Results 21 to 30 of about 13,488 (162)

Functional characterization of PD1+TIM3+ tumor-infiltrating T cells in DLBCL and effects of PD1 or TIM3 blockade

, 2021
International audienceIn diffuse large B-cell lymphoma (DLBCL), tumor-infiltrating T lymphocytes (TILs) are involved in therapeutic responses. However, tumor-specific TILs can be dysfunctional, with impaired effector functions.
Foucher, Etienne, Le Gallou, Simon, Launay, Vincent, Fest, Thierry, Pangault, Céline, Le, Kieu-Suong, Roussel, Mikaël, Granier, Clémence, Xerri, Luc, Tartour, Eric, Olive, Daniel, Lamy, Thierry, Llamas Gutierrez, Francisco   +12 more
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Correlations between LAG-3, PD1 and LAG-3+PD1+ expressing CD8 T cells and cardiac function.

, 2018
Correlations between LAG-3, PD1 and LAG-3+PD1+ expressing CD8 T cells and cardiac function.
Nagalingeswaran Kumarasamy (36007), R. Vignesh (5917070), Savita Pahwa (111433), Bagavathi Kausalya (5917067), Shanmugam Saravanan (848685), Li Pan (49390), Syed Iqbal (5917073), Kailapuri G. Murugavel (5917076), Sunil S. Solomon (771410), Suresh Pallikkuth (430427), Rajendra Pahwa (111415), Selvamuthu Poongulali (5780645)   +11 more
core   +1 more source

Correlations between LAG-3, PD1 and LAG-3+PD1+ expressing CD4 T cells and cardiac function.

, 2018
Correlations between LAG-3, PD1 and LAG-3+PD1+ expressing CD4 T cells and cardiac function.
Nagalingeswaran Kumarasamy (36007), R. Vignesh (5917070), Savita Pahwa (111433), Bagavathi Kausalya (5917067), Shanmugam Saravanan (848685), Li Pan (49390), Syed Iqbal (5917073), Kailapuri G. Murugavel (5917076), Sunil S. Solomon (771410), Suresh Pallikkuth (430427), Rajendra Pahwa (111415), Selvamuthu Poongulali (5780645)   +11 more
core   +1 more source

Tumor CD155 expression is associated with resistance to anti-PD1 immunotherapy in metastatic melanoma

, 2020
Purpose: Resistance to anti-PD1 based immune checkpoint blockade (ICB) remains a problem for the treatment of metastatic melanoma. Tumor cells as well as host myeloid cells can express the immune checkpoint ligand CD155 to regulate immune cell function ...
Massi, Daniela, Kuchel, A, Eastgate, M, Leduc, C, Menzies, Alexander M., Pearson, SA, McDonald, E, Bald, Tobias, Johnston, RL, Li, XY, Scolyer, RA, Mandala, Mario, Smyth, MJ, Li, Xian-Yang, Dougall, William C., Eastgate, Melissa, Mandala, M, Ascierto, Paolo A., Waddell, N, Kuchel, Anna, Lepletier, Ailin, Long, Georgina V., Dougall, WC, Stagg, J, Teng, Michele W. L., Routy, B, Wilmott, James S., Johnston, Rebecca L., O'Donnell, Jake S., Ascierto, PA, Wilmott, JS, Ahern, E, Madore, Jason, Madore, J, Mallardo, Domenico, Teng, MWL, Mallardo, D, Scolyer, Richard A., Menzies, AM, Ahern, Elizabeth, Long, GV, Leduc, Charles, Massi, D, Waddell, Nicola, Routy, Bertrand, Bald, T, Lepletier, A, Stagg, John, Merelli, B, McDonald, Elizabeth, Smyth, Mark J., O'Donnell, JS, Pearson, Sally-Ann, Merelli, Barbara   +53 more
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Efficacy of anti-PD1 re-treatment in patients with Hodgkin lymphoma who relapsed after anti-PD1 discontinuation

, 2020
International audiencePatients with relapsed/refractory Hodgkin lymphoma (R/R HL) experience high response rates upon anti-PD1 therapy. In these patients, there is limited data about the optimal duration of treatment and the risk of relapse after anti ...
Roch Houot, Dercle, Laurent, Guillaume Manson, Florence Poizeau, Houot, Roch, Herbaux, Charles, Pauline Brice, Bouabdallah, Kamal, Antier, Chloé, Charles Herbaux, Laurent Dercle, Chloé Antier, Brice, Pauline, Poizeau, Florence, Manson, Guillaume, Kamal Bouabdallah   +15 more
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DataSheet_1_Bv8 Blockade Sensitizes Anti-PD1 Therapy Resistant Tumors.pdf

, 2022
Myeloid-derived suppressor cells (MDSCs) are known to promote tumor growth in part by their immunosuppressive activities and their angiogenesis support.
Avital Vorontsova (13010106), Abhilash Deo (13010118), Jozafina Haj-Shomaly (13010115), Bar Manobla (13010124), Sapir Levin (13010112), Yuval Shaked (37384), Michael Timaner (13010109), Rotem Menachem (13010121), Tim J. Cooper (13010127), Madeleine Benguigui (13010103), Ziv Raviv (361914)   +10 more
core   +1 more source

Materiale Textkulturen. Konzepte-Materialien-Praktiken [PDF]

, 2015
How does one define and explore the “material presence of the written in non-typographical cultures?” The interdisciplinary and collaborative essays in this handbook present theoretical principles, describe text-bearing materials and objects, and ...
Sauer, Rebecca, Ott, Michael R., Meier, Thomas   +2 more
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Abstract 5603: Melanoma PD1 expression is upregulated by MAPK inhibitors leading to an immune-independent synergism with anti-PD1 antibodies

, 2017
Background Antibodies blocking the inhibitory checkpoint PD1, expressed by T lymphocytes, and kinase inhibitors of BRAF and MEK (MAPKi) are mainstays of current treatment for patients with metastatic melanoma.
Lidia Giraudo, Arianna Floris, Martina Sanlorenzo, Marco Macagno, Pietro Quaglino, Maria Teresa Fierro, Fabrizio Carnevale-Schianca, Mauro Novelli, Loretta Gammaitoni, Igor Vujic, Chiara Donini, Dario Sangiolo, Massimo Aglietta, Silvia Giordano   +13 more
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A threshold level of intratumor CD8⁺ T-cell PD1 expression dictates therapeutic response to anti-PD1

, 2015
Despite successes, thus far, a significant proportion of the patients treated with anti-PD1 antibodies have failed to respond. We use mouse tumor models of anti-PD1 sensitivity and resistance and flow cytometry to assess tumor-infiltrating immune cells ...
Young, Arabella, Enot, David, Ngiow, Shin Foong, Yamazaki, Takahiro, Zitvogel, Laurence, Smyth, Mark J., Jacquelot, Nicolas   +6 more
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nathanson-lab/PD1-WES: Init

, 2018
<p>Initial release of code for publication</p ...
nathanson-lab
core   +1 more source