Results 161 to 170 of about 174,626,138 (254)

Hypercapnia Induces Mitochondrial Adaptations and Alters Glutamine Metabolism to Drive a Distinct Metabolic Phenotype in Monocytes

Immunology &Cell Biology, EarlyView.
Elevated CO2 (hypercapnia) is a feature of serious lung diseases, for example COPD and contributes to poor patient prognosis through modulation of immune cell function. Here we employ state‐of‐the art metabolomic and isotope tracing approaches to reveal CO2‐dependent mitochondrial alterations linked to suppressed ATP, proline and glutamate levels in ...
Ben Reddan, David E. Phelan, Xiaofei Yin, Lorraine Brennan, Martina Wallace, Eoin P. Cummins   +5 more
wiley   +1 more source

Delay Differential Equation Approach to Oligomerization Reveals the Delay Dynamics Underlying Oscillations in Mitochondrial Fission. [PDF]

Bull Math Biol
Fynaardt K, Leinheiser AK, Mitchell CC, Grueter CE.   +3 more
europepmc   +1 more source

The Evolution of Interest‐Rate Models: From the Yield Curve to the Swaption Cube

Journal of Economic Surveys, EarlyView.
ABSTRACT Interest‐rate modelling is often taught as a catalogue of competing stochastic equations, obscuring why models were created and why modern sell‐side desks use several simultaneously. This survey reorganises the field around five layers of a pricing architecture: curve construction; arbitrage‐free dynamics; volatility‐smile representation ...
Xuan Feng, Salman Huseynov, Diomides Mavroyiannis   +2 more
wiley   +1 more source

PDE and agent based simulation approaches to Ischemic Dermal Wound Closure. [PDF]

PLoS One
Lazebnik T, Friedman A.
europepmc   +1 more source

Perceptions of Medications and Supplements by U.S. Dog‐Interested Members of the Public and Final‐Year Veterinary Students

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Veterinary graduates must be prepared to educate clients about medications and supplements. We surveyed 1955 Dog Aging Project newsletter recipients and 40 final‐year veterinary students at Texas A&M College of Veterinary Medicine and Biomedical Sciences on their perceptions about medications and supplements. Respondents indicated whether each
Sidonie T. Gallinger, Johanna C. Heseltine, Kate Illing, Virginia R. Fajt, Dog Aging Project Consortium, Joshua M. Akey, Brooke Benton, Elhanan Borenstein, Marta G. Castelhano, Amanda E. Coleman, Kate E. Creevy, Kyle Crowder, Matthew D. Dunbar, Virginia R. Fajt, Annette L. Fitzpatrick, Unity Jeffery, Erica C. Jonlin, Matt Kaeberlein, Elinor K. Karlsson, Kathleen F. Kerr, Jonathan M. Levine, Jing Ma, Robyn L. McClelland, Daniel E. L. Promislow, Audrey Ruple, Stephen M. Schwartz, Sandi Shrager, Noah Snyder‐Mackler, M. Katherine Tolbert, Silvan R. Urfer, Benjamin S. Wilfond, Kate E. Creevy   +31 more
wiley   +1 more source

Two novel phosphodiesterases (PDEs) found from woody plant jujube exhibit diverse biological functions via regulating cAMP, cGMP and hormones. [PDF]

BMC Plant Biol
Zhao X, Wang D, Deng X, Mai J, Liu Z, Liu M.   +5 more
europepmc   +1 more source

Measure‐valued processes for energy markets

Mathematical Finance, Volume 35, Issue 2, Page 520-566, April 2025.
Abstract We introduce a framework that allows to employ (non‐negative) measure‐valued processes for energy market modeling, in particular for electricity and gas futures. Interpreting the process' spatial structure as time to maturity, we show how the Heath–Jarrow–Morton approach can be translated to this framework, thus guaranteeing arbitrage free ...
Christa Cuchiero, Luca Di Persio, Francesco Guida, Sara Svaluto‐Ferro   +3 more
wiley   +1 more source

A fission yeast-based platform for nematode PDE inhibitor discovery. [PDF]

Cell Signal
Bibeau S, Chen N, Sutoris H, Ly J, Eberhard J, Hubbell SM, Banda E, Povh E, Anindya CS, Berwanger MR, Sinise SE, Zhang X, Morken JP, Galande KK, Cote RH, Dranchak PK, Inglese J, Hoffman CS.   +17 more
europepmc   +1 more source

Reinforcement Learning for Jump‐Diffusions, With Financial Applications

Mathematical Finance, EarlyView.
ABSTRACT We study continuous‐time reinforcement learning (RL) for stochastic control in which system dynamics are governed by jump‐diffusion processes. We formulate an entropy‐regularized exploratory control problem with stochastic policies to capture the exploration–exploitation balance essential for RL.
Xuefeng Gao, Lingfei Li, Xun Yu Zhou
wiley   +1 more source

Exposure to Toxicologically Relevant Inorganic Elements and Nicotine Content Variability in Electronic Nicotine Delivery System (ENDS) E-Liquids. [PDF]

Chem Res Toxicol
Catarino LM, Iozzi GM, Silva CB, Neto SAV, Reis GA, Jacob SC, Dos Santos LMG.   +6 more
europepmc   +1 more source