Results 61 to 70 of about 33,386 (268)

Postimplant Phosphodiesterase Type 5 Inhibitors Use Is Associated With Lower Rates of Thrombotic Events After Left Ventricular Assist Device Implantation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Left ventricular assist device (LVAD) thrombosis is clinically devastating and impacts the cost effectiveness of LVAD therapy for advanced heart failure.
Andrew Xanthopoulos, Konstantinos Tryposkiadis, Filippos Triposkiadis, Kiyotaka Fukamachi, Edward G. Soltesz, James B. Young, Kathy Wolski, Eugene H. Blackstone, Randall C. Starling   +8 more
doaj   +1 more source

Disentangling Aleatoric and Epistemic Uncertainty in Physics‐Informed Neural Networks: Application to Insulation Material Degradation Prognostics

Advanced Intelligent Systems, EarlyView.
Physics‐Informed Neural Networks (PINNs) provide a framework for integrating physical laws with data. However, their application to Prognostics and Health Management (PHM) remains constrained by the limited uncertainty quantification (UQ) capabilities.
Ibai Ramirez, Jokin Alcibar, Joel Pino, Mikel Sanz, Jose I. Aizpurua   +4 more
wiley   +1 more source

Phosphodiesterase 10A as a Therapeutic Target in Neuropsychopharmacology: A Review

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. Phosphodiesterases (PDEs) are enzymes that regulate intracellular signalling by catalysing the hydrolysis of cyclic nucleotides. The commercial success of selective PDE5 inhibitors for erectile dysfunction and PDE4 inhibitors for ...
A. R. Dorotenko, I. M. Sukhanov, G. V. Iskarevskii, A. S. Ulitina, A. A. Savchenko, M. А. Tur   +5 more
doaj   +1 more source

Radiation‐Absorptive Heat Transport in Buoyancy‐Driven MHD Nanofluids Flow With Cross‐Diffusion and Chemical Interaction Effects Over a Vertical Moving Plate

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT This article investigates the Soret–Dufour cross‐diffusion effects on radiation‐absorptive unsteady free‐convection of magnetized nanofluids (TiO2–water$$ {\mathrm{TiO}}_2\hbox{--} \mathrm{water} $$ and Cu–water$$ \mathrm{Cu}\hbox{--} \mathrm{water} $$) flow over a vertical moving permeable plate.
B. Prabhakar Reddy, Jumanne Mng'ang'a, P. V. Kanaka Rao   +2 more
wiley   +1 more source

Geometry of PDEs. I: Integral bordism groups in PDEs

Journal of Mathematical Analysis and Applications, 2006
Global solutions of formally integrable and completely integrable systems of partial differential equations are characterized by means of integral bordism groups. Unfortunately, a thorough acquintance with the author's articles, namely with \textit{A. Prástaro} [Acta Appl. Math. 51, 243--302 (1998; Zbl 0924.58103) and Acta Appl. Math.
openaire   +3 more sources

Development of a population pharmacokinetic model using combined paediatric and adult data for four pulmonary arterial hypertension drugs

British Journal of Clinical Pharmacology, EarlyView.
Aims Pulmonary arterial hypertension (PAH) is a syndrome characterized by elevated pulmonary artery pressure. We developed a population pharmacokinetic (PPK) model using combined plasma drug concentration data from Japanese paediatric (<15 years) and adult (≥15 years) patients with PAH to investigate the pharmacokinetic characteristics of PAH ...
Motoyasu Miura, Shimako Tanaka, Ririka Aihara, Shun Yamamoto, Yasumi Nakashima, Yasuharu Kashiwagura, Akio Hakamata, Sachiko Miyakawa, Mariko Tatsuguchi, Keiichi Odagiri, Noriyuki Namiki, Naoki Inui, Hiroshi Watanabe, Shinya Uchida   +13 more
wiley   +1 more source

Numerical and Experimental Assessment of Oxygen Distribution in a Perfusion Bioreactor to Mimic the Osteochondral Niche

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Oxygen supply is a critical parameter in 3D cell cultivation using bioreactors. Since bioreactor designs often prioritise practical constraints, understanding the oxygen supply dynamics of the media is crucial for achieving either uniform or spatially controlled oxygen delivery.
Franziska Alt, Eric Langner, Hans‐Peter Wiesmann, Thomas Wallmersperger, Benjamin Kruppke   +4 more
wiley   +1 more source

Image Denoise by Fourth-Order PDE Based on the Changes of Laplacian

Journal of Algorithms & Computational Technology, 2008
Fourth-order partial differential equation (PDE) proposed by You and Kaveh (You-Kaveh fourth-order PDE), which replaces the gradient operator in classical second-order nonlinear diffusion methods with a Laplacian operator, is able to avoid blocky effects
Lan Lŭ, Meiqing Wang, Choi-Hong Laib
doaj   +1 more source

Optimization of 3D‐Printed Structured Packings—Current State and Future Developments

Chemie Ingenieur Technik, EarlyView.
This paper gives an overview about structured packing development for distillation, surveying heuristic development cycles, computational fluid dynamics simulations, and additive manufacturing techniques. The emerging application of shape optimization to improve packings is emphasized, and its benefits, impact, and limitations are discussed.
Dennis Stucke, Sebastian Blauth, Christian Leithäuser, Thomas Grützner   +3 more
wiley   +1 more source

Implicit solutions of PDEs [PDF]

Journal of Physics A: Mathematical and General, 2004
11 pages ...
openaire   +2 more sources