Results 141 to 150 of about 2,849 (260)

Noninvasive Characterization of Tumor Heterogeneity in HNSCC: From Clinical Utility to Biological Correlates

Advanced Science, EarlyView.
This study establishes a CT‐based radiomics framework to quantify intratumoral heterogeneity (ITH) in HNSCC. Using unsupervised clustering, tumor ROIs and VOIs are analyzed to calculate 2D/3D ITH scores. The score shows strong predictive value for prognosis and immunotherapy response, and is associated with tumor metabolism and immune microenvironment,
Xinwei Chen, Rui Liu, Yuan Zhou, Yin Xiao, Chengmin Feng, Lin Chen, Yanshi Li, Mengna Wang, Zhaobo Cheng, Yuxi Luo, Long Liu, Lijing Niu, Yue Xiang, Juan Peng, Guohua Hu, Min Pan   +15 more
wiley   +1 more source

Plasma expression of long non-coding RNA <i>GAS5</i> and its prognostic significance in newly diagnosed multiple myeloma. [PDF]

Front Oncol
Pravdic Divac A, Tosic N, Cvetkovic Z, Radulovic M, Karan-Djurasevic T, Tomic A, Marjanovic I, Stanisavljevic N, Zukic B, Markovic O.   +9 more
europepmc   +1 more source

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

Peripheral Immune Remodeling After Spinal Cord Injury: Marked by Expansion of CD38⁺, CTLA-4⁺, and PD-1⁺ T and NK Cells. [PDF]

Neurol Neuroimmunol Neuroinflamm
Veeningen N, Añé-Kourí AL, Pues A, Rubio S, Fraussen J, Ioannou C, Martens DS, van Laake-Geelen CCM, Deckers J, Cornips EMJ, Bamps S, Gysemberg G, Van Broeckhoven J, Hellings N, Slaets H.   +14 more
europepmc   +1 more source

Evaluation of the freezing Point of Zinc for Pt/Pd Thermocouple Calibration

SICE Annual Conference Program and Abstracts, 2003
Narushima, Hirokazu, Ogura, Hideki, Izuchi, Masaya, Arai, Masaru   +3 more
openaire   +1 more source

Artificial Intelligence‐Based Body Composition Analysis Reveals Sex‐Specific Prognostic Markers and Their Clinical Value in Gastric Cancer: A Multicenter Study

Advanced Science, EarlyView.
This study applied AI to quantify multidimensional body composition from CT images in gastric cancer and healthy controls. Distinct sex‐specific patterns and disease‐related alterations were identified and were associated with survival. Higher muscle and fat measures were linked to improved outcomes.
Tianxiang Li, Tingting Liu, Qian Yang, Zhiqing Zhang, Xiaofang Guo, Xiang Wang, Yihan Zhang, Limin Ge, Yu Su, Wenjun Wu, Weihua Guo, Zheng Wang, Lian Yang, Yanfeng Niu   +13 more
wiley   +1 more source

The <i>in vitro</i> anticoagulant effect of abelacimab in healthy children. [PDF]

Res Pract Thromb Haemost
Letunica N, Collett S, Karlaftis V, Khder Y, Freedholm D, Monagle P, Attard C.   +6 more
europepmc   +1 more source

Long‐Term Ambient Benzene Exposure and Brain Disorders Among Urban Adults: Effect Modification by Genetic Susceptibility and Potential Mediation by Plasma Proteins

Advanced Science, EarlyView.
Low‐level ambient benzene exposure is associated with increased risks of multiple brain disorders in urban adults. Genetic susceptibility modifies these associations, while plasma proteomics points to potential biological pathways linking benzene exposure to adverse brain health.
Jianhui Guo, Xia Zhong, Petros Koutrakis, Carolina L. Zilli Vieira, Feifei Si, Yaqi Wang, Xinyao Lian, Yi Fan, Zhaokun Wang, Shaodan Huang, Jing Li   +10 more
wiley   +1 more source

Association between Plasma P-tau217 and Alzheimer's Copathology and Cognitive Decline in Parkinson's Disease. [PDF]

Ann Neurol
Tropea TF, Stevenson PA, Flitter M, Meehan D, Morris A, Lu M, Iaccarino L, Collins EC, Hodsdon ME, Irwin D, Spindler M, Deik A, Dahodwala N, Cousins KAQ, Wolk DA, Shaw L, Weintraub D, Lee EB, Chen-Plotkin A, Mintun M, Siderowf A.   +20 more
europepmc   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source