Results 51 to 60 of about 47,748 (185)

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source

AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells

Advanced Science, EarlyView.
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen, Huibo Wang   +12 more
wiley   +1 more source

Effects of Rock/Cutter Friction on PDC Bit Drilling Performance: An Experimental and Theoretical Study. [PDF]

, 1990
A new mechanistic drilling model for PDC bits was derived from the balance of forces acting at the PDC cutter. The model combined the torque and the drilling rate equations, cutter\u27s geometry and rock properties.
Kuru, Ergun
core   +1 more source

New Bit with Rolling PDC Cutter

Shiyou jixie, 2016
The new rolling PDC cutter drill bit technology could effectively address the fixed cutter eccentric wear issue,prolong durability,improve ROP,resulting in improved drilling efficiency and reduced drilling costs,which is a great step of drill bit ...
Shi Jiangang, Wu Xingyong, Dang Wenhui, Deng Ping, Liu Gang   +4 more
doaj  

Numerical modeling on drilling fluid and cutter design effect on drilling bit cutter thermal wear and breakdown

Journal of Petroleum Exploration and Production Technology, 2019
The unconventional reservoir geological complexity will reduce the drilling bit performance. The drill bit poor performance was the reduction in rate of penetration (ROP) due to bit balling and worn cutter and downhole vibrations that led to ...
Ahmad Zhafran Ayop, Ahmad Zafri Bahruddin, Belladonna Maulianda, Aruvin Prakasan, Shamammet Dovletov, Eziz Atdayev, Ahmad Majdi Abdul Rani, Khaled Abdalla Elraies, Tarek Al-arbi Ganat, Reza Barati, Sia Chee Wee   +10 more
doaj   +1 more source

Zebrafish xenograft models as a fast platform for metastasis diagnosis and cisplatin response of head and neck squamous cell carcinoma

Animal Models and Experimental Medicine, EarlyView.
A zebrafish xenograft model accurately distinguishes metastatic from non‐metastatic HNSCC and recapitulates cisplatin sensitivity/resistance patterns. Using patient‐derived tumors, it predicts individual therapeutic responses, offering a rapid, clinically applicable platform for guiding personalized treatment. Abstract Background Head and neck squamous
Lu Chen, Shu Sun, Yujia Liu, Liehao Jiang, Cuiyun Wu, Ting Liu, Yujiao Zhao, Yuwei Liu, Lu Liu, Qi Wang, Xiaowei Zheng, Ping Huang   +11 more
wiley   +1 more source

Standardization of measurement and reporting of medication adherence using the TEN‐SPIDERS tool for claims data

British Journal of Clinical Pharmacology, EarlyView.
This study provides the first open‐source tool to implement the complete TEN‐SPIDERS framework in linked datasets for the determination of the PDC for medication adherence. The TEN‐SPIDERS tool enables transparent, reproducible medication adherence research through automated reporting of all calculation parameters and flexible customization options ...
Adam C. Livori, Tzu‐Yung Kuo, Jenni Ilomäki, Monique F. Kilkenny, Stella Talic, Zanfina Ademi, J. Simon Bell, Jedidiah I. Morton, Lachlan L. Dalli   +8 more
wiley   +1 more source

Correlation between machining direction, cutter geometry and step-over distance in 3-axis milling: Application to milling by zones. [PDF]

, 2012
Computer-Aided Manufacturing (CAM) occupies an increasingly important role in engineering with all it has to offer in terms of new possibilities and improving designer/manufacturer productivity. The present study addresses machining of free-form surfaces
Senatore, Johanna, Rubio, Walter, Segonds, Stéphane, Dessein, Gilles   +3 more
core   +1 more source

A New Method for the Real-Time Monitoring of PDC Bit Cutter Wear Based on the Drilling Rate Mode

Shiyou jixie, 2020
In order to carry out real-time quantitative monitoring on the wear degree of PDC bit cutter, the drilling rate equation suitable for PDC bit was optimized.
Hao Yalong, Ge Yunhua, Wang Haige, Bi Wenxin, Huang Jiagen, Liu Haoyang   +5 more
doaj  

Real‐time lithology identification while drilling based on drill cuttings image analysis with ensemble learning

Deep Underground Science and Engineering, EarlyView.
A lithology identification while drilling method was developed, integrating an automated cuttings sampling system, a smart drilling rig, and an ensemble learning model. Underground trials achieved 97.42% accuracy in real‐time identification of cuttings lithology and composition, enhancing hazard management and supporting unmanned drilling technology in
Kun Li, Ting Ren, Ningping Yao, Jon Roberts, Haitao Song, Zhongbei Li, Xueqiu He, Liang Zhao   +7 more
wiley   +1 more source