Results 111 to 120 of about 222,931 (262)

Extracellular Vesicles of Patients on Peritoneal Dialysis Inhibit the TGF-β- and PDGF-B-Mediated Fibrotic Processes

Cells
Among patients on peritoneal dialysis (PD), 50–80% will develop peritoneal fibrosis, and 0.5–4.4% will develop life-threatening encapsulating peritoneal sclerosis (EPS).
Beáta Szebeni, Apor Veres-Székely, Domonkos Pap, Péter Bokrossy, Zoltán Varga, Anikó Gaál, Judith Mihály, Éva Pállinger, István M. Takács, Csenge Pajtók, Mária Bernáth, György S. Reusz, Attila J. Szabó, Ádám Vannay   +13 more
doaj   +1 more source

PDE-DKL: PDE-constrained deep kernel learning in high dimensionality

Many physics-informed machine learning methods for PDE-based problems rely on Gaussian processes (GPs) or neural networks (NNs). However, both face limitations when data are scarce and the dimensionality is high. Although GPs are known for their robust uncertainty quantification in low-dimensional settings, their computational complexity becomes ...
Yan, Weihao, Brune, Christoph, Guo, Mengwu   +2 more
openaire   +3 more sources

LE-PDE++: Mamba for accelerating PDEs Simulations

Partial Differential Equations are foundational in modeling science and natural systems such as fluid dynamics and weather forecasting. The Latent Evolution of PDEs method is designed to address the computational intensity of classical and deep learning-based PDE solvers by proposing a scalable and efficient alternative.
Liang, Aoming, Mu, Zhaoyang, liu, Qi, Li, Ruipeng, Ge, Mingming, Fan, Dixia   +5 more
openaire   +2 more sources

Clinical Efficacy and Safety of Topical Roflumilast in Psoriasis: An Updated Systematic Review and Meta‐Analysis of Randomized Controlled Trials

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Traditional first‐line topical treatments for plaque psoriasis, particularly corticosteroids and vitamin D analogs, frequently have only limited efficacy for long‐term use, and present difficulties with safety and adherence. Objectives In this systematic review and meta‐analysis of randomized controlled trials (RCTs), we assessed ...
Aimal A. Khattak, Ahmed Javed, Ummi Aiman Rahman, Rumaisa Riaz, Zeeshan Imtiaz, Hassan A. Mirza, Farman U. Khan, Muhid Khattak, Fatima Javid, Abdul Moiz Khan, Adeline L. Roy, Bibek Shrestha   +11 more
wiley   +1 more source

New Biologic and Small Molecule Therapies for Hidradenitis Suppurativa

JEADV Clinical Practice, EarlyView.
ABSTRACT Hidradenitis suppurativa (HS) is an inflammatory skin disease that has historically been underdiagnosed and, until recently, under‐researched. Furthermore, the pathophysiology of HS is complex, and not fully understood. Just three biologic medications—adalimumab (anti‐TNF‐α), secukinumab (anti‐IL17A) and bimekizumab (anti‐IL17A/F) are licensed
Emily Pender, Rosalind Hughes, Brian Kirby   +2 more
wiley   +1 more source

Do Medication Beliefs Influence Adherence to Topical Therapies in Patients With Atopic Dermatitis?

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Atopic dermatitis (AD) is a chronic inflammatory skin condition affecting 10–20% of the global population and is characterized by red, itchy, and dry skin. While consistent medication adherence is necessary for adequate management of AD, patients' adherence to topical therapies can decline by 70% within initial days of treatment ...
Vivien Wen Ting Tai, Luke Jun Jie Oh, Yik Weng Yew, Benny Kaihui Li   +3 more
wiley   +1 more source

Numerical PDE solvers outperform neural PDE solvers

We present DeepFDM, a differentiable finite-difference framework for learning spatially varying coefficients in time-dependent partial differential equations (PDEs). By embedding a classical forward-Euler discretization into a convolutional architecture, DeepFDM enforces stability and first-order convergence via CFL-compliant coefficient ...
Chatain, Patrick, Rizvi-Martel, Michael, Rabusseau, Guillaume, Oberman, Adam   +3 more
openaire   +2 more sources

Unveiling New Perspectives on the Hirota–Maccari System With Multiplicative White Noise

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT In this study, we delve into the stochastic Hirota–Maccari system, which is subjected to multiplicative noise according to the Itô sense. The stochastic Hirota–Maccari system is significant for its ability to accurately model how stochastic affects nonlinear wave propagation, providing valuable insights into complex systems like fluid dynamics
Mohamed E. M. Alngar, Khaled A. Gepreel, Reham M. A. Shohib, Yakup Yildirim   +3 more
wiley   +1 more source

The Combined Effects of Variable Viscosity and Thermal Conductivity of An Unsteady Casson Fluid Flow Along a Vertical Porous Channel With Convective Cooling Walls, Using the Bivariate Spectral Local Linearization Method

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT This study examines the combined impact of different thermal conductivity and viscosity on unsteady non‐Newtonian Casson fluid flow of incompressible, electrical conductivity in a porous vertical channel with convective cooling walls, uniform magnetic field, and constant pressure gradient.
A. S. Adeyemo, Precious Sibanda, S. P. Goqo   +2 more
wiley   +1 more source

Interaction of Dirac δ$$ \delta $$‐Waves in the Inviscid Levine and Sleeman Chemotaxis Model

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT This article investigates interactions of δ$$ \delta $$‐shock waves in the inviscid Levine and Sleeman chemotaxis model ut−λ(uv)x=0$$ {u}_t-\lambda {(uv)}_x=0 $$, vt−ux=0$$ {v}_t-{u}_x=0 $$. The analysis employs a distributional product and a solution concept that extends the classical solution concept.
Adelino Paiva
wiley   +1 more source