Results 61 to 70 of about 716,189 (248)
Microorganisms, 2023 The rainbow trout (Oncorhynchus mykiss) is the most important produced species in freshwater within the European Union, usually reared in intensive farming systems.
Lorena Biasini +7 more
doaj +1 more source
PD-1/PD-L pathway and autoimmunity
Autoimmunity, 2005 Programmed cell death 1 (PD-1) was isolated in 1992 by subtractive-hybridization technique, as a molecule whose expression is enhanced by apoptotic stimuli. Since then we have been analyzing the function of PD-1 in the regulation of immune responses. Generation of PD-1 deficient mice, pathophysiological analyses of autoimmune diseases in PD-1 deficient
Taku, Okazaki, Jian, Wang
openaire +2 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Feedback control for deep brain stimulation for motor disorders
Healthcare Technology Letters, 2020 Deep brain stimulation (DBS) is an effective treatment for many people living with Parkinson's disease (PD). Although the primary treatment for PD is based on medications, disease progression eventually leads to inadequate symptom control.
Hugh J. McDermott, Nicholas C. Sinclair
doaj +1 more source
Central Nervous System Xanthoma Disseminatum: Response to 2CdA in an Adolescent
Case Reports in Pediatrics, 2022 Xanthoma disseminatum is a normolipemic non-Langerhans cell histiocytosis characterized by red-brown rubbery papules of the skin which coalesce into plaque-like lesions with symmetric involvement of face, flexor, and intertriginous areas.
Patrick DeMoss +5 more
doaj +1 more source
Potent antitumor antibiotic complex: PD 114,759, PD 115,028, PD 119,707, and PD 119,193.
The Journal of Antibiotics, 1985 Four novel antitumor antibiotics (PD 114,759, PD 115,028, PD 119,707 and PD 119,193) are produced as a complex by a new species of Actinomadura. The proposed name for the culture is Actinomadura verrucosospora subsp. veractimyces ATCC 39363. The antibiotics are extremely bioactive, with MIC values of less than 0.006 ng/ml against several bacteria and ...
J B, Tunac +4 more
openaire +3 more sources
PD-L1/PD-1 Axis in Glioblastoma Multiforme [PDF]
International Journal of Molecular Sciences, 2019 Glioblastoma (GBM) is the most popular primary central nervous system cancer and has an extremely expansive course. Aggressive tumor growth correlates with short median overall survival (OS) oscillating between 14 and 17 months. The survival rate of patients in a three-year follow up oscillates around 10%.
Jakub Litak +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Total Harmonic Distortion Measurement of 13-level FCML Inverter for SPWM and THIPWM Method [PDF]
Journal of Electrical and Electronics Engineering, 2022 One of the main problems for flying capacitor multilevel (FCML) inverter is the higher value of total harmonic distortion (THD) with number of capacitors and switching devices.
BHADRA Ananta Bijoy
doaj
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source