Results 171 to 180 of about 9,938 (266)

Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound

Advanced Science, EarlyView.
Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García, José A. Pineda‐Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo‐Ortiz, Megan Carrillo, Alejandro Reinares‐Sebastian, Víctor Medina‐Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa   +11 more
wiley   +1 more source

Liraglutide Modulates Zinc Release and Improves Mitochondrial Function in Insulin-Resistant Senescent Cardiomyocytes. [PDF]

Cardiovasc Toxicol
Hosseinpourshirazi F, Mendes UD, Aksoy ZB, Aydos D, Sözer M, Aljaser L, Gundogdu M, Sık S, Tuncay E, Turan B, Olgar Y.   +10 more
europepmc   +1 more source

Localizable Fluorescent Metal Ion Indicators With Tunable Colors

Advanced Science, EarlyView.
A modular platform enables the generation of fluorescent metal ion indicators with tunable emission colors and precise subcellular localization. Conjugation to self‐labeling proteins yields bright, color‐tunable potassium probes that permit wash‐free live‐cell imaging, revealing dynamic potassium efflux in stimulated neurons.
Ming‐Ming Wang, De‐en Sun, Klara Gries, Kai Johnsson   +3 more
wiley   +1 more source

An eight-year follow-up of the CMSAR: assessing how the new MDS criteria and biomarkers impact diagnostic accuracy. [PDF]

NPJ Parkinsons Dis
Soriano AP, Painous C, Fernandez M, Pérez J, Ruiz-Garcia R, Naranjo L, Camara A, Aldecoa I, Molina L, Compta Y, Muñoz E, Martí MJ, CMSAR CONSORTIUM.   +12 more
europepmc   +1 more source

Wireless, Adaptable and Fully Implantable Battery‐powered Devices for Optical Stimulation of the Spinal Cord in Small Rodents

Advanced Science, EarlyView.
Current technologies for spinal cord optogenetic stimulation rely on external power sources and face reliability constraints in freely behaving animals. Here, a fully implantable, battery‐powered optoelectronic device is introduced, enabling operation in any selected environment with wireless recharging for months‐long stimulation.
Shahriar Shalileh, Adan Moallemi, Elham Mohseni Vadeghani, Samuel Tretjakov, Brianna Tsuyuki, Alexander Golab, Benjamin Rever, Wolfram Tetzlaff, Dena Shahriari   +8 more
wiley   +1 more source

Ultrasensitive Protein Aggregate Quantification Assays for Neurodegenerative Diseases on the Simoa Platform. [PDF]

Anal Chem
Böken D, Xia Z, Lam JYL, Fertan E, Wu Y, English EA, Konc J, Layburn F, Bernardes GJL, Zetterberg H, Cheetham MR, Klenerman D.   +11 more
europepmc   +1 more source

Calibration of PD-calibrators.

, 1998
openaire   +1 more source

Wavefront Line‐Scan Imaging Via a Single‐Pixel Detector

Advanced Science, EarlyView.
We propose and demonstrate a wavefront line‐scan imaging paradigm that integrates 1D spatial light modulation with single‐pixel detection. Benefiting from 1D modulation, not only is the imaging speed improved, but also the storage of modulation patterns is reduced by several orders of magnitude.
Nuo Liu, Aiping Zhai, Tingting Zheng, Wenjing Zhao, Dong Wang   +4 more
wiley   +1 more source

Soluble immune checkpoints reflect immune activation and treatment response in high-risk systemic sclerosis patients treated with plasma exchange. [PDF]

J Transl Autoimmun
Potjewijd J, Tobal R, van Doorn DPC, Schurgers LJ, Heeringa P, Damoiseaux JGMC, van Paassen P.   +6 more
europepmc   +1 more source