Results 141 to 150 of about 9,938 (266)

A 3D gut-brain-vascular platform for bidirectional crosstalk in gut-neuropathogenesis. [PDF]

Nat Commun
Tran M, Jeong HW, An M, Been C, Jamsranjav A, Kwak SM, Lee LP, Cho H.   +7 more
europepmc   +1 more source

NQO1‐Mediated Anoikis Resistance and Immune Evasion Define a High‐Risk Multi‐Omic Subtype for Precision Management of T1 High‐Grade Bladder Cancer

Advanced Science, EarlyView.
Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo, Chunru Xu, Shufan Fu, Qiang Cheng, Juan Li, Linkuo Shang, Gaojie Li, Yang Yang, Ying Wang, Yanqing Gong, Shengwei Xiong, Jian Fan, Changwei Yuan, Mei Zhang, Yifan Zuo, Elena Papaleo, Yue Shi, Yuan Liang, Xuesong Li, Hongzhao Li, Weimin Ci   +20 more
wiley   +1 more source

Plasma IL-6, IL-8 and IL-10 as predictors of response to PD-1 blockade immunochemotherapy in advanced gastric cancer. [PDF]

Clin Exp Med
Yang F, Yao J, Tong X, Luo X, Liu Q, Zhu W.   +5 more
europepmc   +1 more source

G4‐Ligand‐Directed PROTACs Unveil DR1 as a Novel Ligand‐Co‐Binding G4‐Protein and Reshape G4‐Dependent Transcription

Advanced Science, EarlyView.
G4‐binding proteins (G4BPs) that specifically co‐bind G4s in the presence of small‐molecule ligands represent a critical but unexplored class of proteins. We introduce G4‐Ligand‐Directed PROTACs (G4L‐TACs), a chemical platform that couples G4 ligands (PDS) to E3 recruiters to selectively degrade these ligand‐co‐binding G4BPs.
Mao‐Lin Li, Shu‐Min Xu, Xin‐Chen Jiang, Le‐Tian Dai, Yu‐Tao Hu, Kai‐Bo Wang, Jia‐Heng Tan, Zhi‐Shu Huang, Shuo‐Bin Chen   +8 more
wiley   +1 more source

DCTPP1 drives immunosuppression and poor prognosis in breast cancer by promoting M2 macrophage polarization. [PDF]

Sci Rep
Chi J, Liu W, Zhai Z, Wang L, Wang X, Ma Z.   +5 more
europepmc   +1 more source

Sustainable Materials Design With Multi‐Modal Artificial Intelligence

Advanced Science, EarlyView.
Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu, Tianshuo Wei, Yan Ge, Bo Peng, Yue Li, Maolin Wang, Peng Wen, Chao Yang, Ye Wei   +8 more
wiley   +1 more source

Assessment of Mitochondrial DNA Copy Number in Progressive Supranuclear Palsy Patients: Evidence From a Pilot Study. [PDF]

Eur J Neurol
Citrigno L, Cerantonio A, Gagliardi M, Procopio R, Felicetti A, Aureli A, Morelli M, Annesi G.   +7 more
europepmc   +1 more source

MGDP: Mastering a Generalized Depth Perception Model for Quadruped Locomotion

Advanced Science, EarlyView.
ABSTRACT Perception‐based Deep Reinforcement Learning (DRL) controllers demonstrate impressive performance on challenging terrains. However, existing controllers still face core limitations, struggling to achieve both terrain generality and platform transferability, and are constrained by high computational overhead and sensitivity to sensor noise.
Yinzhao Dong, Ji Ma, Yidan Lu, Jiahui Zhang, Wanyue Li, Yeke Chen, Teng Zhang, Xuechao Chen, Zhangguo Yu, Peng Lu   +9 more
wiley   +1 more source

LC-MS/MS-Based Determination of Ambroxol in Human Plasma and Cerebrospinal Fluid: Validation and Applicability in a Phase II Study on GBA-Associated Parkinson's Disease Patients. [PDF]

Int J Mol Sci
Franco V, Palmisani M, Colucci F, De Micco R, Aloisio S, Cazzaniga F, Cerri S, Crema F, Dattrino F, Garavaglia B, Gastaldi M, Mitrotti P, Moda F, Rota P, Stiuso R, Tassorelli C, Eleopra R, Tessitore A, Valente EM, Avenali M, Cilia R.   +20 more
europepmc   +1 more source

Enhanced Energy Transfer from a Metal–Organic Framework to a Highly Confined Organic Phosphorescent Dye

Advanced Science, EarlyView.
A phosphorescent dye was designed to fit in a hand‐to‐glove fashion into the 1D‐pore channels of MIL‐68(In). We synthesized MIL‐68(In) as powder and thin films, loaded the dye into the pores with controlled packing, and found that the phosphorescence and quantum yield are enhanced.
Bahram Hosseini Monjezi, Thomas Kasper, Gloria Hong, Changfeng Si, Robert Oestreich, Oliver Weingart, Peter G. Weidler, Christof Wöll, Eli Zysman‐Colman, Christoph Janiak, Stefan Bräse, Klaus Müller‐Buschbaum, Alexander Knebel   +12 more
wiley   +1 more source