Results 31 to 40 of about 291,222 (247)

Molecular effect of an OPTN common variant associated to Paget's disease of bone. [PDF]

PLoS ONE, 2018
Paget's disease of bone (PDB) is a chronic bone disorder and although genetic factors appear to play an important role in its pathogenesis, to date PDB causing mutations were identified only in the Sequestosome 1 (SQSTM1) gene at the PDB3 locus.
Iris A L Silva, Natércia Conceição, Édith Gagnon, Jacques P Brown, M Leonor Cancela, Laëtitia Michou   +5 more
doaj   +1 more source

Paget’s disease: a review of the epidemiology, etiology, genetics, and treatment

Frontiers in Genetics, 2023
Paget’s disease of bone (PDB) is the second most prevalent metabolic bone disorder worldwide, with a prevalence rate of 1.5%–8.3%. It is characterized by localized areas of accelerated, disorganized, and excessive bone production and turnover. Typically,
Babajan Banaganapalli, Babajan Banaganapalli, Ibrahim Fallatah, Fai Alsubhi, Preetha Jayasheela Shetty, Zuhier Awan, Ramu Elango, Ramu Elango, Noor Ahmad Shaik, Noor Ahmad Shaik   +9 more
doaj   +1 more source

Paget's disease of bone presenting with multiple cranial nerve palsies: A case report

Radiology Case Reports, 2022
Paget's disease of bone (PDB) is a progressive monostotic or polyostotic osteopathy with unknown cause. It is associated with the involvement of the nervous system. The cranial nerves, spinal roots, cauda equina, spinal cord, and brain can be affected in
M. Hamid, MD, F. Touarsa, MD, A. Satte, MD, A. Bourazza, MD   +3 more
doaj   +1 more source

The PDB data uniformity project [PDF]

Nucleic Acids Research, 2001
The Protein Data Bank (PDB; http://www.rcsb.org/pdb/) is the single worldwide archive of structural data of biological macromolecules. This paper describes the data uniformity project that is underway to address the inconsistency in PDB data.
T N, Bhat, P, Bourne, Z, Feng, G, Gilliland, S, Jain, V, Ravichandran, B, Schneider, K, Schneider, N, Thanki, H, Weissig, J, Westbrook, H M, Berman   +11 more
openaire   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes

Data in Brief, 2016
This article presents detailed purification procedures for the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B. In addition we provide crystallization protocols for apo BRD4(1) and BRD4(1) in complex with numerous inhibitors.
Martin Hügle, Xavier Lucas, Gerhard Weitzel, Dmytro Ostrovskyi, Bernhard Breit, Stefan Gerhardt, Karin Schmidtkunz, Manfred Jung, Roland Schüle, Oliver Einsle, Stefan Günther, Daniel Wohlwend   +11 more
doaj   +1 more source

Associative Study on Government Spending, Inflation, Trade Balance, and Gross Domestic Product

Ekuilibrium: Jurnal Ilmiah Bidan Ilmu Ekonomi, 2020
Specifically, this study aims to examine the effect of macroeconomic indicators namely government spending, inflation and trade balance on PDB. The observation period from 1981-2017 is based on International Monetary Fund (IMF) documentation.
Agus Eko Sujianto, Muhammad Fajar Ulil Azmi   +1 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Origin of the dolomite in the Buqu Formation (Mid-Jurassic) in the south depression of the Qiangtang Basin, Tibet: Evidence from petrographic and geochemical constraints

Frontiers in Earth Science, 2022
The Qiangtang Mesozoic sedimentary basin is a new field of hydrocarbon exploration, in which the Buqu Formation dolostone reservoirs have attracted increasing attention in recent years.
Youli Wan, Youli Wan, Jiashan Lin, Jiashan Lin, Zhan Zhao, Zhan Zhao, Zhonglin Wang, Zhonglin Wang   +7 more
doaj   +1 more source