Results 101 to 110 of about 4,657 (257)

Gene expression within the extended amygdala of 5 pairs of rat lines selectively bred for high or low ethanol consumption [PDF]

, 2013
The objectives of this study were to determine innate differences in gene expression in 2 regions of the extended amygdala between 5 different pairs of lines of male rats selectively bred for high or low ethanol consumption: a) alcohol-preferring (P) vs.
Bell, Richard L., Colombo, Giancarlo, Ding, Zheng-Ming, Edenberg, Howard J., Hyytia, Petri, Kimpel, Mark W., Liang, Tiebing, Lumeng, Lawrence, McBride, William J., McClintick, Jeanette N.   +9 more
core   +1 more source

Phosphodiesterase 3 inhibitors boost bone outgrowth

British Journal of Pharmacology, Volume 182, Issue 18, Page 4327-4342, September 2025.
Background and Purpose C‐type natriuretic peptide (CNP) stimulates skeletal growth by acting on the growth plates of long bones, and a CNP variant is clinically used for achondroplasia treatment. We previously reported that CNP stimulates the autonomic Ca2+ influx mediated by TRPM7 channels in growth plate chondrocytes to facilitate extracellular ...
Takaaki Kawabe, Atsuhiko Ichimura, Tomoki Yasue, Jianhong Li, Haruki Ishikawa, Ga Eun Kim, Hiroki Nagatomo, Naoto Minamino, Yohei Ueda, Hiromu Ito, Miyuki Nishi, Hiroshi Takeshima   +11 more
wiley   +1 more source

Effects of subchronic phencyclidine on behaviour of female rats on the elevated plus maze and open field [PDF]

, 2009
YesFemale hooded-Lister rats received either sub-chronic phencyclidine (PCP) (2 mg/kg, n=20) or vehicle (1 ml/kg, n=20) i.p. twice daily for seven days, followed by a seven-day washout period. Rats were challenged with acute PCP or vehicle and tested for
Abekawa, T., JC Neill, ML Woolley, SL McLean   +3 more
core   +1 more source

Genetic Diversity and Expanded Phenotypes in Dystonia: Insights From Large‐Scale Exome Sequencing

Annals of Clinical and Translational Neurology, Volume 12, Issue 8, Page 1648-1659, August 2025.
ABSTRACT Objective Dystonia is one of the most prevalent movement disorders, characterized by significant clinical and etiological heterogeneity. Despite considerable heritability (~25%), the etiology in most patients remains elusive. Moreover, understanding correlations between clinical manifestations and genetic variants has become increasingly ...
Mirja Thomsen, Fabian Ott, Sebastian Loens, Gamze Kilic‐Berkmen, Ai Huey Tan, Shen‐Yang Lim, Ebba Lohmann, Kaja M. Schröder, Lea Ipsen, Lena A. Nothacker, Linn Welzel, Alexandra S. Rudnik, Frauke Hinrichs, Thorsten Odorfer, Kirsten E. Zeuner, Friederike Schumann, Andrea A. Kühn, Simone Zittel, Marius Moeller, Robert Pfister, Christoph Kamm, Anthony E. Lang, Yi Wen Tay, Ana Luísa de Almeida Marcelino, Marie Vidailhet, Emmanuel Roze, Joel S. Perlmutter, Jeanne S. Feuerstein, Victor S. C. Fung, Florence Chang, Richard L. Barbano, Steven Bellows, Aparna A. Wagle Shukla, Alberto J. Espay, Mark S. LeDoux, Brian D. Berman, Stephen Reich, Andres Deik, Andre Franke, Michael Wittig, Sören Franzenburg, Jens Volkmann, Norbert Brüggemann, H. A. Jinnah, Tobias Bäumer, Christine Klein, Hauke Busch, Katja Lohmann   +47 more
wiley   +1 more source

GNAO1 encephalopathy: broadening the phenotype and evaluating treatment and outcome [PDF]

, 2017
OBJECTIVE: To describe better the motor phenotype, molecular genetic features, and clinical course of GNAO1-related disease. METHODS: We reviewed clinical information, video recordings, and neuroimaging of a newly identified cohort of 7 patients ...
Bianchini, C, Carss, Kj, Dale, Rc, Danti, FEDERICA RACHELE, Galosi, Serena, Guerrini, R. 1., Kurian, Ma, Leuzzi, Vincenzo, Mahant, N, Mcshane, T, Mctague, A, Mohammad, Ss, Montomoli, M, Ng, J, Parrini, E, Raymond, Fl, Romani, M, Samanta, R, Shah, U, Vadlamani, G, Valente, Em   +20 more
core   +3 more sources

