Results 11 to 20 of about 17,680 (157)

Histological diversity of anti-PD1-induced colitis [PDF]

, 2022
Aim. Histological data on anti-PD1-associated colitis are limited, while the colitis subtypes are still not clearly defined and different terms are being used. The aim of the study was to explore the histopathology of anti-PD1-induced colitis.
Papathanasiou, E., Bamias, G., Perdiki, M., Michopoulos, S., Sotiropoulou, M., Sakellariou, S., Zampeli, E., Delladetsima, I.   +7 more
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PD1 signal transduction pathways in T cells [PDF]

, 2017
The use of immune checkpoint inhibitors for the treatment of cancer is revolutionizing oncology. Amongst these therapeutic agents, antibodies that block PD-L1/PD1 interactions between cancer cells and T cells are demonstrating high efficacies and low ...
Arasanz, H, Ibanez-Vea, M, Kochan, G, Kochan, Grazyna, Gato Cañas, María, Zuazo, M, Escors, D, Ibañez Vea, María, Breckpot, K, Breckpot, Karine, Arasanz Esteban, Hugo, Escors Murugarren, David, Gato-Canas, M, Zuazo Ibarra, Miren   +13 more
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Predicting a Stable Dimeric Form of the PD1-PDL1 Complex: Implications for Understanding the PD1 Activation Mechanism

The activation of T cells is typically accompanied by inhibitory mechanisms within which the programmed cell death (PD1) receptor stands out. Upon binding the ligands PDL1 and PDL2, PD1 drives T cells to an unresponsive state called exhaustion ...
Luis F. Ponce (2795155), Daniel P. Ramírez-Echemendia (16413362), Kalet León (11073285), Pedro A. Valiente (1522723)   +3 more
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Tumor CD155 expression is associated with resistance to anti-PD1 immunotherapy in metastatic melanoma [PDF]

, 2020
Purpose: Resistance to anti-PD1 based immune checkpoint blockade (ICB) remains a problem for the treatment of metastatic melanoma. Tumor cells as well as host myeloid cells can express the immune checkpoint ligand CD155 to regulate immune cell function ...
Massi, Daniela, Kuchel, A, Eastgate, M, Leduc, C, Menzies, Alexander M., Pearson, SA, McDonald, E, Bald, Tobias, Johnston, RL, Li, XY, Scolyer, RA, Mandala, Mario, Smyth, MJ, Li, Xian-Yang, Dougall, William C., Eastgate, Melissa, Mandala, M, Ascierto, Paolo A., Waddell, N, Kuchel, Anna, Lepletier, Ailin, Long, Georgina V., Dougall, WC, Stagg, J, Teng, Michele W. L., Routy, B, Wilmott, James S., Johnston, Rebecca L., O'Donnell, Jake S., Ascierto, PA, Wilmott, JS, Ahern, E, Madore, Jason, Madore, J, Mallardo, Domenico, Teng, MWL, Mallardo, D, Scolyer, Richard A., Menzies, AM, Ahern, Elizabeth, Long, GV, Leduc, Charles, Massi, D, Waddell, Nicola, Routy, Bertrand, Bald, T, Lepletier, A, Stagg, John, Merelli, B, McDonald, Elizabeth, Smyth, Mark J., O'Donnell, JS, Pearson, Sally-Ann, Merelli, Barbara, Massi, D.   +54 more
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Functional and molecular characterization of PD1+ tumor-infiltrating lymphocytes from lung cancer patients. [PDF]

, 2022
Antibody-mediated cancer immunotherapy targets inhibitory surface molecules, such as PD1, PD-L1, and CTLA-4, aiming to re-invigorate dysfunctional T cells.
Müller, Stefan, Berezowska, Sabina, Carotta, Sebastian, Marti, Thomas M, Hegedüs, Belazs, Wang, Limei, Kocher, Gregor J, Sommergruber, Wolfgang, Schmid, Ralph A, Hall, Sean R R, Lipp, Jesse J, Dorn, Patrick, Pearson, Mark A, Souabni, Abdallah, Yang, Haitang, Yao, Feng, Harrer, Nathalie, Limei Wang, Haitang Yang, Stefan Müller, Jesse J. Lipp, Thomas M. Marti, Ralph A. Schmid, Sebastian Carotta, Wolfgang Sommergruber, Belazs Hegedüs, Sean R.R. Hall, Feng Yao, Abdallah Souabni, Mark A. Pearson, Patrick Dorn, Greg J. Kocher, Nathalie Harrer, Sabina Berezowska   +33 more
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Progress report no. 10 AAF contract W-33-038-ac-21100 : period 10 : 1 January, 1950 to 1 March, 1950.

