PDE10A mutations help to unwrap the neurobiology of hyperkinetic disorders [PDF]
, 2019 The dual-specific cAMP/cGMP phosphodiesterase PDE10A is exclusively localised to regions of the brain and specific cell types that control crucial brain circuits and behaviours. The downside to this expression pattern is that PDE10A is also positioned to
Baillie, George S. +3 more
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Maternal Pre-Pregnancy Obesity Is Associated with Altered Placental Transcriptome [PDF]
, 2018 Maternal obesity has a major impact on pregnancy outcomes. There is growing evidence that maternal obesity has a negative influence on placental development and function, thereby adversely influencing offspring programming and health outcomes.
Altmäe, Signe +11 more
core +1 more source
MODL-41. LOSS OF DISTAL CHROMOSOME 6Q AND ASSOCIATED PDE10A INDUCES AN AGGRESSIVE GLIOMA PHENOTYPE BY FACILITATING PRONEURAL TO MESENCHYMAL TRANSITION [PDF]
, 2023 Nicholas Nuechterlein +19 more
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Expression analysis of novel striatal-enriched genes in Huntington disease [PDF]
, 2017 Selective degeneration of striatal neurons is a pathologic hallmark of Huntington disease (HD). The exact mechanism(s) behind this specific neurodegeneration is still unknown.
Becanovic, Kristina +5 more
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Antidepressant treatment response is modulated by genetic and environmental factors and their interactions [PDF]
, 2014 Although there is a wide variety of antidepressants with different mechanisms of action available, the efficacy of treatment is not satisfactory. Genetic factors are presumed to play a role in differences in medication response; however, available ...
Bagdy György +6 more
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A loss-of-function homozygous mutation in DDX59 implicates a conserved DEAD-box RNA helicase in nervous system development and function. [PDF]
, 2017 We report on a homozygous frameshift deletion in DDX59 (c.185del: p.Phe62fs*13) in a family presenting with orofaciodigital syndrome phenotype associated with a broad neurological involvement characterized by microcephaly, intellectual disability ...
Ashokkumar, B +17 more
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Neurobiology of Disease, 2009 Decreased activity of cAMP responsive element-binding protein (CREB) is thought to contribute to the death of striatal medium spiny neurons in Huntington's disease (HD).
Carmela Giampà +7 more
doaj +1 more source
A Randomized Multiple Dose Pharmacokinetic Study of a Novel PDE10A Inhibitor TAK-063 in Subjects with Stable Schizophrenia and Japanese Subjects and Modeling of Exposure Relationships to Adverse Events [PDF]
, 2017 Paul Goldsmith +7 more
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