

Dietary Protein Intake and Peritoneal Protein Losses in Peritoneal Dialysis Patients

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) patients lose protein in their waste dialysate, potentially increasing their risk for malnutrition. We wished to determine whether there was any association between losses and dietary protein intake (DPI). Methods DPI was assessed from 24‐h dietary recall using Nutrics software.
Haalah Shaaker, Andrew Davenport
wiley   +1 more source

A cosine similarity-based method for improving the accuracy of GIS discharge spectrum recognition

Zhejiang dianli
The study of effective feature extraction and optimization algorithms is crucial for improving the accuracy of partial discharge （PD） detection in gas-insulated switchgear （GIS）. To enhance the precision and reliability of GIS partial discharge detection
CHEN Xiaoxin, ZHOU Tonghao, LIU Jiangming, DAI Pengfei, LIU Yanqi, LI Wendong, ZHANG Guanjun   +6 more
doaj   +1 more source

Erratum to: PD-1, PD-L1, PD-L2 expression in the chordoma microenvironment [PDF]

Journal of Neuro-Oncology, 2016
1 Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA 2 Department of Dermatology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA 3 Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA 4 Department of Pathology, The Johns Hopkins ...
Dimitrios, Mathios, Jacob, Ruzevick, Christopher M, Jackson, Haiying, Xu, Sagar R, Shah, Janis M, Taube, Peter C, Burger, Edward F, McCarthy, Alfredo, Quinones-Hinojosa, Drew M, Pardoll, Michael, Lim   +10 more
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Enhancing DC Motor Speed Control Performance Using Heuristic Optimization and Comparative Analysis of Control Methods

Düzce Üniversitesi Bilim ve Teknoloji Dergisi
Direct Current (DC) motors are an important component that converts electrical energy into mechanical energy, used in a wide range of applications from industrial applications to home appliances. DC motor speed control has an important role in industrial
Ali Öztürk, Beytullah Bozali, Nasser Bandar Nasser Al Saremi   +2 more
doaj   +1 more source

PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation [PDF]

Transplant International, 2008
Transplantation of cells, tissues and vascularized solid organs is a successful therapeutic intervention for many end-stage chronic diseases. The combination of co-stimulatory blockade with the delivery of negative signals to T cells through co-inhibitory receptors would provide a robust approach to modulating T-cell receptor signaling and improving ...
Río González, María Luisa del, Buhler, Leo, Gibbons, Carrie, Tian, Jiong, Rodríguez Barbosa, José Ignacio   +4 more
openaire   +4 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source