PDE10A antibodies in autoimmune encephalitis

Neurology, 2019
Although paraneoplastic neurologic syndromes have been known for over half a century, developments during the last decade have reshaped the field of autoimmune neurology. The discovery of over 15 new antibodies has expanded the clinical phenotypes associated with neurologic paraneoplastic diseases, increased therapeutic opportunities, and improved ...
Titulaer, MJ, Irani, SR, Lassmann, H
openaire   +4 more sources

Combination of the phosphodiesterase 10A inhibitor, MR1916 with risperidone shows additive antipsychotic‐like effects without affecting cognitive enhancement and cataleptic effects in rats

Neuropsychopharmacology Reports, 2020
Aim Phosphodiesterase 10A (PDE10A) inhibitors not only have antipsychotic‐like effects but also cause cognitive enhancement without affecting extrapyramidal side effects in rodents, suggesting that PDE10A may be a novel approach for the treatment of ...
Keita Arakawa, Shunsuke Maehara
doaj   +1 more source

A Comprehensive Multiomics Signature of Doxorubicin‐Induced Cellular Senescence in the Postmenopausal Human Ovary

Aging Cell, Volume 24, Issue 8, August 2025.
Explants of human postmenopausal ovarian cortex and medulla were treated with doxorubicin for 24 h followed by culture for up to 10 days in doxorubicin‐free medium. Single nuclei sequencing and proteomics revealed an unbiased signature of ovarian senescence driven by epithelial cells in the cortex and stromal cells in the cortex and medulla ...
Pooja Raj Devrukhkar, Mark A. Watson, Bikem Soygur, Fei Wu, Joanna Bons, Hannah Anvari, Tomiris Atazhanova, Nicolas Martin, Tommy Tran, Kevin Schneider, Jacob P. Rose, Daniel Winer, Elisheva Shanes, Mary Ellen G. Pavone, Judith Campisi, David Furman, Simon Melov, Birgit Schilling, Francesca E. Duncan   +18 more
wiley   +1 more source

Phosphodiesterase 10A as a Therapeutic Target in Neuropsychopharmacology: A Review

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. Phosphodiesterases (PDEs) are enzymes that regulate intracellular signalling by catalysing the hydrolysis of cyclic nucleotides. The commercial success of selective PDE5 inhibitors for erectile dysfunction and PDE4 inhibitors for ...
A. R. Dorotenko, I. M. Sukhanov, G. V. Iskarevskii, A. S. Ulitina, A. A. Savchenko, M. А. Tur   +5 more
doaj   +1 more source

Levodopa-induced dyskinesia in Parkinson disease: Current and Evolving Concepts. [PDF]

, 2018
Levodopa‐induced dyskinesia is a common complication in Parkinson disease. Pathogenic mechanisms include phasic stimulation of dopamine receptors, nonphysiological levodopa‐to‐dopamine conversion in serotonergic neurons, hyperactivity of corticostriatal ...
Ahlskog, Ahmed, Alcacer, Antonini, Barnum, Bastide, Bez, Bezard, Bezard, Bordia, Calabresi, Calabresi, Carlsson, Carta, Cerasa, Cerasa, Cerasa, Cerasa, Cilia, Durif, Durif, Elia, Espay, Espay, Fahn, Fahn, Fasano, Feyder, Fieblinger, Fiorentini, Fox, Fox, Fox, Freitas, Fuente-Fernandez, Garcia, Gardoni, Gerlach, Goetz, Goetz, Grandas, Gray, Grondin, Herz, Herz, Herz, Huang, Hung, Huot, Iderberg, Jones, Katzenschlager, Kimber, Kishore, Kleiner-Fisman, Kosillo, Krack, Laere, Lau, Lee, Lee, Lim, Litim, Mansouri, Mellone, Meloni, Merola, Morgante, Morgese, Mura, Nadjar, Niccolini, Nicoletti, Nutt, Olanow, Olanow, Pahwa, Parkinson Study Group, Pavon, Picconi, Politis, Porras, Potts, Prescott, Rocha, Rosa, Rosa, Roussakis, Ruzicka, Samadi, Santini, Shen, Sierra, Smith, Stanic, Stathis, Stelt, Suarez, Svenningsson, Swann, Tanaka, Thiele, Tison, Trenkwalder, Verhagen Metman, Whone, Wichmann, Wood, Yamamura   +108 more
core   +1 more source