, 1948
http://deepblue.lib.umich.edu/bitstream/2027.42/7159/5/bad5734.0010.001.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/7159/4/bad5734.0010.001 ...

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Correlations between LAG-3, PD1 and LAG-3+PD1+ expressing CD4 T cells and cardiac function.

, 2018
Correlations between LAG-3, PD1 and LAG-3+PD1+ expressing CD4 T cells and cardiac function.
Nagalingeswaran Kumarasamy (36007), R. Vignesh (5917070), Savita Pahwa (111433), Bagavathi Kausalya (5917067), Shanmugam Saravanan (848685), Li Pan (49390), Syed Iqbal (5917073), Kailapuri G. Murugavel (5917076), Sunil S. Solomon (771410), Suresh Pallikkuth (430427), Rajendra Pahwa (111415), Selvamuthu Poongulali (5780645)   +11 more
core   +1 more source

Efficacy and safety of anti-PD1 monotherapy or in combination with ipilimumab after BRAF/MEK inhibitors in patients with BRAF mutant metastatic melanoma [PDF]

, 2022
BACKGROUND: Patients with V600BRAF mutant metastatic melanoma have higher rates of progression-free survival (PFS) and overall survival (OS) with first-line anti-PD1 (PD1]+anti-CTLA-4 (IPI) versus PD1. Whether this is also true after BRAF/MEKi therapy is
Lo, Serigne, Lo, Serigne; https://orcid.org/, Michielin, O., Lebbe, C., Johnson, Douglas B, Dimitriou, F., Menzies, Alexander, Ascierto, P.A., Trojanello, C., Dimitriou, Florentia, Michielin, Olivier, Zimmer, L., Trojanello, Claudia, Long, Georgina, Zakria, D., Pires da Silva, Ines; https://orcid.org/, Ascierto, Paolo Antonio, Carlino, M., Mangana, Johanna, Lebbe, Celeste, Gerard, C., Allayous, C., Ahmed, T., Mangana, J., Zakria, Danny, Pires da Silva, I., Carlino, Matteo, Johnson, D.B., Lo, S., Allayous, Clara, Gerard, Camille, Long, G., Zimmer, Lisa, Pires da Silva, Ines, Ahmed, Tasnia, Ascierto, Paolo Antonio; https://orcid.org/, Menzies, A., Paolo Antonio Ascierto, Alexander Menzies, Tasnia Ahmed, Danny Zakria, Serigne Lo, Clara Allayous, Georgina Long, Ines Pires da Silva, Celeste Lebbe, Claudia Trojanello, Camille Gerard, Lisa Zimmer, Douglas B Johnson, Johanna Mangana, Florentia Dimitriou, Olivier Michielin, Matteo Carlino   +53 more
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Correlations between LAG-3, PD1 and LAG-3+PD1+ expressing CD8 T cells and cardiac function.

, 2018
Correlations between LAG-3, PD1 and LAG-3+PD1+ expressing CD8 T cells and cardiac function.
Nagalingeswaran Kumarasamy (36007), R. Vignesh (5917070), Savita Pahwa (111433), Bagavathi Kausalya (5917067), Shanmugam Saravanan (848685), Li Pan (49390), Syed Iqbal (5917073), Kailapuri G. Murugavel (5917076), Sunil S. Solomon (771410), Suresh Pallikkuth (430427), Rajendra Pahwa (111415), Selvamuthu Poongulali (5780645)   +11 more
core   +1 more source

A threshold level of intratumor CD8⁺ T-cell PD1 expression dictates therapeutic response to anti-PD1

, 2015
Despite successes, thus far, a significant proportion of the patients treated with anti-PD1 antibodies have failed to respond. We use mouse tumor models of anti-PD1 sensitivity and resistance and flow cytometry to assess tumor-infiltrating immune cells ...
Young, Arabella, Enot, David, Ngiow, Shin Foong, Yamazaki, Takahiro, Zitvogel, Laurence, Smyth, Mark J., Jacquelot, Nicolas   +6 more
core   +1 more source