Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy
Advanced Science, EarlyView.This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao +5 more
wiley +1 more source
A Geologic Si‐O‐C Pathway to Incorporate Carbon in Silicates
Geophysical Monograph Series, Page 47-54., 2020 This book is Open Access. A digital copy can be downloaded for free from Wiley Online Library.
Explores the behavior of carbon in minerals, melts, and fluids under extreme conditions
Carbon trapped in diamonds and carbonate-bearing rocks in subduction zones are examples of the continuing exchange of substantial carbon ...
Alexandra Navrotsky +2 more
wiley +1 more source
Advanced Science, EarlyView.Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu +11 more
wiley +1 more source
Theoretical research on the ploughing rock breaking properties of new conical PDC cutter
, 2019 The researches on the conical PDC cutter are now focused on numerical simulation, field and laboratory tests, the theoretical analysis on its mechanical properties has not been reported.
Chuanliu, WANG, Pei, JU
core +1 more source
Research on Cutting Load and Heat Generation Law of PDC Wearing Cutter
Shiyou jixie, 2021 At present, there is no further researches on the cutting load and heat generation of worn PDC cutter under different front rake angles and different wear grades. For this reason, single cutter cutting tests are used to verify the relevant performance of
Zhu Guanghui, Kuang Yuchun, Lin Wei
doaj
Numerical simulation of rock breaking by PDC bit in hot dry rocks
Natural Gas Industry B, 2019 Penetrating through hot dry rocks for geothermal resources with high geothermal gradients, high degrees of hardness and abrasivity will be extremely difficult, and a reasonable tooth distribution is a key factor to improve its rock-breaking efficiency ...
Xiaohua Zhu, Zhaowang Dan
doaj +1 more source
Advanced Science, EarlyView.A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo +10 more
wiley +1 more source
Numerical Simulation on Shale Fragmentation by a PDC Cutter Based on the Discrete Element Method
, 2023 During the guided drilling process as part of shale gas exploration and development, shale is damaged by a polycrystalline diamond compact (PDC) bit cutter. It is essential to carry out research on rock breaking by a PDC cutter.
Shengwen Qi +5 more
core +1 more source
Alexandria Engineering Journal, 2020 For the polycrystalline diamond compact (PDC) bit, the first step of rock breaking is to press the bit into the rock. However, it is very difficult to theorize the pressing process, due to the complex structure of cutting tooth, the large deformation of ...
Yijin Zeng +5 more
doaj +1 more source
Effect of Back Rake Angle and Shape of PDC Cutter On Wear Rate In Hard Formation [PDF]
, 2015 This project aimed to investigate the effect of cutter back rake angle and shape of cutter on Polycrystalline Diamond Compact (PDC) cutter wear rate in hard formation application.
Yi, Kong Yien
core