Results 21 to 30 of about 47,748 (185)

Influence of PDC Cutter Diameter on Cutting Force

Shiyou jixie, 2023
PDC bit design needs to be customized depending upon the formation lithology characteristics, and especially the diameter of PDC cutter is an important parameter in bit design optimization.A series of laboratory simulation tests were conducted to explore
Wei Jiusen, Shao Fangyuan, Tan Ziyang, Liu Wei, Gao Deli   +4 more
doaj  

Failure analysis and optimum structure design of PDC cutter

, 2017
The PDC (Polycrystalline Diamond Compact) cutter is widely prevailed in the markets of measuring and cutting tools, down-hole tools of oil and gas drilling, mining and geothermal drilling industries.
Chunyan Kong, Zhang, Derong, Kong, Chunyan, Zheng Liang, Derong Zhang, Liang, Zheng   +5 more
core   +1 more source

Research on Rock Breaking Force Prediction Model of PDC Cutter

Shiyou jixie, 2021
In order to study the influence of cutting parameters of PDC cutter on its stress, an orthogonal test of rock breaking by PDC cutter was designed; based on which, the multiple linear regression prediction model and artificial neural network prediction ...
Li Jin, Yin Zhuo, Liu Zhong, Hou Huihui
doaj  

Cutting Efficiency of a Single PDC Cutter on Hard Rock

, 2009
Polycrystalline diamond compact (PDC) bits have gained wide popularity in the petroleum industry for drilling soft and moderately firm formations. However, in hard formation applications, the PDC bit still has limitations, even though recent developments
Wise, Jack L., Hareland, Geir, Yan, W., Nygaard, Runar   +3 more
core   +1 more source

The Influence of Mixed Cutter Arrangement Parameters of PDC Bit on Rock Breaking

Shiyou jixie, 2020
To optimize the cutting structure of the mixed cutter arranged PDC bit and improve the rock breaking efficiency, an independent design test device was used to carry out the experimental research and numerical simulation on the influence of the cutter ...
Liu Zhong, Hu Wei, Yin Zhuo, Hou Huihui
doaj  

Numerical Simulation Study on Rock Breaking Characteristics of Prismatic PDC Cutter under Triaxial Stress

Shiyou jixie, 2021
The research on rock breaking mechanism of special-shaped non-planar PDC cutter is relatively scarce, and the research on domestic prismatic PDC cutter is even scarcer.
Wei Xiuyan, He Wenhao, Shi Huaizhong, Chen Zhenliang, Xiong Chao, Li Shuowen   +5 more
doaj  

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Cutting of Siliceous Dolomite by Special-Shaped PDC Cutter under Confining Pressure

Shiyou jixie
The dolomite formation is an important field for oil and gas exploration in the future. However， due to the high confining pressure environment in wellbore and the hard-to-drill characteristics of dolomite， traditional planar cutter PDC bit is prone to ...
Tian Wanqing, Liu Weiji, Qin Dehong, Liu Chenglong, Wang Haitao, Hu Hai   +5 more
doaj   +3 more sources

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Advanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng   +18 more
wiley   +1 more source