PDE10A as a novel diagnostic and therapeutic target in cancer: insights and challenges [PDF]
Frontiers in OncologyPhosphodiesterase 10A (PDE10A) is a dual-substrate enzyme that hydrolyzes both cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), playing a critical role in regulating intracellular signaling pathways. While its function has
Sahar Ghoflchi +5 more
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Inhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome [PDF]
Advanced ScienceFOXP1 syndrome caused by FOXP1 haploinsufficiency is characterized by intellectual disability, speech, and language impairment, autistic features, and neuropsychiatric abnormalities such as anxiety and hyperactivity.
Henning Fröhlich +8 more
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Phosphodiesterase 10A (PDE10A): Regulator of Dopamine Agonist-Induced Gene Expression in the Striatum [PDF]
Cells, 2022 Dopamine and other neurotransmitters have the potential to induce neuroplasticity in the striatum via gene regulation. Dopamine receptor-mediated gene regulation relies on second messenger cascades that involve cyclic nucleotides to relay signaling from ...
Ryan Bonate +6 more
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Magnetic resonance imaging detects white adipose tissue beiging in mice following PDE10A inhibitor treatment [PDF]
Journal of Lipid Research, 2023 Weight gain is a common harmful side effect of atypical antipsychotics used for schizophrenia treatment. Conversely, treatment with the novel phosphodiesterase-10A (PDE10A) inhibitor MK-8189 in clinical trials led to significant weight reduction ...
Michal R. Tomaszewski +6 more
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Differential changes in amygdala and frontal cortex Pde10a expression during acute and protracted withdrawal [PDF]
Frontiers in Integrative Neuroscience, 2014 Alcohol use disorders are persistent problems with high recidivism rates despite repeated efforts to quit drinking. Neuroadaptations that result from alcohol exposure and that persist during periods of abstinence represent putative molecular ...
Marian L Logrip, Eric P Zorrilla
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Structure‐based identification of dual ligands at the A2AR and PDE10A with anti‐proliferative effects in lung cancer cell‐lines [PDF]
Journal of Cheminformatics, 2021 Enhanced/prolonged cAMP signalling has been suggested as a suppressor of cancer proliferation. Interestingly, two key modulators that elevate cAMP, the A2A receptor (A2AR) and phosphodiesterase 10A (PDE10A), are differentially co-expressed in various ...
Leen Kalash +7 more
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Inhibition of CXCR2 enhances CNS remyelination via modulating PDE10A/cAMP signaling pathway
Neurobiology of Disease, 2023 CXC chemokine receptor 2 (CXCR2) plays an important role in demyelinating diseases, but the detailed mechanisms were not yet clarified. In the present study, we mainly investigated the critical function and the potential molecular mechanisms of CXCR2 on ...
Cheng Ju +13 more
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Inhibition of PDE10A in a New Rat Model of Severe Dopamine Depletion Suggests New Approach to Non-Dopamine Parkinson’s Disease Therapy [PDF]
Biomolecules, 2022 Parkinson’s disease is the second most common neurodegenerative pathology. Due to the limitations of existing therapeutic approaches, novel anti-parkinsonian medicines with non-dopamine mechanisms of action are clearly needed.
Ilya Sukhanov +8 more
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Neurobiology of Disease, 2011 Loss of dopamine neurons in experimental parkinsonism results in altered cyclic nucleotide cAMP and cGMP levels throughout the basal ganglia. Our objective was to examine whether expression of phosphodiesterase 10A (PDE10A), an isozyme presenting a ...
M. Giorgi +8 more
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Alterations of striatal phosphodiesterase 10 A and their association with recurrence rate in bipolar I disorder [PDF]
Translational PsychiatryPhosphodiesterase 10 A (PDE10A), a pivotal element of the second messenger signaling downstream of the dopamine receptor stimulation, is conceived to be crucially involved in the mood instability of bipolar I disorder (BD-I) as a primary causal factor or
Yasunori Sano +19 more
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