Results 111 to 120 of about 116,861 (304)

Preparation and Characterization of 5′-Phosphodiesterase from Barley Malt Rootlets

Natural Product Communications, 2010
Two 5′- phosphodiesterases (5′-PDE-a and 5′-PDE-b) were isolated from barley malt rootlets, and further purified by gel filtration on Sephadex G-25 and Sephadex G-75.
Jie Hua, Ke-long Huang
doaj   +1 more source

The effect of selective phosphodiesterase inhibitors, alone and in combination, on a murine model of allergic asthma

Respiratory Research, 2004
Background The anti-inflammatory effects of the selective phosphodiesterase (PDE) inhibitors cilostazol (PDE 3), RO 20-1724 (PDE 4) and sildenafil (PDE 5) were examined in a murine model of allergic asthma.
Galbraith Deirdre, Nagasawa Michiaki, Mackenzie Alison, Dick Colin AJ, Clayton Robert A, Hastings Stuart F, MacKenzie Simon J   +6 more
doaj   +1 more source

Research progress and current status of dynamic wave propagation characteristics in rock mass: A review

Deep Underground Science and Engineering, EarlyView.
This review elucidates the velocity–dispersion–attenuation coupling mechanisms of wave propagation in rock masses, compares six representative models, and reveals how pressure, temperature, mineral composition, and anisotropy jointly control dynamic responses in complex geological media.
Jiajun Shu, Tao Li, Ruiqi Yuan, Yue Li, Bingni Wu, Bo Liu, Zhengding Deng, Galindo Rubén, Fausto Molina‐Gómez   +8 more
wiley   +1 more source

Numerical PDE solvers outperform neural PDE solvers

CoRR
We present DeepFDM, a differentiable finite-difference framework for learning spatially varying coefficients in time-dependent partial differential equations (PDEs). By embedding a classical forward-Euler discretization into a convolutional architecture, DeepFDM enforces stability and first-order convergence via CFL-compliant coefficient ...
Patrick Chatain, Michael Rizvi-Martel, Guillaume Rabusseau, Adam Oberman   +3 more
openaire   +2 more sources

Multi‐factor coupling effects in hydraulic fracturing of laminated shale: Experimental insights and physics‐informed neural network‐driven optimization

Deep Underground Science and Engineering, EarlyView.
This study establishes a multi‐factor coupling framework for predicting breakdown pressure in laminated shale by integrating experimental hydraulic fracturing tests, physics‐informed neural networks (PINNs), and Sobol sensitivity analysis. It reveals how differential stress, the bedding dip angle, and the injection rate interact to influence fracture ...
Tao Wang, Guoyao Xu, Liyuan Liu, Yao Zhang, Sitao Zhu, Hongyang Chu, Kaikai Zhao   +6 more
wiley   +1 more source

Myocardial inflammation is associated with impaired mitochondrial oxidative capacity in ischaemic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1246-1255, April 2025.
Abstract Aims Myocardial inflammation and impaired mitochondrial oxidative capacity are hallmarks of heart failure (HF) pathophysiology. The extent of myocardial inflammation in patients suffering from ischaemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM) and its association with mitochondrial energy metabolism are unknown.
Julius Borger, Elric Zweck, Constanze Moos, Patrick Horn, Fabian Voß, Heinz‐Peter Schultheiss, Jacob Eifer Møller, Udo Boeken, Hug Aubin, Artur Lichtenberg, Malte Kelm, Michael Roden, Amin Polzin, Ralf Westenfeld, Julia Szendroedi, Daniel Scheiber   +15 more
wiley   +1 more source

The role of phosphodiesterase type-5 inhibitors in treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia

Urology Research and Practice, 2019
Phosphodiesterase type-5 (PDE-5) inhibitors are approved as the first line of therapy for the treatment of erectile dysfunction. However, different studies have been performed to study the use of these agents in other areas of urology.
Mehmet UMUL, Tekin Ahmet SEREL
doaj   +1 more source

PDE-PRESERVING PROPERTIES [PDF]

Journal of the Korean Mathematical Society, 2005
A continuous linear operator \(T\) on the space of entire functions in \(d\) variables is called PDE-preserving for a given set \(\mathbb{P}\subseteq\mathbb{C}[\xi_1,\ldots,\xi_d]\) of polynomials if \(T\ker P(D)\subseteq P(D)\) for all \(P\in\mathbb P\), where \(P(D)\) is the differential operator obtained by replacing each variable \(\xi_j\) by ...
openaire   +1 more source

Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial

ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.
• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad, Jeanne du Fay de Lavallaz, Michael J. Zhang, Thanat Chaikijurajai, Bo Ye, Prabhjot S. Nijjar, Julie A. Lahiri, Cindy M. Martin, Tamas Alexy, Markus Meyer   +9 more
wiley   +1 more source

An investigation into the correlation between intraperitoneal teicoplanin concentrations and treatment outcomes in peritoneal dialysis-associated peritonitis

Frontiers in Pharmacology
Peritoneal dialysis-associated peritonitis (PDAP) is a frequent complication of peritoneal dialysis. The guidelines from the International Society for Peritoneal Dialysis (ISPD) suggest administering teicoplanin through the peritoneal route to treat PDAP,
Lulu Wang, Lulu Wang, Jiangqing Fan, Xuejie Chen, Wenpu Lei, Chunming Jiang, Hang Liu, Yun Yang, Jizhong Shen   +8 more
doaj   +1 more source