Results 71 to 80 of about 431 (193)

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, Volume 13, Issue 45, 13 August 2026.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Rock-Breaking Mechanism of Special-shaped PDC Cutter in Heterogeneous Granite

Shiyou jixie, 2022
In order to clarify the rock-breaking mechanism of special-shaped PDC cutter in the difficult-to-drill formations(e.g. granite), the finite element method was used to establish a mesoscopic heterogeneous granite model with different mineral components ...
Liu Hexing, Luo Yunxu, Liu Weiji, Ma Chuanhua, Wu Yanhui, Zhu Xiaohua, Liu Yaya   +6 more
doaj  

Tumor‐Infiltrating mregDCs Restrain Anti‐Tumor Immunity in Early Relapse HCC

Advanced Science, Volume 13, Issue 45, 13 August 2026.
Tumor‐infiltrating mregDCs are regulated by the TNFR2‐non‐canonical NF‐κB axis, which is mediated by TNF‐α secreted by CD161+CD8+ T cells. These mregDCs recruit CD161+CD8+ T cells via the CCL20‐CCR6 axis, forming a positive feedback loop that enhances immunosuppression, promotes early recurrence of HCC, and further confirms TNFR2 as a key therapeutic ...
Zefan Zhang, Lin Ding, Yu Zhong, Haokang Feng, Linglong Huang, Waidong Huang, Chunqing Wang, Arne Östman, Beili Wang, Jian Zhou, Jia Fan, Wei Guo, Liang Wu, Yunfan Sun   +13 more
wiley   +1 more source

Proteomic Differentiation of Colorectal Cancer From Normal Tissue via Ex Vivo E‐Biopsy: A Novel Approach to Molecular Sampling for Diagnostic Precision

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Colorectal cancer (CRC) is one of the most common malignancies worldwide. Early and accurate diagnosis remains a clinical priority, yet current biopsy techniques are invasive, spatially limited, and may not capture the molecular heterogeneity of tumors.
Gintautas Saulis, Edward Vitkin, Rita Saule, Julia Wise, Antanas Gulbinas, Žilvinas Dambrauskas, Sandra Ivanauskienė, Justas Žilinskas, Lina Poskiene, Alexander Golberg   +9 more
wiley   +1 more source

Customized Design and Application of High ROP Bit for Deep Shale Gas

Shiyou jixie
As the development scale of shale gas expands， improving the rate of penetration （ROP） of deep shale gas has become the key to improving development efficiency， and designing more targeted bit based on formation characteristics is an effective means to ...
Zhu Xiaohua, Deng Kaichuang, Liu Weiji, Li Ke, Li Yuanjun, Chen Wei, Yan Juntao   +6 more
doaj   +3 more sources

Renewable‐Based Electric Vehicle Charging and Grid Support Through Bi‐Level Optimization

Energy Storage, Volume 8, Issue 5, August 2026.
ABSTRACT This study proposes a bi‐level optimization framework for coordinated electric vehicle charging and discharging in renewable‐based distribution networks. The upper‐level problem minimizes feeder losses from the Distribution Grid Operator perspective, while the lower‐level problem minimizes charging costs for electric vehicle owners under time ...
Wei Peng, Omid Karimi Sadaghiani, Ilknur Tunc, Taner Altunok, Sahba Tabarraei   +4 more
wiley   +1 more source

Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 8, August 2026.
The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng, Shuiquan Li, Zhigang Zhang, Mengke Niu, Jing Fei, Jiaojiao Zhang, Jianwei Zhou, Kongming Wu, Ming Yi, Tianye Li   +9 more
wiley   +1 more source

Mesoscopic Damage Simulation of Sandstone during PDC-Cutter Cutting

Shiyou jixie, 2023
In the process of rock cutting,the cutting parameters of the tool have important influences on the failure mode and rock-breaking efficiency.In order to investigate the mesoscopic damage of sandstone cut by PDC cutter under different cutting parameters ...
Yang Hongyu, Deng Rong, Ye Bailiang, He Xiangjiang, Huang Anlong   +4 more
doaj  

Irradiated Liver Cancer Cell Vaccine Transfected With GM‐CSF Induces Specific and Long‐Lasting Anti‐tumour Immunity Through the Synergistic Effect of Oxidised mtDNA and GM‐CSF

Cell Proliferation, Volume 59, Issue 8, August 2026.
Song et al. developed an mGM‐CSF‐loaded, liver cancer cell‐based vaccine that potently activated dendritic cells and elicited tumour‐specific T cell responses. Mechanistically, radiation‐induced oxidative damage to mitochondrial DNA in cancer cells triggers the cGAS‐STING pathway in DCs, which synergizes with mGM‐CSF‐driven JAK2‐STAT3 signalling to ...
Zhiruo Song, Yujie Jiang, Yu Zhang, Danyi Ao, Chunjun Ye, Xiya Huang, Yingqiong Zhou, Hanle Yang, Ruolan Xia, Jiayuan Ai, Dandan Wan, Aiping Tong, Yuquan Wei, Xuemei He, Aqu Alu, Xiawei Wei   +15 more
wiley   +1 more source

Polymer‐Derived Ceramics: A Materials Platform for Advanced Energy and Environmental Applications

Journal of the American Ceramic Society, Volume 109, Issue 8, August 2026.
Polymer‐derived ceramics (PDCs) represent a unique class of materials bridging polymer chemistry and ceramic science, perfectly suited for the design of advanced materials for current technological challenges of high societal impact particularly in energy and environmental domains.
Hippolyte Dory, Chrystelle Salameh, Philippe Miele   +2 more
wiley   +1 more source